Patents by Inventor Edward Rebar
Edward Rebar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11834686Abstract: Described herein are DNA-editing complexes, particularly DNA-editing complexes that specifically alter a single base pair in target DNA sequence as well as methods of making and using these DNA-editing complexes.Type: GrantFiled: August 20, 2019Date of Patent: December 5, 2023Assignee: Sangamo Therapeutics, Inc.Inventors: Friedrich Fauser, Jeffrey C. Miller, Edward Rebar
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Publication number: 20220064237Abstract: Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).Type: ApplicationFiled: January 15, 2020Publication date: March 3, 2022Inventors: Galen Carey, Matthew Chiocco, Vivian Choi, Brian Felice, Steven Froelich, Debra Klatte, Jeffrey Miller, David Paschon, Edward Rebar, Bryan Zeitler, Lei Zhang, H. Steve Zhang
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Publication number: 20200063114Abstract: Described herein are DNA-editing complexes, particularly DNA-editing complexes that specifically alter a single base pair in target DNA sequence as well as methods of making and using these DNA-editing complexes.Type: ApplicationFiled: August 20, 2019Publication date: February 27, 2020Inventors: Friedrich Fauser, Jeffrey C. Miller, Edward Rebar
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Patent number: 9238803Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.Type: GrantFiled: July 13, 2006Date of Patent: January 19, 2016Assignee: Sangamo BioSciences, Inc.Inventors: Edward Rebar, Andrew Jamieson
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Patent number: 9234188Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.Type: GrantFiled: July 13, 2006Date of Patent: January 12, 2016Assignee: Sangamo BioSciences, Inc.Inventors: Edward Rebar, Andrew Jamieson
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Patent number: 9234187Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.Type: GrantFiled: January 22, 2002Date of Patent: January 12, 2016Assignee: Sangamo BioSciences, Inc.Inventors: Edward Rebar, Andrew Jamieson
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Patent number: 8383766Abstract: The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5?-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity.Type: GrantFiled: August 15, 2007Date of Patent: February 26, 2013Assignee: Sangamo BioSciences, Inc.Inventors: Qiang Liu, Edward Rebar, Andrew C. Jamieson
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Patent number: 8071564Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.Type: GrantFiled: September 3, 2009Date of Patent: December 6, 2011Assignee: Sangamo Biosciences, Inc.Inventors: Edward Rebar, Andrew Jamieson, Qiang Liu, Pei-Qi Liu, Alan Wolffe, Stephen P. Eisenberg, Eric Jarvis
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Patent number: 7947873Abstract: Disclosed herein are zinc finger proteins that bind to target sites in a plant gamma-tocopherol methyl transferase (GMT) gene; compositions comprising these GMT-targeted zinc finger proteins and methods of making and using such zinc finger proteins. Also disclosed are methods for modulating the alpha-tocopherol content in various plant organs, particularly seeds, in transgenic plants.Type: GrantFiled: April 17, 2003Date of Patent: May 24, 2011Assignee: Sangamo Biosciences, Inc.Inventors: Guofu Li, Qiang Liu, Andrew Jamieson, Edward Rebar, Mylavarapu Venkatramesh
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Publication number: 20100093838Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.Type: ApplicationFiled: September 3, 2009Publication date: April 15, 2010Applicant: Sangamo BioSciences, Inc.Inventors: Edward Rebar, Andrew Jamieson, Qiang Liu, Pei-Qi Liu, Alan Wolffe, Stephen P. Eisenberg, Eric Jarvis
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Patent number: 7605140Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.Type: GrantFiled: April 26, 2005Date of Patent: October 20, 2009Assignee: Sangamo Biosciences, Inc.Inventors: Edward Rebar, Andrew Jamieson, Qiang Liu, Pei-Qi Liu, Alan Wolffe, Stephen P. Eisenberg, Eric Jarvis
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Patent number: 7585849Abstract: The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5?-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity.Type: GrantFiled: August 11, 2005Date of Patent: September 8, 2009Assignee: Sangamo Biosciences, Inc.Inventors: Qiang Liu, Edward Rebar, Andrew C. Jamieson
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Patent number: 7560440Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.Type: GrantFiled: July 14, 2006Date of Patent: July 14, 2009Assignee: Sangamo Bioschiences, Inc.Inventors: Edward Rebar, Andrew Jamieson, Qiang Liu, Pei-Qi Liu, Alan Wolffe, Stephen P. Eisenberg, Eric Jarvis
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Publication number: 20080242847Abstract: The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location of its target subsite within a larger target sequence. The present disclosure provides zinc finger amino acid sequences for recognition of triplet target subsites having the nucleotide G in the 5?-most position of the subsite, that have been optimized with respect to the location of the subsite within the target site. Accordingly, the disclosure provides finger position-specific amino acid sequences for the recognition of GNN target subsites. This allows the construction of multi-finger zinc finger proteins with improved affinity and specificity for their target sequences, as well as enhanced biological activity.Type: ApplicationFiled: August 15, 2007Publication date: October 2, 2008Inventors: Qiang Liu, Edward Rebar, Andrew C. Jamieson
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Publication number: 20070287189Abstract: The invention provides criteria and methods for selecting optimum subsequence(s) from a target gene for targeting by a zinc finger protein. Some of the methods of target site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5?NNGK3?. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.Type: ApplicationFiled: February 12, 2007Publication date: December 13, 2007Applicant: Sangamo BioSciences, Inc.Inventors: Stephen Eisenberg, Casey Case, George Cox lll, Andrew Jamieson, Edward Rebar
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Publication number: 20070134796Abstract: Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.Type: ApplicationFiled: July 26, 2006Publication date: June 14, 2007Inventors: Michael Holmes, Fyodor Urnov, Philip Gregory, Edward Rebar, Sean Brennan
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Publication number: 20070072818Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.Type: ApplicationFiled: July 14, 2006Publication date: March 29, 2007Applicant: Sangamo BioSciences, Inc.Inventors: Edward Rebar, Andrew Jamieson, Qiang Liu, Pei-Qi Liu, Alan Wolffe, Stephen Eisenberg, Eric Jarvis
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Patent number: 7177766Abstract: The invention provides criteria and methods for selecting optimum subsequence(s) from a target gene for targeting by a zinc finger protein. Some of the methods of target site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5?NNGK3?. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.Type: GrantFiled: April 2, 2001Date of Patent: February 13, 2007Assignee: Sangamo Biosciences, Inc.Inventors: Stephen Eisenberg, Casey Case, George Cox, III, Andrew Jamieson, Edward Rebar
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Publication number: 20060292621Abstract: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.Type: ApplicationFiled: July 12, 2006Publication date: December 28, 2006Applicant: Sangamo BioSciences, Inc.Inventors: Casey Case, Edward Rebar, Andrew Jamieson
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Publication number: 20060246567Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.Type: ApplicationFiled: July 13, 2006Publication date: November 2, 2006Applicant: Sangamo BioSciences, Inc.Inventors: Edward Rebar, Andrew Jamieson