Patents by Inventor Edward R. Aig
Edward R. Aig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11331596Abstract: A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments. The system can include at-column dilution at trapping and separating stages thereof. A chromatography method for operating the chromatographic system includes measuring a plurality of time segments corresponding to a plurality of peaks of a fluid sample flowing through the first chromatographic column, and sequentially fluidly coupling the plurality of distinct flow segments with the corresponding plurality of traps during time segments corresponding to the plurality of peaks.Type: GrantFiled: September 16, 2020Date of Patent: May 17, 2022Assignee: Waters Technologies CorporationInventors: Amanda B. Dlugasch, Thomas E. Wheat, Daniel Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
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Publication number: 20200406165Abstract: A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments. The system can include at-column dilution at trapping and separating stages thereof. A chromatography method for operating the chromatographic system includes measuring a plurality of time segments corresponding to a plurality of peaks of a fluid sample flowing through the first chromatographic column, and sequentially fluidly coupling the plurality of distinct flow segments with the corresponding plurality of traps during time segments corresponding to the plurality of peaks.Type: ApplicationFiled: September 16, 2020Publication date: December 31, 2020Applicant: Waters Technologies CorporationInventors: Amanda B. Dlugasch, Thomas E. Wheat, Daniel Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
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Patent number: 10799813Abstract: A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments. The system can include at-column dilution at trapping and separating stages thereof. A chromatography method for operating the chromatographic system includes measuring a plurality of time segments corresponding to a plurality of peaks of a fluid sample flowing through the first chromatographic column, and sequentially fluidly coupling the plurality of distinct flow segments with the corresponding plurality of traps during time segments corresponding to the plurality of peaks.Type: GrantFiled: January 25, 2017Date of Patent: October 13, 2020Assignee: Waters Technologies CorporationInventors: Amanda B. Dlugasch, Thomas E. Wheat, Daniel Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
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Patent number: 10668406Abstract: The present disclosure relates to an enhanced multi-dimensional chromatography system and method using selectable At-Column Dilution to improve compatibility of the interface and transfer between the multiple dimensions. The use of At-Column Dilution (“ACD”) with multi-dimensional chromatography can provide greater retention of the diverted components on subsequent stationary phases, and increase the sensitivity and peak shape of the component(s) separated on subsequent dimensions.Type: GrantFiled: January 20, 2017Date of Patent: June 2, 2020Assignee: Waters Technologies CorporationInventors: Amanda B. Dlugasch, Thomas E. Wheat, Dan Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
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Publication number: 20170209812Abstract: The present disclosure relates to an enhanced multi-dimensional chromatography system and method using selectable At-Column Dilution to improve compatibility of the interface and transfer between the multiple dimensions. The use of At-Column Dilution (“ACD”) with multi-dimensional chromatography can provide greater retention of the diverted components on subsequent stationary phases, and increase the sensitivity and peak shape of the component(s) separated on subsequent dimensions.Type: ApplicationFiled: January 20, 2017Publication date: July 27, 2017Applicant: Waters Technologies CorporationInventors: Amanda B. Dlugasch, Thomas E. Wheat, Dan Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
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Publication number: 20170209811Abstract: A chromatography system includes a first chromatography column for receiving and separating a flow stream, a plurality of traps configured to trap a plurality of distinct flow segments exiting the first chromatography column during separation of the flow stream, and a second chromatography column operatively associated with the plurality of traps for receiving and separating the distinct flow segments. The system can include at-column dilution at trapping and separating stages thereof. A chromatography method for operating the chromatographic system includes measuring a plurality of time segments corresponding to a plurality of peaks of a fluid sample flowing through the first chromatographic column, and sequentially fluidly coupling the plurality of distinct flow segments with the corresponding plurality of traps during time segments corresponding to the plurality of peaks.Type: ApplicationFiled: January 25, 2017Publication date: July 27, 2017Inventors: Amanda B. Dlugasch, Thomas E. Wheat, Daniel Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
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Patent number: 4894480Abstract: The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modifying anti-rheumatic agents and as immunosuppressants.Type: GrantFiled: December 16, 1988Date of Patent: January 16, 1990Assignee: Hoffmann-La Roche Inc.Inventors: Edward R. Aig, John W. Coffey, Allen J. Lovey, Michael Rosenberger
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Patent number: 4883614Abstract: The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modifying anti-rheumatic agents and as immunosuppressants.Type: GrantFiled: October 24, 1986Date of Patent: November 28, 1989Assignee: Hoffman-La Roche Inc.Inventors: Edward R. Aig, John W. Coffey, Allen J. Lovey, Michael Rosenberger
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Patent number: 4883613Abstract: The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modifying anti-rheumatic agents and as immunosuppressants.Type: GrantFiled: July 31, 1987Date of Patent: November 28, 1989Assignee: Hoffmann-La Roche Inc.Inventors: Edward R. Aig, John W. Coffey, Allen J. Lovey, Michael Rosenberger
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Patent number: 4780251Abstract: The compounds 9-phenyl-3,7-dimethyl-2,4,6,8-nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modifying anti-rheumatic agents and as immunosuppressants.Type: GrantFiled: October 23, 1986Date of Patent: October 25, 1988Assignee: Hoffman-La Roche Inc.Inventors: Edward R. Aig, John W. Coffey, Allen J. Lovey, Michael Rosenberger
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Patent number: 4648996Abstract: The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modifying anti-rheumatic agents and as immunosuppressants.Type: GrantFiled: June 20, 1985Date of Patent: March 10, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Edward R. Aig, John W. Coffey, Allen J. Lovey, Michael Rosenberger