Patents by Inventor Edward S. Boyden

Edward S. Boyden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240287627
    Abstract: The invention, in some aspects, include methods and systems for temporally multiplexed imaging (TMI).
    Type: Application
    Filed: February 27, 2024
    Publication date: August 29, 2024
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Yong Qian, Edward S. Boyden
  • Publication number: 20240269286
    Abstract: Provided are compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.
    Type: Application
    Filed: August 23, 2023
    Publication date: August 15, 2024
    Inventors: Alan Horsager, Kenneth Greenberg, Benjamin C. Matteo, Edward S. Boyden, Douglas G. Ririe, James C. Eisenach, Christian Wentz
  • Publication number: 20240150413
    Abstract: In aspects, the invention provides novel compositions and methods for dominant inhibition of viral infection.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 9, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Alexi G. Choueiri, Yong Qian, Bowen Li, Robert S. Langer, Daniel G. Anderson, Edward S. Boyden
  • Publication number: 20230414102
    Abstract: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
    Type: Application
    Filed: September 7, 2023
    Publication date: December 28, 2023
    Inventors: Paul G. Allen, Edward S. Boyden, Mahalaxmi Gita Bangera, W. Daniel Hillis, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K.Y. Jung, Eric C. Leuthardt, Dennis J. Rivet, Michael A. Smith, Elizabeth A. Sweeney, Lowell L. Wood, JR., Victoria Y.H. Wood
  • Publication number: 20230332207
    Abstract: The invention relates, in part, to methods of unified expansion microscopy (uniExM) permitting multimodal detection of biomolecules.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 19, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Yi Cui, Gaojie Yang, Edward S. Boyden
  • Patent number: 11771763
    Abstract: The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: October 3, 2023
    Assignees: EOS NEUROSCIENCE, INC., WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: Alan Horsager, Kenneth Greenberg, Benjamin C. Matteo, Edward S. Boyden, Douglas G. Ririe, James C. Eisenach, Christian Wentz
  • Publication number: 20230250139
    Abstract: The invention, in some aspects, includes compositions encoding expression-recording islands (XRIs), compositions comprising XRIs, and methods for using XRIs for intracellular molecular recording.
    Type: Application
    Filed: October 11, 2022
    Publication date: August 10, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Changyang Linghu, Edward S. Boyden
  • Patent number: 11564701
    Abstract: An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that automatically controls the drilling apparatus, the positioning device, and the detection device. A method for automated opening of craniotomies includes, under automatic control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. Determining conductance may include use of an impedance detection circuit.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: January 31, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Nikita Pak, Justin P. Kinney, Edward S. Boyden
  • Patent number: 11542314
    Abstract: The invention, in some aspects relates to light-activated ion channel molecules and methods for their use to alter cell activity and function. Light-activated ion channel molecules of the invention can be administered to subjects, expressed in cells, and activated with light, to alter membrane potential in the cells, and can be used in methods for assaying compounds, treating diseases and conditions, compound screening and more.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: January 3, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Aimei Yang, Demian Park, Edward S. Boyden
  • Publication number: 20220163515
    Abstract: A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific RNA base. The chains can bind arbitrary RNA sequences with high specificity and fidelity by varying the sequence of modules within the chains. Each module contains at least 6 amino acids, with the amino acids in positions 1 and 5 providing the preferred affinity for the specific base, and the amino acid at position 2 serving as a stacking unit between concatenated modules. The modules may have four canonic forms, each having a preferred affinity for a different base and characterized by the base with which it has affinity, the two amino acids that provide the affinity, and the amino acid that serves as a stacking unit.
    Type: Application
    Filed: February 9, 2022
    Publication date: May 26, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward S. Boyden, Katarzyna P. Adamala, Daniel Alberto Martin-Alarcon
  • Publication number: 20220126257
    Abstract: A method for synthesizing nanoparticles by sonofragmentation includes dispersing ultra-thin substrate units in a solvent chosen for suitability for sonofragmentation of the substrate, forming a suspension; ultrasonicating the suspension for a length of time sufficient to fragment the substrate into nanoparticles that are dispersed in the solvent; and evaporating the solvent. Solvent exchange with a second solvent may be performed. The synthesized nanoparticles are highly crystalline and monodispersed. The surface of the synthesized nanoparticles may be functionalized by choosing the solvents according to chemistry related to the intended surface functionalization of the synthesized nanoparticles, by adding surfactants to one or more of the solvents, and/or by performing ligand exchange or chemical modification to replace surface-bonded solvent or surfactant molecules with other functional groups to produce nanoparticles having the desired surface functionalization.
    Type: Application
    Filed: September 1, 2021
    Publication date: April 28, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Ruixuan Gao, Ishan Gupta, Edward S. Boyden
  • Publication number: 20220112553
    Abstract: Methods for single-molecule analysis of structure and sequence of linearized polynucleotides are provided.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 14, 2022
    Applicants: Massachusetts Institute of Technology, The Broad Institute, Inc.
