Abstract: The invention provides a compound of formula (I) or a salt thereof: wherein Ar has the sub-formula (x) or (z): and wherein R3 is optionally substituted C3-8cycloalkyl, optionally substituted C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc), or a bicyclic group (ee); and wherein R4 is H, C1-3alkyl, C1-2fluoroalkyl, cyclopropyl, —CH2OR4a, —CH(Me)OR4a, or —CH2CH2OR4a; and R5 is inter alia H, C1-8alkyl, C1-3fluoroalkyl, C3-8cycloalkyl, certain substituted alkyl groups, —(CH2)n13-Het, or optionally substituted phenyl or —CH2-Ph; or R4 and R5 taken together are —(CH2)p1— or —(CH2)p3—X5—(CH2)p4—; provided that at least one of R4 and R5 is not a hydrogen atom (H). The invention also provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, allergic rhinitis or atopic dermatitis.

Abstract: A clearinghouse receives medical-related financial data, including data describing payment claims for medical services from a provider and payment polices and explanations of benefits (EOBs) from a payer. The clearinghouse aggregates the data into logical units, such as family units. A translation module translates codes in the EOBs or other data into layperson descriptions. An end-user uses a client computer to download the aggregated medical-related financial data from the clearinghouse. An analytics module at the client computer analyzes the medical-related financial data to identify items of interest to the end-user, such as billing and payment errors, and available tax deductions. The end-user can input personal medical data and the analytics module will correlate the medical data with the medical services identified by the financial data.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (26). The assembly is brazed together.

Abstract: An improved surface for detecting low-energy radiation particles has high performance phosphor particles partially embedded into a light guide material to optically couple the light guide material and the phosphor particles. This arrangement addresses photon signal losses, which occur when phosphor particles rest upon the surface of the light guide. The improved optical coupling enables the photons generated by the phosphor particles to be efficiently transferred to the light guide, and then to a photomultiplier tube or other device as required.

Abstract: Prodrugs of formula I, their uses, their intermediates, and their method of manufacture are described: wherein: V, W, and W? are independently selected from the group consisting of —H, alkyl, aralkyl, alicyclic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, 1-alkenyl, and 1-alkynyl; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group containing 5-7 atoms, optionally 1 heteroatom, substituted with hydroxy, acyloxy, alkoxycarbonyloxy, or aryloxycarbonyloxy attached to a carbon atom that is three atoms from both O groups attached to the phosphorus; or together V and Z are connected via an additional 3-5 atoms to form a cyclic group, optionally containing 1 heteroatom, that is fused to an aryl group at the beta and gamma position to the O attached to the phosphorus; together V and W are connected via an additional 3 carbon atoms to form an optionally substituted cyclic group containing 6 carbon atoms and substituted with one substituent selected from the group co

Abstract: Novel purine compounds of Formula 1, pharmaceutically acceptable prodrugs and salts thereof, and their use as fructose 1,6-bisphosphatase inhibitors.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (34). The assembly is brazed together.

Abstract: The present invention includes a group of novel compounds that are demonstrated to potently and selectively inhibit HIV integrase (IN) activity in vitro and to potently inhibit HIV replication in live, cultured cells at non-toxic concentrations. The novel compounds disclosed include 2,3-di(3,4-dihydroxy-dihydroxydihydrocinnamoyl)-L-tartaric acid, 2,3-di-(3,4-dihydroxybenzoyl)-L-tartaric acid, 2,3-di-(3,4-dihydroxyphenylacetyl)-L-tartaric acid, 2,3-di-(3,4,5-trihydroxybenzoyl-L-tartaric acid, 2,3-dicaffeoyldiamidopropionic acid, 1,2,-dicaffeoyl-L-glyceric acid, bis,-3,4-dicaffeoyldiamidobenzoic acid, di-3,4-dihydroxybenzylidene succinic acid, di-3,4-dihydrodihydroxybenzylidine succinic acid, 2,3-dicaffeoyl-L-serine, bis-dicaffeoyl-L-isoserine and 1,4-dicaffeoyl-L-lysine. Tests of integrase inhibitors with 2?,3?-dideoxycytidine, zidovudine and nelfinavir (protease inhibitor) indicated a potent synergy against reverse transcriptase inhibitor resistant virus.

Abstract: Water treatment involves delivering an instantaneous electric current to one or more pairs of activated electrodes immersed in the water, each of the pairs of electrodes comprising a sacrificial electrode operating predominantly as an anode and an inert electrode operating predominantly as a cathode. The sacrifical electrode, when as an anode, is able to provide dissolved ions to the water as current passes between the pairs of electrodes, to assist in treating the water. The polarity of the electrodes is periodically reversed to reduce electrode clogging. The amount of charge passed by the instantaneous electric current is indicative of the degree to which the water has been treated, and is used to control the treatment process.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (26). The assembly is brazed together.

