Abstract: Wearable uroflowmetry systems having wearable uroflowmeters are disclosed. A disclosed example uroflowmetry system comprises a wearable uroflowmeter including: a funnel portion having an end configured to secure the funnel portion against a person, an outlet opposite the end, and a funnel configured to capture urine excreted by the person when the end is secured against the person, and to direct the captured urine into the outlet; a fluid passage portion having an opening configured to receive the urine from the outlet of the funnel portion, and a fluid channel to pass the received urine along a length of the fluid passage portion; and a measuring portion having a sensor in the fluid channel configured to collect one or more measurements of the urine as the urine passes the sensor, the measurements representative of at least one of a property of the urine, or a flow characteristic of the urine.

Abstract: The present disclosure relates generally to security tags, and more specifically relates to electronic article surveillance (EAS) tags. The tag prevents unauthorized removal of an article as well as triggers an alarm when the tag is attempted for tampering. The tag comprises a housing, a switch, and a processing circuit. The switch includes a first contact coupled with the housing and a second contact coupled with an article. The second contact is movable relative to the first contact. The processing circuit is provided to detect electrical disconnection between the first contact and the second contact, and trigger an alarm upon detecting the electrical disconnection.

Abstract: Methods and systems are disclosed for automatically taking actions based on triggering events in market data using a filter component are disclosed. Market trading information is received, including one or more bids and one or more asks. An untriggered virtual order is received via a filter component of a graphical user interface (GUI), including a triggering event and associated action. Upon detecting, in the market trading information, an occurrence of the triggering event, the associated action is triggered. The action can include generating an alert and/or submitting an order to a marketplace based on the untriggered virtual order. In some implementations, the filter component can display a filtered portion of the market trading information, and an untriggered virtual order can be configured via the filter component by selecting a bid or ask.

Abstract: Systems, devices, and methods described herein relate to delivery of therapeutic agents. Such systems and devices can include needle-based delivery systems, in which a throttling assembly is configured to control a rate or needle insertion and/or a rate of drug extrusion.

Abstract: TROP2 binders and variants thereof are described. In a specific embodiment, the TROP2 binders that are antibodies that preferentially bind high-expressing TROP2 cells over low-expressing TROP2 cells and conjugates thereof comprising the TROP2 binders conjugated to a payload are described.

Abstract: Methods and systems are disclosed for automatically taking actions based on triggering events in market data using a filter component are disclosed. Market trading information is received, including one or more bids and one or more asks. An untriggered virtual order is received via a filter component of a graphical user interface (GUI), including a triggering event and associated action. Upon detecting, in the market trading information, an occurrence of the triggering event, the associated action is triggered. The action can include generating an alert and/or submitting an order to a marketplace based on the untriggered virtual order. In some implementations, the filter component can display a filtered portion of the market trading information, and an untriggered virtual order can be configured via the filter component by selecting a bid or ask.

Abstract: Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise a Bcl-xL inhibitor drug moiety. The disclosure farther relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising Bcl-xL inhibitor drug moiety and methods of making same are also disclosed.

Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: A joint mechanism includes a first end joint member; a middle joint member; a second end joint member; a first linkage member comprising a first annular band, the first linkage member pivotably coupled with the first end joint member and pivotably coupled with the middle joint member; and a second linkage member comprising a second annular band, the second linkage member pivotably coupled with the middle joint member and pivotably coupled with the second end joint member.

Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: The present invention relates to treatments of hereditary angioedema (HAE). In particular, the present invention provides on-demand treatments of hereditary angioedema (HAE) by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand.

Abstract: Systems and methods for minimally invasive computer-assisted telesurgery are described. For example, this disclosure describes computer-assisted teleoperated surgery instruments with cable-actuated joint mechanisms Some such joint mechanisms include linkages that maintain the joints in operable configurations without relying on cable tension to do so.

Abstract: A referential amplifier device includes an input port configured to be electrically coupled to a source to receive an input signal from the source at an input voltage level. A first current path system is coupled to the input port and comprises a first transconductor device, a third transconductor device, a first resistor device, and a second resistor device. A second current path system is in parallel with the first current path system and comprises a second transconductor device and a fourth transconductor device. A current level in the second transconductor device is set equal to a current level in the first transconductor device, and a current level in the second transconductor device is set equal to a current level in the fourth transconductor device. An output port is coupled to the second current path system and configured to provide an output voltage based on a difference between the input voltage level and a threshold voltage level for the referential amplifier device.

Abstract: Disposable absorbent articles suitable for providing leakage protection for users that experience relatively small to relatively large discharges of fluids are described. The article includes a primary topsheet, a backsheet, and an absorbent system disposed between the topsheet and the backsheet. The absorbent system includes a first absorbent core and a second absorbent core, and wherein the primary topsheet and at least the first absorbent core include a plurality of recessed areas.

Abstract: The present invention relates to treatments of bradykinin-mediated angioedema. In particular, the present invention provides on-demand treatments of bradykinin-mediated angioedema by orally administering a plasma kallikrein inhibitor to a patient in need thereof on-demand as an oral dosage form particularly suitable for patients who may struggle to swallow tablets.

Abstract: Disclosed herein are systems and methods for scalable and secure transmission of multicast data over a public communication network. In exemplary embodiments of the present disclosure, a virtual overlay network can be presented as a single virtual interface to a computing device, for the receipt and transfer of multicast data in a secure and scalable manner across a public insecure communication network.

Abstract: Systems and methods for coupling a tag to an item. The methods comprise: dispensing the tag from a tag feeder of a tag applicator; performing first operations by the tag applicator to mechanically move the tag into a nest of the tag applicator; determining if a given criteria is met based on feedback information received from at least one of a user of the tag applicator and a sensor provided with the tag applicator; and performing second operations by the tag applicator to couple the tag to the item, when a determination is made that the given criteria is met.

Abstract: Systems and methods for coupling a tag to an item. The methods comprise: dispensing the tag from a tag feeder of a tag applicator; performing first operations by the tag applicator to mechanically move the tag into a nest of the tag applicator; determining if a given criteria is met based on feedback information received from at least one of a user of the tag applicator and a sensor provided with the tag applicator; and performing second operations by the tag applicator to couple the tag to the item, when a determination is made that the given criteria is met.

Abstract: Provided here are therapeutically effective pharmaceutical compositions containing one or more TREX2 inhibitors, and more specifically methods of administering TREX2 inhibitors to increase the effectiveness of a chemotherapeutic agent. Also provided here are methods of identifying agents that inhibit the exonuclease activity of TREX2.

Abstract: Methods and systems are disclosed for generating a view of data to emphasize similar orders or patterns. Based on a pattern associated with a particular characteristic in a set of data, at least a subset of a plurality of data groupings to display is determined. For a particular subset of data groupings to display, a first graphical object is generated. A second graphical object represents an executable algorithm. After detecting user input causing a change in placement of the second graphical object in relation to the first graphical object, an automatic operation indicated by the executable algorithm is executed in connection with an item in the at least one order grouping indicated by the first graphical object.