Abstract: An injector is disclosed for injecting an injectable substance into at least one of the epidermal tissue and the dermal tissue of a subject. The injector includes an outer housing and a control member disposed within the outer housing. A needle head, which is configured to support a plurality of needles, is operatively coupled to the control member. First means are provided in communication with the control member and are configured to be driven by the control member for converting a movement of the control member into a movement of the needle head along an injection direction and toward an injecting position of the needle head. Second means are configured to move the needle head in a direction having a component that is normal to the injection direction and absent movement of the outer housing relative to the skin of the subject.

Abstract: An injector is disclosed for injecting an injectable substance into at least one of the epidermal tissue and the dermal tissue of a subject. The injector includes an outer housing and a control member disposed within the outer housing. A needle head, which is configured to support a plurality of needles, is operatively coupled to the control member. First means are provided in communication with the control member and are configured to be driven by the control member for converting a movement of the control member into a movement of the needle head along an injection direction and toward an injecting position of the needle head. Second means are configured to move the needle head in a direction having a component that is normal to the injection direction and absent movement of the outer housing relative to the skin of the subject.

Abstract: An injector is disclosed for injecting an injectable substance into at least one of the epidermal tissue and the dermal tissue of a subject. The injector includes an outer housing and a control member disposed within the outer housing. A needle head, which is configured to support a plurality of needles, is operatively coupled to the control member. First means are provided in communication with the control member and are configured to be driven by the control member for converting a movement of the control member into a movement of the needle head along an injection direction and toward an injecting position of the needle head. Second means are configured to move the needle head in a direction having a component that is normal to the injection direction and absent movement of the outer housing relative to the skin of the subject.

Abstract: The present invention provides a method of prophylaxis or treatment of a senescence-associated disease or disorder by administering to a subject in need thereof, a therapeutically effective amount of a NMT inhibitor.

Abstract: A method for determining a voltage based or current based state of charge (SOC) and state of health (SOH) of a battery system is provided. The method includes: providing a model of the battery system including an equivalent circuit having both low frequency and high frequency elements; establishing a plurality of functional relationships comprising relationship of the equivalent circuit with SOC; reducing at least part of the plurality of functional relationships into a set of time segmented recursive functional relationships, wherein a state at a first time t can be modeled by a functional presentation of a state at a second time t??t that occurred before the first time t; and computing a set of data points based upon the set of time segmented recursive functional relationships using a matrix for operation in matrix algebra.

Abstract: The present invention relates to a method of determining the probability that a statistical model describes the driving style or usage of a vehicle observed. By identifying an appropriate statistical model, the driving style can be detected and vehicle operation can be optimized. The method may be applied to both hybrid and non-hybrid vehicles. The method may also be augmented to determine the most probable statistical model of the usage of the vehicle. This allows detection of driving styles that can be classified as urban, highway, aggressive, etc. For example, the augmented method can be used to distinguish between highway and urban driving with a very high certainty.

Abstract: A method of modeling a cycle of a vehicle parameter includes generating a plurality of training sets and partially classifying elements of each training set based on a present value of the vehicle parameter and a subsequent change in the vehicle parameter. The method further includes reducing the plurality of training sets to a corresponding plurality of parameter sets based on the elements and defining a plurality of statistical groups of the parameter sets based on a value and a history of that value.

Abstract: A method of estimating a state of charge (SOC) and a state of health (SOH) of an electrochemical cell (EC) includes modeling the EC with a linear equation, measuring a terminal current of the EC, measuring a terminal voltage of the EC and measuring a temperature of the EC. The linear equation is processed through a time-varying state and parameter estimator based on the terminal current, the terminal voltage and the temperature to determine states and parameters of the EC.

Abstract: A state of charge estimator for a battery includes a meter that generates a terminal voltage signal of the battery and a terminal current signal of the battery. A controller employs a linearized model of the battery and a time-varying state estimator. The controller process a synthesized input based on the terminal current and the terminal voltage to estimate the battery state of charge.