Patents by Inventor Edward R. Lavagnino

Edward R. Lavagnino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serotonin and norepinephrine uptake inhibitors
    Patent number: 4902710
    Abstract: The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, which are capable of selectively inhibiting the uptake of serotonin and norepinephrine.
    Type: Grant
    Filed: December 14, 1988
    Date of Patent: February 20, 1990
    Assignee: Eli Lilly and Company
    Inventors: Bennie J. Foster, David C. Hunden, Edward R. Lavagnino
  • Isoquinoline derivatives as immune regulants
    Patent number: 4670442
    Abstract: This invention provides for certain substituted 7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-ones, formulations of the compounds, and a method for their use in suppressing the immune response in mammals.
    Type: Grant
    Filed: August 10, 1983
    Date of Patent: June 2, 1987
    Assignee: Eli Lilly and Company
    Inventors: Jack B. Campbell, Edward R. Lavagnino
  • Thienothienylglycyl cephalosporin derivatives
    Patent number: 4581352
    Abstract: 7-(Thienothienyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: April 8, 1986
    Assignee: Eli Lilly and Company
    Inventors: Bennie J. Foster, David C. Hunden, Edward R. Lavagnino
  • Process for the synthesis of intermediates in the preparation of diaminopyridines
    Patent number: 4552967
    Abstract: The present invention relates to a process for preparing aminonitropyridines comprising reacting an alkoxynitropyridine with ammonium acetate.
    Type: Grant
    Filed: January 12, 1984
    Date of Patent: November 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: James M. Greene, Edward R. Lavagnino, Andrew J. Pike, Edward C. Taylor
  • Benzothienylglycyl cephalosporin derivatives
    Patent number: 4482553
    Abstract: 7-(2-Benzothienyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: November 13, 1984
    Assignee: Eli Lilly and Company
    Inventors: Robin D. G. Cooper, Bernard J. Graves, Edward R. Lavagnino
  • Preparation of isoquinoline derivatives useful as immune regulants
    Patent number: 4413126
    Abstract: This invention provides for a process of preparing certain trifluoromethyl substituted 7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-ones.
    Type: Grant
    Filed: June 9, 1982
    Date of Patent: November 1, 1983
    Assignee: Eli Lilly and Company
    Inventors: Jack B. Campbell, Edward R. Lavagnino
  • 9-Carbamoyl-9-(2-cyanoethyl)fluorenes
    Patent number: 4282170
    Abstract: 9-Carbamoyl-9-(2-cyanoethyl)fluorenes are intermediates for synthesis of 9-aminoalkyl-9-carbamoyl-fluorenes, which are antiarrhythmic agents.
    Type: Grant
    Filed: April 17, 1980
    Date of Patent: August 4, 1981
    Assignee: Eli Lilly and Company
    Inventors: Edward R. Lavagnino, Andrew J. Pike, Jack B. Campbell
  • 1-Phenyl-3-(substituted phenoxy)propylamines
    Patent number: 4207343
    Abstract: 1-Phenyl-3-(optionally substituted phenoxy)-propylamines, inhibitors of norepinephrine uptake.
    Type: Grant
    Filed: June 22, 1978
    Date of Patent: June 10, 1980
    Assignee: Eli Lilly and Company
    Inventors: Edward R. Lavagnino, Lawrence J. McShane, Bryan B. Molloy
  • 9-Amino-dibenzopyrans
    Patent number: 4195025
    Abstract: 1-Hydroxy-3-substituted-tetrahydro and hexahydrodibenzo[b,d]pyrans having an amino group or amino derivative at the 9-position are useful as analgesics, anti-depressants, anti-anxiety agents, hypotensive agents, and intermediates. Pharmaceutical formulations containing such 9-amino derivatives are provided, as well as a method of treating hypertension.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: March 25, 1980
    Assignee: Eli Lilly and Company
    Inventors: William A. Day, Edward R. Lavagnino
  • Trifluoromethylphenyl benzyl ethers
    Patent number: 4168388
    Abstract: Trifluoromethylphenols are prepared by hydrogenation of the corresponding trifluoromethylbenzylethers.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: September 18, 1979
    Assignee: Eli Lilly and Company
    Inventors: Edward R. Lavagnino, Bryan B. Molloy, Paul Pranc
  • 9-Amino-dibenzopyrans
    Patent number: 4152450
    Abstract: 1-Hydroxy-3-substituted-tetrahydro and hexahydrodibenzo[b,d]pyrans having an amino group or amino derivative at the 9-position are useful as analgesics, anti-depressants, anti-anxiety agents, hypotensive agents, and intermediates. Pharmaceutical formulations containing such 9-amino derivatives are provided, as well as a method of treating hypertension.
    Type: Grant
    Filed: February 17, 1978
    Date of Patent: May 1, 1979
    Assignee: Eli Lilly and Company
    Inventors: William A. Day, Edward R. Lavagnino
  • Process for preparing dl-cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H -dibenzo[b,d]pyran-9-ones
    Patent number: 4148809
    Abstract: Reaction of a 5-substituted resorcinol with a 1-alkoxy-4-(1-hydroxy-1-methylethyl)-1,4-cyclohexadiene in the presence of a suitable catalyst affords the corresponding dl-cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-d ibenzo[b,d]pyran-9-one.
    Type: Grant
    Filed: September 8, 1977
    Date of Patent: April 10, 1979
    Assignee: Eli Lilly and Company
    Inventors: William A. Day, Edward R. Lavagnino
  • Preparation of N-2-(6-hydroxybenzothiazolyl)-N'-phenyl (or substituted-phenyl) ureas
    Patent number: 3932435
    Abstract: N-2-(6-hydroxybenzothiazolyl)-N'-phenyl (or substituted-phenyl) ureas are prepared by reacting 2-amino-6-hydroxybenzothiazole with 1-2 moles of phenyl (or a substituted phenyl) isocyanate and then hydrolysing any 6-phenylcarbamoyloxy compound thus produced to the corresponding 6-hydroxy derivative.
    Type: Grant
    Filed: August 30, 1974
    Date of Patent: January 13, 1976
    Assignee: Eli Lilly and Company
    Inventors: Edward R. Lavagnino, Charles J. Paget, James H. Wikel