Patents by Inventor Edward R. LaVallie

Edward R. LaVallie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aggrecanase molecules
    Publication number: 20030228676
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: December 30, 2002
    Publication date: December 11, 2003
    Inventors: Michael J. Agostino, Elizabeth DiBlasio, Edward R. Lavallie, Bethany A. Freeman, Lisa A. Racie, Weilan Zeng
  • HUMAN SDF-5 PROTEIN AND COMPOSITIONS
    Publication number: 20030175855
    Abstract: Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
    Type: Application
    Filed: October 15, 1997
    Publication date: September 18, 2003
    Inventors: EDWARD R. LAVALLIE, LISA A. RACIE
  • Novel proteins
    Publication number: 20030166044
    Abstract: Novel proteins are disclosed.
    Type: Application
    Filed: March 30, 2001
    Publication date: September 4, 2003
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy
  • Aggrecanase molecules
    Publication number: 20030148306
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: July 5, 2002
    Publication date: August 7, 2003
    Inventors: Michael J. Agostino, Elizabeth Di Blasio, Edward R. LaVallie, Lisa A. Racie
  • SECRETED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20030096951
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: May 22, 2003
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MICHAEL J. AGOSTINO, ROBERT STEININGER, VIKKI SPAULDING, GORDON G. WONG, HILARY F. CLARK, KIM FECHTEL, CHERYL EVANS, MAURICE TREACY
  • Polynucleotides encoding novel secreted proteins
    Publication number: 20030027139
    Abstract: Isolated polynucleotides which have been derived from a variety of human tissue sources, and which encode novel secreted proteins, are provided. Also provided are methods for producing proteins using these polynucleotides, and the proteins so produced.
    Type: Application
    Filed: March 29, 2001
    Publication date: February 6, 2003
    Inventors: Kenneth Jacobs, John McCoy, Edward R. LaVallie, Lisa Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Michael R. Bowman, Vikki Spaulding, Gordon G. Wong, Hilary F. Clark, Kim Fechtel, Steven H. Howes, Richard J. Resnick, Kalmalakar Gulukota, James R. Graham
  • HUMAN CHORDIN-RELATED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20020197666
    Abstract: Novel human chordin-related proteins and polynucleotides encoding them are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: December 26, 2002
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MAURICE TREACY, ELIZABETH DIBLASIO-SMITH, ANGELA WIDOM
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020193567
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Applicant: Genetics institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael R. Bowman, Vikki Spaulding, McKeough Carlin-Duckett, Kerry Kelleher
  • Secreted expressed sequence tags (sESTs)
    Publication number: 20020173635
    Abstract: Secreted expressed sequence tags (sESTs) isolated from a varie
    Type: Application
    Filed: January 7, 2002
    Publication date: November 21, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Secreted proteins
    Publication number: 20020165151
    Abstract: Novel proteins and methods of treatment using same are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: November 7, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, Maurice Treacy, Cheryl Evans, Michael J. Agostino, Zhijian Lu, David Merberg, Kei Tashiro, Tomoyuki Nakamura, Tasuku Honjo
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020146769
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: October 10, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding
  • Secreted proteins
    Publication number: 20020106356
    Abstract: Novel proteins are disclosed.
    Type: Application
    Filed: August 28, 2001
    Publication date: August 8, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020065394
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 22, 2000
    Publication date: May 30, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Vikki Spaulding
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20010039335
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: December 4, 2000
    Publication date: November 8, 2001
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Collins-Racie, Cheryl Evans, David Merberg, Maurice Treacy, Michael J. Agostino, Robert J. Steininger, Vikki Spaulding, Gordon G. Wong, Hilary Clark, Kim Fechtel
  • Secreted proteins and polynucleotides encoding them
    Patent number: 6312921
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 6, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, Cheryl Evans, David Merberg, Sha Mi, Maurice Treacy
  • Method of inhibiting angiogenesis using secreted proteins
    Patent number: 6280739
    Abstract: Novel proteins are disclosed.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: August 28, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • METHOD OF TREATMENT WITH A SECRETED PROTIEN
    Publication number: 20010016650
    Abstract: Novel proteins and methods of treatment using sameare disclosed.
    Type: Application
    Filed: May 21, 1998
    Publication date: August 23, 2001
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, LISA A. RACIE, EDWARD R. LAVALLIE, MAURICE TREACY, CHERYL EVANS, MICHAEL J. AGOSTINO, ZHIJIAN LU, DAVID MERBERG, KEI TASHIRO, TOMOYUKI NAKAMURA, TAKUKU HONJO
  • Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
    Patent number: 6143524
    Abstract: Provided is a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to a DNA sequence encoding a second peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of the molecule. The fusion molecule may be modified to introduce one or more metal-binding/chelating amino-acid residues to aid in purification. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: November 7, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: John McCoy, Elizabeth DiBlasio-Smith, Kathleen Grant, Edward R. LaVallie
  • Human L105 polypeptides and polynucleotides encoding same
    Patent number: 6084071
    Abstract: A chemokine, human L105, is disclosed.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: July 4, 2000
    Assignee: Genetics Institute
    Inventors: Lisa A. Racie, Kenneth Jacobs, Zhijian Lu, Edward R. LaVallie, John M. McCoy
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5985602
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: November 16, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Cheryl Evans