    Inventors: Edward S. Boyden, Fei Chen, Nikita Obidin, Andrew Colin Payne
  • Patent number: 11275081
    Abstract: A programmable modular protein architecture for RNA binding comprises a set of modules, derived from RNA-binding protein Pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific RNA base. The chains can bind arbitrary RNA sequences with high specificity and fidelity by varying the sequence of modules within the chains. Each module contains at least 6 amino acids, with the amino acids in positions 1 and 5 providing the preferred affinity for the specific base, and the amino acid at position 2 serving as a stacking unit between concatenated modules. The modules may have four canonic forms, each having a preferred affinity for a different base and characterized by the base with which it has affinity, the two amino acids that provide the affinity, and the amino acid that serves as a stacking unit.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: March 15, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward S. Boyden, Katarzyna P. Adamala, Daniel Alberto Martin-Alarcon
  • Publication number: 20220048970
    Abstract: The invention, in some aspects, relates to polypeptide molecules and their encoding nucleic acid molecules and use of such molecules to direct and localize sensor molecules in the soma of cells in which they are expressed. Compositions of the invention may be delivered to cells and subjects and used in methods to determine activity in cells in which they are expressed.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 17, 2022
    Inventors: Or A. Shemesh, Changyang Linghu, Kiryl D. Piatkevich, Edward S. Boyden, Won Min Park
  • Patent number: 11214661
    Abstract: The present invention enables three-dimensional nanofabrication by isotropic shrinking of patterned hydrogels. A hydrogel is first expanded, the rate of expansion being controlled by the concentration of the crosslinker. The hydrogel is then infused with a reactive group and patterned in three dimensions using a photon beam through a limited-diffraction microscope. Functional particles or materials are then deposited on the pattern. The hydrogel is then shrunk and cleaved from the pattern.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: January 4, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Samuel G. Rodriques, Daniel Oran, Ruixuan Gao, Shoh Asano, Mark A. Skylar-Scott, Fei Chen, Paul W. Tillberg, Adam H. Marblestone, Edward S. Boyden
  • Publication number: 20210298769
    Abstract: An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that automatically controls the drilling apparatus, the positioning device, and the detection device. A method for automated opening of craniotomies includes, under automatice control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. Determining conductance may include use of an impedance detection circuit.
    Type: Application
    Filed: November 3, 2020
    Publication date: September 30, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Nikita Pak, Justin P. Kinney, Edward S. Boyden
  • Patent number: 10993634
    Abstract: In an automated methodology for in vivo image-guided cell patch clamping, a cell patch clamping device is moved into position and targeted to a specific cell using automated image-guided techniques. Cell contact is determined by analyzing the temporal series of measured resistance levels at the clamping device as it is moved. The difference between successive resistance levels is compared to a threshold, which must be exceeded before cell contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically locating cells through image guidance and by analyzing the temporal sequence of electrode impedance changes.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: May 4, 2021
    Assignees: Massachusetts Institute of Technology, Georgia Tech Research Corporation
    Inventors: Ho-Jun Suk, Edward S. Boyden, Ingrid van Welie, Brian Douglas Allen, Suhasa B. Kodandaramaiah, Craig R. Forest
  • Publication number: 20210069329
    Abstract: The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.
    Type: Application
    Filed: June 27, 2019
    Publication date: March 11, 2021
    Inventors: Alan Horsager, Kenneth Greenberg, Benjamin C. Matteo, Edward S. Boyden, Douglas G. Ririe, James C. Eisenach, Christian Wentz
  • Patent number: 10820914
    Abstract: A method for automated opening of craniotomies includes, under the control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that controls the drilling apparatus, the positioning device, and the detection device according to the method. Determining conductance may include use of an impedance detection circuit.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: November 3, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Nikita Pak, Justin P. Kinney, Edward S. Boyden
  • Patent number: 10765817
    Abstract: Devices, systems, and methods that may be used to controllably deliver alcohol to a subject using an inhaler, wherein the inhaler may include a housing having a flow channel coupled to an ethanol-containing inhalant reservoir, an actuator configured to facilitate release of the inhalant, a constituent sensor, and a control unit. The control unit may accept parameters associated with the subject, create an inhalant delivery regime, and control operation of the actuator based at least partially on a sensed constituent level to facilitate release of an ethanol-containing inhalant from the reservoir into the flow channel in accordance with the regimen.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: September 8, 2020
    Assignee: Elwha, LLC
    Inventors: Edward S. Boyden, Roderick A. Hyde, Jordin T. Kare, Tony S. Pan, Robert C. Petroski, Elizabeth A. Sweeney, Lowell L. Wood, Jr.