Abstract: The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. For example, 5-(1H-indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. Antibiotic 75b antibiotic is bactericidal and is orally bioavailable. This class of antibiotics can be used as a therapeutic agent against infections by Gram-positive bacteria such as MRSA.

Abstract: The invention provides a newly discovered oxadiazole class of antibiotics. The oxadiazoles impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacteria such as the bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. For example, 5-(1H-indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. Antibiotic 75b antibiotic is bactericidal and is orally bioavailable. This class of antibiotics can be used as a therapeutic agent against infections by Gram-positive bacteria such as MRSA.

Abstract: In various embodiments, methods and systems for remotely customizing a virtual machine in a cloud computing infrastructure are provided. A VM agent component provided on a virtual machine, while in communication with a VM deployment service associated therewith, can be configured to detect an incoming configuration payload that corresponds to a selected one or more extension packages cataloged on a VM marketplace component in communication with the VM deployment service component. Employing the configuration payload, the VM agent component can initialize communication with the extension repository to retrieve the one or more extension packages for storage and installation onto the virtual machine. Upon installing the one or more extension packages, the VM agent component can be configured to communicate a status report to the VM deployment service component for provision to an administrator.

Abstract: In various embodiments, methods and systems for remotely customizing a virtual machine in a cloud computing infrastructure are provided. A VM agent component provided on a virtual machine, while in communication with a VM deployment service associated therewith, can be configured to detect an incoming configuration payload that corresponds to a selected one or more extension packages cataloged on a VM marketplace component in communication with the VM deployment service component. Employing the configuration payload, the VM agent component can initialize communication with the extension repository to retrieve the one or more extension packages for storage and installation onto the virtual machine. Upon installing the one or more extension packages, the VM agent component can be configured to communicate a status report to the VM deployment service component for provision to an administrator.

Abstract: In various embodiments, methods and systems for maintaining compatibility between applications, based on feature-set constraints are provided. A distributed computing system provides Platform as a service (PaaS) including a software framework in a service model of cloud computing. A known compatibility baseline is established for features of a first application and a second application. The known compatibility baseline inherently includes a baseline set of unenumerated features of the applications. It is determined that the first application is compatible with second application based on comparing an explicit enumeration of added features or removed features in a feature set of the applications. The added features or removed features are tracked after the baseline set of unenumerated features is defined. The determination whether the first application and the second application are compatible is communicated for processing the first application and/or the second application.

Abstract: In various embodiments, methods and systems for maintaining compatibility between applications, based on feature-set constraints are provided. A distributed computing system provides Platform as a service (PaaS) including a software framework in a service model of cloud computing. A known compatibility baseline is established for features of a first application and a second application. The known compatibility baseline inherently includes a baseline set of unenumerated features of the applications. It is determined that the first application is compatible with second application based on comparing an explicit enumeration of added features or removed features in a feature set of the applications. The added features or removed features are tracked after the baseline set of unenumerated features is defined. The determination whether the first application and the second application are compatible is communicated for processing the first application and/or the second application.

Abstract: Contaminant laden gas streams from wood product dryer operations, and other sources, are purified. The gas stream first is saturated with moisture by contacting the gas stream with fine liquid droplets which entrain particulates. The gas stream then is subjected to a plurality of separate particulate and liquid droplet removal steps before a droplet-free gas stream having substantially reduced particulate contaminant levels is passed to a burner for removal of volatile organic compounds from the gas stream.