Patents by Inventor Edward S. Smith

Edward S. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11993804
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: May 28, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Publication number: 20200190560
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 18, 2020
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Patent number: 10253308
    Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: April 9, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Tomas R. Martinez, Edward S. Smith
  • Patent number: 10035993
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: July 31, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers
  • Publication number: 20180142282
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Application
    Filed: June 30, 2017
    Publication date: May 24, 2018
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Publication number: 20180073008
    Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Application
    Filed: November 20, 2017
    Publication date: March 15, 2018
    Inventors: Tomas R. Martinez, Edward S. Smith
  • Patent number: 9868944
    Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 16, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Tomas R. Martinez, Edward S. Smith
  • Publication number: 20170369856
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Application
    Filed: July 6, 2017
    Publication date: December 28, 2017
    Inventors: Keith A. BAUER, Ellen FISS, David Harrow GELFAND, Edward S. SMITH, Shawn SUKO, Thomas W. MYERS
  • Patent number: 9738876
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: August 22, 2017
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers
  • Patent number: 9725754
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: August 8, 2017
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Publication number: 20160230208
    Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
    Type: Application
    Filed: September 30, 2015
    Publication date: August 11, 2016
    Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicholas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen Will, Heike Wilts, Dirk Zimmerman
  • Publication number: 20160177289
    Abstract: The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant DNA techniques, especially nucleic acid amplification by the polymerase chain reaction (PCR).
    Type: Application
    Filed: December 3, 2015
    Publication date: June 23, 2016
    Inventors: Tomas R. Martinez, Edward S. Smith
  • Publication number: 20160024548
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors.
    Type: Application
    Filed: July 27, 2015
    Publication date: January 28, 2016
    Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers, Joseph San Filippo, Rachel Shahinian
  • Patent number: 9175332
    Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: November 3, 2015
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicolas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen G. Will, Heike Wilts, Dirk Zimmermann
  • Patent number: 9102924
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects by an intercalating dye. Therefore, the mutant polymerases are useful in a variety of disclosed methods in combination with an intercalating dye. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: August 11, 2015
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Olga Budker, Nancy Schoenbrunner, Susanne Stoffel, Thomas Myers
  • Publication number: 20150218537
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Application
    Filed: January 20, 2015
    Publication date: August 6, 2015
    Inventors: Keith A. Bauer, Ellen Fiss, David Harrow Gelfand, Edward S. Smith, Shawn Suko, Thomas W. Myers
  • Patent number: 8962293
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: February 24, 2015
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Thomas Myers
  • Publication number: 20120190008
    Abstract: The present invention provides a method for the amplification of at least a first and a second target nucleic acid that may be present in a fluid sample. The invention further provides a kit and an analytical system for carrying out said amplification.
    Type: Application
    Filed: July 27, 2011
    Publication date: July 26, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Meike Eickhoff, Niclas Hitziger, Anke Mussmann, Thomas W. Myers, Christopher Newhouse, Nicolas Newton, John Niemiec, Nancy Schoenbrunner, Edward S. Smith, Stephen G. Will, Heike Wilts, Dirk Zimmermann
  • Publication number: 20120045751
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Application
    Filed: July 27, 2011
    Publication date: February 23, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Publication number: 20110294168
    Abstract: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. The mutant polymerases overcome the inhibitory effects of a variety of polymerase and reverse transcriptase inhibitors. Therefore, the mutant polymerases are useful in a variety of disclosed methods in the presence of such inhibitors.
    Type: Application
    Filed: April 15, 2011
    Publication date: December 1, 2011
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Keith A. Bauer, Ellen Fiss, David H. Gelfand, Edward S. Smith, Shawn Suko, Thomas Myers, Joseph San Filippo, Rachel Shahinian