Patents by Inventor Edward Semple

Edward Semple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating influenza
    Patent number: 11850237
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: December 26, 2023
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR COMPOUNDS AND USES THEREOF
    Publication number: 20230293539
    Abstract: Described herein are phenyl triazole and aniline compounds that are MLL1-WDR5 protein-protein interaction inhibitors. Also disclosed herein are pharmaceutical compositions and methods of use for the phenyl triazole and the aniline compounds.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 21, 2023
    Inventors: Farbod SHOJAEI, Che FANG, J. Edward SEMPLE, Mireille GILLINGS
  • HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Publication number: 20230286948
    Abstract: Described herein are a haloalkylpyridyl triazole MLL1-WDR5 protein-protein interaction inhibitors, pharmaceutical compositions and methods of use.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 14, 2023
    Inventors: Farbod SHOJAEI, J. Edward SEMPLE, Mireille GILLINGS
  • PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR
    Publication number: 20230286925
    Abstract: Described herein are a phenyl triazole MLL1-WDR5 protein-protein interaction inhibitors, pharmaceutical compositions and methods of use.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 14, 2023
    Inventors: Qidong YOU, Xiaoke GUO, Farbod SHOJAEI, Xin CHEN, J. Edward SEMPLE, Zhengyu JIANG, Xiaoli XU, Mireille GILLINGS
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20210177809
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: February 8, 2021
    Publication date: June 17, 2021
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 10912768
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: February 9, 2021
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20190307730
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 10, 2019
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 10363243
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: July 30, 2019
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Block copolymers for stable micelles
    Patent number: 9944752
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: April 17, 2018
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie, Joseph Edward Semple, Hooshmand Sheshbaradaran
  • Block copolymers for stable micelles
    Patent number: 9944754
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: April 17, 2018
    Assignee: Intezyne Technologies, Inc.
    Inventors: Kevin Sill, Joseph Edward Semple, Tomas Vojkovsky
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20180078533
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: November 16, 2017
    Publication date: March 22, 2018
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 9820975
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: November 21, 2017
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • BLOCK COPOLYMERS FOR STABLE MICELLES
    Publication number: 20170240703
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Application
    Filed: September 28, 2016
    Publication date: August 24, 2017
    Inventors: Kevin Sill, Joseph Edward Semple, Tomas Vojkovsky
  • BLOCK COPOLYMERS FOR STABLE MICELLES
    Publication number: 20160264732
    Abstract: The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 15, 2016
    Inventors: Kevin Sill, Tomas Vojkovsky, Adam Carie, Joseph Edward Semple, Hooshmand Sheshbaradaran
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20160228415
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: April 20, 2016
    Publication date: August 11, 2016
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Compounds and methods for treating influenza
    Patent number: 9345690
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: May 24, 2016
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • COMPOUNDS AND METHODS FOR TREATING INFLUENZA
    Publication number: 20150250768
    Abstract: This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
    Type: Application
    Filed: March 16, 2015
    Publication date: September 10, 2015
    Applicant: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: 9126992
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: September 8, 2015
    Assignee: Romark Laboratories, L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: RE46724
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: February 20, 2018
    Assignee: Romark Laboratories, L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple
  • Haloalkyl heteroaryl benzamide compounds
    Patent number: RE47786
    Abstract: A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 31, 2019
    Assignee: Romark Laboratories L.C.
    Inventors: Jean-Francois Rossignol, J. Edward Semple