Patents by Inventor Edward S. Smith
Edward S. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11993804Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: GrantFiled: December 19, 2019Date of Patent: May 28, 2024Assignee: Roche Molecular Systems, Inc.Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Publication number: 20200190560Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: ApplicationFiled: December 19, 2019Publication date: June 18, 2020Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Patent number: 10253308Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).Type: GrantFiled: November 20, 2017Date of Patent: April 9, 2019Assignee: Roche Molecular Systems, Inc.Inventors: Tomas R. Martinez, Edward S. Smith
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Patent number: 10035993Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: GrantFiled: July 6, 2017Date of Patent: July 31, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers
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Publication number: 20180142282Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: ApplicationFiled: June 30, 2017Publication date: May 24, 2018Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Publication number: 20180073008Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).Type: ApplicationFiled: November 20, 2017Publication date: March 15, 2018Inventors: Tomas R. Martinez, Edward S. Smith
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Patent number: 9868944Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).Type: GrantFiled: December 3, 2015Date of Patent: January 16, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Tomas R. Martinez, Edward S. Smith
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Publication number: 20170369856Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: ApplicationFiled: July 6, 2017Publication date: December 28, 2017Inventors: Keith A. BAUER, Ellen FISS, David Harrow GELFAND, Edward S. SMITH, Shawn SUKO, Thomas W. MYERS
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Patent number: 9738876Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: GrantFiled: January 20, 2015Date of Patent: August 22, 2017Assignee: Roche Molecular Systems, Inc.Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers
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Patent number: 9725754Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: GrantFiled: July 27, 2011Date of Patent: August 8, 2017Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Publication number: 20160230208Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.Type: ApplicationFiled: September 30, 2015Publication date: August 11, 2016Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicholas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen Will, Heike Wilts, Dirk Zimmerman
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Publication number: 20160177289Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).Type: ApplicationFiled: December 3, 2015Publication date: June 23, 2016Inventors: Tomas R. Martinez, Edward S. Smith
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Publication number: 20160024548Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors.Type: ApplicationFiled: July 27, 2015Publication date: January 28, 2016Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers, Joseph San Filippo, Rachel Shahinian
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Patent number: 9175332Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.Type: GrantFiled: July 27, 2011Date of Patent: November 3, 2015Assignee: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicolas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen G. Will, Heike Wilts, Dirk Zimmermann
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Patent number: 9102924Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: GrantFiled: April 16, 2009Date of Patent: August 11, 2015Assignee: Roche Molecular Systems, Inc.Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Olga Budker, Nancy Schoenbrunner, Susanne Stoffel, Thomas Myers
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Publication number: 20150218537Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: ApplicationFiled: January 20, 2015Publication date: August 6, 2015Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers
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Patent number: 8962293Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.Type: GrantFiled: October 17, 2007Date of Patent: February 24, 2015Assignee: Roche Molecular Systems, Inc.Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Thomas Myers
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Publication number: 20120190008Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.Type: ApplicationFiled: July 27, 2011Publication date: July 26, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicolas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen G. Will, Heike Wilts, Dirk Zimmermann
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Publication number: 20120045751Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: ApplicationFiled: July 27, 2011Publication date: February 23, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Publication number: 20110294168Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors.Type: ApplicationFiled: April 15, 2011Publication date: December 1, 2011Applicant: Roche Molecular Systems, Inc.Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Thomas Myers, Joseph San Filippo, Rachel Shahinian