Abstract: Techniques for automatically switching between chatbot skills in the same domain. In one particular aspect, a method is provided that includes receiving an utterance from a user within a chatbot session, where a current skill context is a first skill and a current group context is a first group, inputting the utterance into a candidate skills model for the first group, obtaining, using the candidate skills model, a ranking of skills within the first group, determining, based on the ranking of skills, a second skill is a highest ranked skill, changing the current skill context of the chatbot session to the second skill, inputting the utterance into a candidate flows model for the second skill, obtaining, using the candidate flows model, a ranking of intents within the second skill that match the utterance, and determining, based on the ranking of intents, an intent that is a highest ranked intent.

Abstract: The blood-brain barrier (BBB) excludes most drugs and poses a significant challenge to treat brain diseases. Current methods for BBB opening yield modest outcomes in clinical applications due to safety and toxicity. This disclosure relates to methods of optically opening the BBB by laser excitation of tight-junction targeted nanoparticles to induce BBB transient opening. The excitation of plasmonic nanoparticles produces localized effects such as nanoscale heating and photomechanical force leading to BBB transiently opening to allow macromolecules across it. The safe and predictable platform for brain drug delivery will improve therapies for brain disease such as cancers, infections and neurologic disorders.

Abstract: A system includes a solids combining system with a solids mixing section having a mixing chamber and a plurality of solids inlets configured to supply one or more solids into the mixing chamber. The system also includes a solids breakup section having a plurality of fluid inlets configured to supply one or more fluids into the mixing chamber and a solids flow control section having a converging-diverging passage downstream of the mixing chamber.

Abstract: A system includes a gasification feed injector that includes a tip portion with a first threaded portion, a coolant chamber disposed in the tip portion, and a coolant fluid conduit having a second threaded portion. The coolant fluid conduit is coupled to the tip portion adjacent to the coolant chamber via screwing of the second threaded portion into the first threaded portion.

Abstract: Gasifier preheater fuel and moderator injection apparatus, systems and methods are provided. A preheater distributor ring is securely mounted within the shell dome of a gasification vessel, for the selective discharge of preheat fuel and oxidizer into the vessel during preheating operations, or for the selective discharge of moderating agents into the vessel during normal gasification operations.

Abstract: A system includes a solids combining system with a solids mixing section having a mixing chamber and a plurality of solids inlets configured to supply one or more solids into the mixing chamber. The system also includes a solids breakup section having a plurality of fluid inlets configured to supply one or more fluids into the mixing chamber and a solids flow control section having a converging-diverging passage downstream of the mixing chamber.

Abstract: A system includes a gasification feed injector that includes a tip portion with a first threaded portion, a coolant chamber disposed in the tip portion, and a coolant fluid conduit having a second threaded portion. The coolant fluid conduit is coupled to the tip portion adjacent to the coolant chamber via screwing of the second threaded portion into the first threaded portion.

Abstract: Gasifier preheater fuel and moderator injection apparatus, systems and methods are provided. A preheater distributor ring is securely mounted within the shell dome of a gasification vessel, for the selective discharge of preheat fuel and oxidizer into the vessel during preheating operations, or for the selective discharge of moderating agents into the vessel during normal gasification operations.

Abstract: A system includes a rotary machine. The rotary machine has a spline joint coupling first and second rotary components. The spline joint has a male spline portion and a female spline portion. The male spline portion includes a first plurality of spline teeth spaced circumferentially apart from one another about a longitudinal axis of the spline joint. The female spline portion includes a second plurality of spline teeth spaced circumferentially apart from one another about the longitudinal axis of the spline joint. The first plurality of spline teeth and the second plurality of spline teeth extend axially along the longitudinal axis. At least one tooth of the first or second plurality of spline teeth has at least one groove extending crosswise relative to the longitudinal axis. The at least one groove is disposed at an intermediate axial position between opposite axial ends of the at least one tooth.

Abstract: A system includes a gasifier and a gasification fuel injector. The gasification fuel injector may include a tip portion, a coolant chamber disposed in the tip portion, and a number of internal structures disposed on an internal surface of the coolant chamber. The coolant chamber may be configured to flow a coolant through the tip portion of the gasification fuel injector.

Abstract: The present application and the resultant patent provide a feed injector nozzle for a gasification system with a reaction zone therein. The feed injector nozzle may include a number of tubes extending towards the reaction zone. The tubes may define a number of passages therebetween. A cooling water channel may extend through one of the tubes. The cooling water channel may include a first side adjacent to one of the passages and a second side adjacent to the reaction zone. The first side may include a first side thickness and the second side may include a second side thickness with the first side thickness being less than or equal to the second side thickness.