Abstract: A coupling system for a vehicle such as an articulated lorry and method of use thereof is provided. The articulated lorry includes at least a tractor unit and a trailer unit. The tractor unit has first coupling means provided on a fifth wheel which engages with second coupling means typically in the form of a kingpin on the trailer unit. The fifth wheel coupling means and the kingpin have one or more pneumatic and/or electrical supply lines provided therein which engage upon mechanical engagement of the fifth wheel coupling means and kingpin, thereby allowing pneumatic and/or electrical supply between said tractor unit and said trailer unit and/or vice versa. One of the fifth wheel coupling means or kingpin is provided with one or more annular protrusions on a coupling surface and the other is provided with complementary annular channels on a coupling surface.

Abstract: A heat exchanger includes a flattened tube 10 having a plurality of internal ports 22 extending to the end 12 thereof. A cap 14 includes a slot 28 which receives the tube 10, and the cap 14 in turn is received in a tank 16. The construction is easy to assemble and assures that the ports 22 in the tube 10 will not be blocked during the assembly process.

Abstract: Water treatment involves delivering an instantaneous electric current to one or more pairs of activated electrodes immersed in the water, each of the pairs of electrodes comprising a sacrificial electrode operating predominantly as an anode and an inert electrode operating predominantly as a cathode. The sacrifical electrode, when as an anode, is able to provide dissolved ions to the water as current passes between the pairs of electrodes, to assist in treating the water. The polarity of the electrodes is periodically reversed to reduce electrode clogging. The amount of charge passed by the instantaneous electric current is indicative of the degree to which the water has been treated, and is used to control the treatment process.

Abstract: Heat exchange inefficiencies found in round tube plate fin heat exchangers are eliminated in an aluminum heat exchanger that includes first and second headers (20), (22) and at least one flattened tube (24), (70) extending between the headers (20), (22). A plurality of generally parallel tube runs are defined and each has opposite edges. A plurality of plate fins (26), (50) are arranged in a stack and each has a plurality of open ended slots (34), one for each run of the tubes (24), (70). Each of the tube runs (24), (70) is nested within corresponding slots (26) and the fins (26), (50) with one of the edges (40) of the tube runs extending outwardly of the corresponding fin (26). The assembly is brazed together.

Abstract: A viscometer for sensing or characterizing the stress required to shear a fluid at a given rate includes a pair of members coaxially mounted for relative rotation. Between the members is an annular gap defining a flow path for the fluid. The flow path is configured such that during differential rotation of the members, fluid is caused to flow through the annular gap that is a function of the differential rotation and the viscosity of the fluid. A sensor measures the torque or torque equivalent required to achieve such differential rotation between the members.

Abstract: A method, apparatus, and article of manufacture for locating web pages from a network server. A count of retrievals of a web page is accumulated and the accumulated count and an address for the web page are stored in a record of a history log database at the network server. A multiple reference hotlist is formatted from the records in the history log database, wherein the multiple reference hotlist comprises a list of addresses for web pages retrieved from the records and the list is sorted by the accumulated counts retrieved from the records. The multiple reference hotlist is then displayed for a user.

Abstract: The energy required to provide hot water may be reduced in a water heating system including a heat generating range (12) for cooking food and a hood (14) overlying the range (12) for capturing fumes rising from the range (12) or the food thereon. An exhaust duct (16) provided with an exhaust fan (18) is connected to the hood (14) and a baffle and heat exchanger assembly (22) is interposed between the hood (14) and the exhaust duct (16). The assembly (22) includes a grease collecting baffle (54) facing the hood (14) and a heat exchanger (52) backing the baffle (54). The heat exchanger (52) includes a liquid flow path (56), (60), (74) through which water to be heated by the fumes may circulate.

Abstract: The energy required to provide hot water may be reduced in a water heating system including a heat generating range (12) for cooking food and a hood (14) overlying the range (12) for capturing fumes rising from the range (12) or the food thereon. An exhaust duct (16) provided with an exhaust fan (18) is connected to the hood (14) and a baffle and heat exchanger assembly (22) is interposed between the hood (14) and the exhaust duct (16). The assembly (22) includes a grease collecting baffle (54) facing the hood (14) and a heat exchanger (52) backing the baffle (54). The heat exchanger (52) includes a liquid flow path (56), (60), (74) through which water to be heated by the fumes may circulate.

Abstract: An apparatus for sealing a covering material to an outer flange of a container includes a container carrier for aligning the covering material relative to the container so that a portion of the covering material is positioned over the outer flange of the container. The apparatus also includes a sealing assembly having a horn and a mechanism for applying pressure to the outer flange and to the covering material against the horn. The apparatus further includes a conveyor for moving the container carrier relative to the sealing assembly so that the outer flange of the container and the portion of the covering material positioned over the outer flange pass below the horn. In addition, the apparatus includes a mechanism for vibrating the horn at a predetermined frequency to cause friction between the outer flange of the container and the portion of the covering material positioned over the outer flange to seal the outer flange to the covering material.