Patents by Inventor Edward S. Schulman

Edward S. Schulman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Culturing Human Lung Mast Cells and Uses Thereof
    Publication number: 20090176880
    Abstract: Methods for culturing human lung mast cells in the absence of co-culture with feeder cells which are viable for longer than 4 days are provided. Also provided are methods for using these human lung mast cell cultures to assess biological and pharmacological activities of these cells in vivo and to identify modulators of the survival, proliferation, function and phenotypic expression of human lung mast cells. Modulators identified via these cells are useful in the prevention and treatment of diseases involving human lung mast cell function.
    Type: Application
    Filed: March 12, 2009
    Publication date: July 9, 2009
    Inventor: Edward S. Schulman
  • Methods for culturing human lung mast cells and uses thereof
    Patent number: 7524679
    Abstract: Methods for culturing human lung mast cells in the absence of co-culture with feeder cells which are viable for longer than 4 days are provided. Also provided are methods for using these human lung mast cell cultures to assess biological and pharmacological activities of these cells in vivo and to identify modulators of the survival, proliferation, function and phenotypic expression of human lung mast cells. Modulators identified via these cells are useful in the prevention and treatment of diseases involving human lung mast cell function.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: April 28, 2009
    Assignee: Philadelphia, Health and Education Corporation
    Inventor: Edward S. Schulman
  • Methods for culturing human lung mast cells and uses thereof
    Publication number: 20040014208
    Abstract: Methods for culturing human lung mast cells in the absence of co-culture with feeder cells which arc viable for longer than 4 days are provided. Also provided are methods for using these human lung mast cell cultures to assess biological and pharmacological activities of these cells in vivo and to identify modulators of the survival, proliferation, function and phenotypic expression of human lung mast cells. Modulators identified via these cells are useful in the prevention and treatment of diseases involving human lung mast cell function.
    Type: Application
    Filed: June 20, 2003
    Publication date: January 22, 2004
    Inventor: Edward S. Schulman
  • Screening method for modulation of human mast cell activation
    Patent number: 6465441
    Abstract: Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesireable mast cell mediator release, such as asthma and allergy. Inhibitors of ATP binding to mast cell P2-purinoceptors are useful therapeutic agents for treatments of those disorders. Methods of treatment using agents, and in vitro screening assays for selection of the therapeutic agents, are described.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: October 15, 2002
    Assignee: Duska Scientific Co.
    Inventors: Amir Pelleg, Edward S. Schulman
  • Screening method for modulation of human mast cell
    Publication number: 20020055515
    Abstract: Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesireable mast cell mediator release, such as asthma and allergy. Inhibitors of ATP binding to mast cell P2-purinoceptors are useful therapeutic agents for treatments of those disorders. Methods of treatment using agents, and in vitro screening assays for selection of the therapeutic agents, are described.
    Type: Application
    Filed: December 20, 2001
    Publication date: May 9, 2002
    Inventors: Amir Pelleg, Edward S. Schulman
  • Modulation of human mast cell activation
    Patent number: 6372724
    Abstract: Human mast cell activation is modulated by ATP binding to P2-purinoceptors on the mast cell surface. ATP binding to the purinoceptors provides a target for therapeutic intervention for the treatment of disorders characterized by undesirable mast cell mediator release, such as asthma and allergy. Inhibitors of ATP binding to mast cell P2-purinoceptors are useful therapeutic agents for treatment of those disorders. Methods of treatment using such agents, and in vitro screening assays for selection of the therapeutic agents, are described.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: April 16, 2002
    Assignee: Duska Scientific Co.
    Inventors: Amir Pelleg, Edward S. Schulman