Abstract: The invention relates to a device for determining two or more respiratory parameters relating to an individual and a method for determining two or more respiratory parameters relating to an individual by means of the device. The disclosed device and method may be used in an individual suffering from pulmonary gas exchange problems relating to gas exchange of oxygen and/or carbon dioxide, e.g. a patient with chronic obstructive pulmonary disease. The device and method may also be used in a healthy individual or in an animal, e.g. for research experiments. The device has detection means for oxygen and carbon dioxide contents in inspired and expired gas and blood.

Abstract: The disclosed invention relates to a fire sprinkler shut-off tool for stopping water flow from an activated fire sprinkler head. Due to the lack of any automatic safety release mechanisms, such tools currently on market suffer the disadvantage of requiring constant monitoring in case fire rekindles. The shut-off tool comprising a pair of adjustable clamping arms and an actuator assembly for adjusting and fixing the clamping arms addresses the safety issue by integrating a fusible link locking tab into the actuator assembly. The presence of a nearby fire melts and separates the locking tab thereby releasing the clamping arms from an activated fire sprinkler head. The shut-off tool also addresses the safety problem of firemen or building maintenance personnel using a shut-off device that requires two hands while working from a ladder as this device can be easily used with one hand.

Abstract: A feeding bottle (10) comprises a container (16), a teat (12) and a collar (14) to screw the teat (12) onto and seal the container (16). A vent assembly (18) is mounted between the teat (12) and the container (16) and includes a vent tube (22) passing down to a position close to the base of the container (16) and having a one way valve (34) allowing air to pass into the container (16) on application of suction to the teat (12) but preventing liquid flowing into the vent tube (22), together with a valve flange (36) acting as an anti-choke member.

Abstract: A methodology for converting venous blood values to arterial blood values provides the advantage of obviating the need for taking arterial blood samples. The method entails (i) measuring arterial oxygenation, (ii) measuring and estimating values of venous blood acid/base status and oxygenation status of a venous blood sample, and (iii) converting the venous blood values by applying a mathematical model for deriving blood acid/base status and oxygenation status into estimated arterial blood values.

Abstract: A feeding bottle (10) comprises a container (16), a teat (12) and a collar (14) to screw the teat (12) onto and seal the container (16). A vent assembly (18) is mounted between the teat (12) and the container (16) and includes a vent tube (22) passing down to a position close to the base of the container (16) and having a one way valve (34) allowing air to pass into the container (16) on application of suction to the teat (12) but preventing liquid flowing into the vent tube (22), together with a valve flange (36) acting as an anti-choke member.

Abstract: The present invention relates to methods of reducing cartilage degradation in a patient comprising administering to a patient in need thereof an effective amount of an antibody antagonist to the mature form of OSM.

Abstract: The present invention relates to pharmaceutical compositions comprising a unit dose of at least 1 mg of an antibody to oncostatin M (OSM) and a pharmaceutically acceptable carrier. In some aspects, the pharmaceutical composition comprises an antibody that blocks OSM from interacting with OSM receptor gp130.

Abstract: The present invention relates to receptor/reporter fusion protein based assays for detecting an effect test compounds have on a particular membrane receptor, as well as to receptor/reporter fusion proteins for use in such assays and compounds identified by the assays as having interesting/useful effects. Suitable membrane receptors are growth factor receptors, cytokine receptors, ion channels and integrins including any subtypes, mutants, homologs and chimeric forms of such receptors. The assay is particularly suited to studying G-protein coupled receptors (GPCRs).

Abstract: A baby bib comprises a body portion (2) of a plastics material above which is formed an opening (8) to receive the baby's neck, the rear surface of the body portion (2) being embossed to provide areas of relief (14) for engagement with the baby's skin. Preferably the bib is of a flexible plastics material which can be rolled up and retained in a compacted condition.

Abstract: The present invention relates to the use of an antagonist of OSM such as an antibody or small molecule in the manufacture of a medicament for the treatment or prophylaxis of an inflammatory arthropathy or inflammatory disorder, and the use of OSM in screening for such antagonists.

Abstract: A device for determining one or more respiratory parameters relating to an individual is disclosed, as well as a method for determining one or more respiratory parameters by means of the device, wherein the individual is suffering from hypoxemia or is at risk of hypoxemia. However, the method and the device may also be applied to healthy individual e.g. for testing of medicaments. The device is controlled by a computer equipped with suitable software and includes functionality for on-line continuous data collection, automatic assessment of the timing of measurements, automatic assessment of the next target (oxygen saturation of arterial blood (SpO2)), automatic assessment of the appropriate fraction of oxygen in inspired gas (FIO2) settings to achieve the target SpO2, automatic control of the FIO2, on-line parameter estimation, and automatic assessment of the number of measurememts requied.

Abstract: A drinking vessel includes a cover and a mouthpiece, the mouthpiece having at least a flexible portion which in its unflexed state engages a plug extending up through the mouthpiece. When the flexible portion is flexed, for example by suction or pressing or biting with lips or teeth the flexible portion flexes out of engagement with the plug, forming a liquid passage. As a result a self-sealing drinking vessel is provided which provides liquid on user demand.

Abstract: A baby's bib comprises a body portion (2) of a semi-rigid plastics material in which is formed an opening (14) for the baby's neck, a bead (16) of a plastics material softer than that of the body portion (2) being secured around part at least of the opening (14), the attachment of the bead (16) to the body portion (2) being such as to permit radial compression of the bead (16) but to prevent longitudinal extension of the bead (16).

Abstract: A drinking vessel includes a cover and a mouthpiece, the mouthpiece having at least a flexible portion which in its unflexed state engages a plug extending up through the mouthpiece. When the flexible portion is flexed, for example by suction or pressing or biting with lips or teeth the flexible portion flexes out of engagement with the plug, forming a liquid passage. As a result a self-sealing drinking vessel is provided which provides liquid on user demand.

Abstract: A container for liquid, and in particular a baby's feeding bottle, comprises a bounding wall (2) defining a hollow interior to the container, part (6) of said bounding wall (2) consisting of a material which undergoes a change in color when the temperature thereof reaches a predetermined value.