Abstract: Methods and devices are disclosed for infrared phototherapy. The device can include a flexible substrate, a plurality of infrared light sources associated with the substrate and a drive circuitry configured to couple to a power supply and connected to the light sources to activate the light sources to emit infrared radiation. The device can be positioned on a subject's body to transmit infrared radiation to a target region of skin or muscle tissue of a subject to raise the temperature of the target region above normal body temperature. The plurality of light sources can be disposed in a spaced-apart relationship on the substrate such that collectively they emit infrared radiation in an overlapping pattern that provides for substantially uniform exposure of a target region. The substrate can be actively cooled to control the surface temperature of the target region. The device can further include a light-transmissive sealing element to isolate the LEDs from contact with the subject's body.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: An illumination device may include an illumination source including a light source, a single fiber connecting the illumination source to a medical device and being dedicated to the transmission of light energy from the light source, and a numerical aperture adjustment portion located between the single fiber and the medical device. The light source may generate at least one non-white colored laser energy, and the illumination device may convert the at least one non-white colored laser energy into white colored laser energy.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: An illumination device may include an illumination source including a light source, a single fiber connecting the illumination source to a medical device and being dedicated to the transmission of light energy from the light source, and a numerical aperture adjustment portion located between the single fiber and the medical device. The light source may generate at least one non-white colored laser energy, and the illumination device may convert the at least one non-white colored laser energy into white colored laser energy.

Abstract: A method and an apparatus according to an embodiment of the invention includes a reflector disposed within a capillary for use in side-firing optical fibers. An outer member or cap can be used to protect the capillary when being inserted through a catheter or endoscope. The endoscope is then at least partially inserted into a patient's body to provide laser-based medical treatment. In some embodiments, a multilayer dielectric coating can be disposed on an angled surface of the reflector. In other embodiments, a multilayer dielectric coating can be positioned between a distal end surface of the reflector and an inner side of a distal end portion of the capillary. The coated reflector can be configured to increase laser energy redirected from a first portion of an optical path to a second portion of the optical path that is non-parallel to the first portion.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: A method and an apparatus according to an embodiment of the invention includes a reflector and an optical fiber end portion disposed within a capillary for use in side-firing optical fibers. The reflector surface can be coated with a multilayer dielectric coating to increase the amount of side-fired laser energy. An outer member or cap can be used to protect the capillary when being inserted through a catheter or endoscope. The endoscope is then at least partially inserted into a patient's body to provide laser-based medical treatment. Multiple grooves can be defined on an outer surface of the optical fiber buffer layer to increase the surface area and improve the mechanical strength of the coupling between the optical fiber and the capillary. In some embodiments, the outer member or cap can also be coupled to the grooved surface portion of the optical fiber buffer layer.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: A method and an apparatus according to an embodiment includes a distal end portion of an optical fiber core having a multilayer dielectric coating. For side-firing optical fibers, the coating can be disposed on an angled surface at the core distal end to produce total internal reflection of laser energy at the angled surface. The coating can also be disposed on an outer surface of the distal end portion of the core. The coating and the angled surface can be collectively configured to redirect laser energy in a lateral or side-fired direction. For end-firing optical fibers, the coating can be disposed on an outer surface of the distal end portion of the core. The coating and a perpendicular surface at the core distal end can be collectively configured to direct laser energy in a direction substantially parallel to the distal end portion of the optical fiber.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: An optical delivery apparatus is disclosed including: an optical fiber extending between a distal end having a distal end face and a proximal end having a proximal end face, an optical element positioned to receive the light emitted from the distal end face and direct the light to an illumination region; and a non-metallic housing containing the optical fiber and the optical element and maintaining the relative position of the optical fiber and the optical element.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: A method and an apparatus according to an embodiment of the invention includes a reflector and an optical fiber end portion disposed within a capillary for use in side-firing optical fibers. The reflector surface can be coated with a multilayer dielectric coating to increase the amount of side-fired laser energy. An outer member or cap can be used to protect the capillary when being inserted through a catheter or endoscope. The endoscope is then at least partially inserted into a patient's body to provide laser-based medical treatment. Multiple grooves can be defined on an outer surface of the optical fiber buffer layer to increase the surface area and improve the mechanical strength of the coupling between the optical fiber and the capillary. In some embodiments, the outer member or cap can also be coupled to the grooved surface portion of the optical fiber buffer layer.

Abstract: A method and an apparatus according to an embodiment includes a distal end portion of an optical fiber disposed inside a lumen defined along a curved path within a capillary. The distal end surface of the optical fiber can be substantially flush with a portion of an outside surface of the capillary that defines a transmissive portion. The distal end portion of the optical fiber and the curved path can be collectively configured to direct laser energy through the transmissive portion in a lateral or side-fired direction that is offset from a longitudinal axis or centerline of the capillary. In some embodiments, more than one optical fiber can be disposed along the curved path. In other embodiments, more than one curved path can be defined within the capillary such that a distal end portion of an optical fiber can be disposed along each of the curved paths.

Abstract: An optical delivery apparatus is disclosed including: an optical fiber extending between a distal end having a distal end face and a proximal end having a proximal end face, an optical element positioned to receive the light emitted from the distal end face and direct the light to an illumination region; and a non-metallic housing containing the optical fiber and the optical element and maintaining the relative position of the optical fiber and the optical element.

Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

Abstract: A method and an apparatus according to an embodiment of the invention includes a reflector disposed within a capillary for use in side-firing optical fibers. An outer member or cap can be used to protect the capillary when being inserted through a catheter or endoscope. The endoscope is then at least partially inserted into a patient's body to provide laser-based medical treatment. In some embodiments, a multilayer dielectric coating can be disposed on an angled surface of the reflector. In other embodiments, a multilayer dielectric coating can be positioned between a distal end surface of the reflector and an inner side of a distal end portion of the capillary. The coated reflector can be configured to increase laser energy redirected from a first portion of an optical path to a second portion of the optical path that is non-parallel to the first portion.

Abstract: A method and an apparatus according to an embodiment includes a distal end portion of an optical fiber core having a multilayer dielectric coating. For side-firing optical fibers, the coating can be disposed on an angled surface at the core distal end to produce total internal reflection of laser energy at the angled surface. The coating can also be disposed on an outer surface of the distal end portion of the core. The coating and the angled surface can be collectively configured to redirect laser energy in a lateral or side-fired direction. For end-firing optical fibers, the coating can be disposed on an outer surface of the distal end portion of the core. The coating and a perpendicular surface at the core distal end can be collectively configured to direct laser energy in a direction substantially parallel to the distal end portion of the optical fiber.