Abstract: A multi-part composition comprises a curable part and a curing part. The curable part comprises a curable epoxy resin and a first silicate component. The curing part comprises a curing agent and a second silicate component. The curable part or the curing part include a chemical blowing agent. The first silicate component and the second silicate component are different. The multi-part composition further comprises water. When mixed and cured, the multi-part composition forms an epoxy-geopolymer hybrid foam.

Abstract: The invention provides novel antibacterial compounds of formulae IA, IB and IC as defined herein. Optionally, the antibacterial compounds can be bonded to a delivery agent that is capable of bonding to one or more structures on a bacterial cell membrane. The invention also provides the use of such compounds in treating or preventing bacterial infections, and processes for their synthesis.

Abstract: The invention provides novel antibacterial compounds of formulae IA, IB and IC as defined herein. Optionally, the antibacterial compounds can be bonded to a delivery agent that is capable of bonding to one or more structures on a bacterial cell membrane. The invention also provides the use of such compounds in treating or preventing bacterial infections, and processes for their synthesis.

Abstract: The invention provides a combination of an antibacterial agent and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the delivery agent is capable of binding to one or more structures on a bacterial cell membrane. The invention further provides the use of such combinations in treating or preventing bacterial infections.

Abstract: An exercise bike operable while remaining stationary on a support surface. The exercise bike includes a bicycle frame with a pedal assembly coupled to a clutch mechanism that is movable between an unlocked state in which the pedal assembly drives a wheel in a first rotational direction and rotates relative to the wheel in a second rotational direction, and a locked state in which the pedal assembly is rotationally fixed to the wheel to drive the wheel in the first rotational direction and the second rotational direction, and a handlebar assembly. The handlebar assembly is coupled to the bicycle frame and includes a handlebar and a locking mechanism. The locking mechanism is moveable between an unlocked position in which the handlebar is allowed to rotate about an axis, and a locked position in which the handlebar is restricted from rotating about the axis. A control module may move the locking mechanism and the clutch mechanism between their respective locked and unlocked states.

Abstract: The invention provides a combination of an antibacterial agent (in particular vancomycin or moenomycin) and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the delivery agent is capable of binding to one or more structures on a bacterial cell membrane. The invention further provides the use of such combinations in treating or preventing bacterial infections.

Abstract: Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (vd) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate kb, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.

Abstract: An exercise bike operable while remaining stationary on a support surface. The exercise bike includes a bicycle frame and a handlebar assembly. The handlebar assembly is coupled to the bicycle frame and includes a handlebar and a locking mechanism. The locking mechanism is moveable between an unlocked position in which the handlebar is allowed to rotate about an axis, and a locked position in which the handlebar is restricted from rotating about the axis.

Abstract: There is provided a computer-implemented method of providing an itinerary search result, the method including the steps of: (i) presenting in a computing device user interface events proximate to a selected date, wherein the events are obtained from a calendar on the device; (ii) providing a selectable option in the user interface to select an itinerary search corresponding at least in part to the presented calendar events; (iii) receiving a selection of the selectable option; (iv) sending an itinerary search request to a server; (v) receiving an itinerary search result from the server, and (vi) presenting the itinerary search result in the user interface on the device. Related devices, systems and computer program products are disclosed. Further methods, devices, systems, servers and computer program products which relate to travel arrangements are disclosed.

Abstract: The invention provides novel antibacterial compounds of formulae IA, IB and IC as defined herein. Optionally, the antibacterial compounds can be bonded to a delivery agent that is capable of bonding to one or more structures on a bacterial cell membrane. The invention also provides the use of such compounds in treating or preventing bacterial infections, and processes for their synthesis.

Abstract: Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (vd) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate kb, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.

Abstract: A coating system includes a vacuum chamber and a coating assembly. The coating assembly includes a vapor source, a substrate holder, a remote anode electrically coupled to the cathode target, and a cathode chamber assembly. The cathode chamber assembly includes a cathode target, an optional primary anode and a shield which isolates the cathode target from the vacuum chamber. The shield defines an opening for transmitting an electron emission current of a remote arc discharge from the cathode target to the remote anode that streams along the target face long dimension. A primary power supply is connected between the cathode target and the primary anode while a secondary power supply is connected between the cathode target and the remote anode. Characteristically, a linear remote anode dimension and a vapor source short dimension are parallel to a dimension in which an arc spot is steered along the cathode target.

Abstract: The invention provides a combination of an antibacterial agent (in particular vancomycin or moenomycin) and a delivery agent, in which the delivery agent is bonded, or capable of binding, to the antibacterial agent, and in which the delivery agent is capable of binding to one or more structures on a bacterial cell membrane. The invention further provides the use of such combinations in treating or preventing bacterial infections.

Abstract: There is provided a computer-implemented method of providing an itinerary search result, the method including the steps of: (i) presenting in a computing device user interface events proximate to a selected date, wherein the events are obtained from a calendar on the device; (ii) providing a selectable option in the user interface to select an itinerary search corresponding at least in part to the presented calendar events; (iii) receiving a selection of the selectable option; (iv) sending an itinerary search request to a server; (v) receiving an itinerary search result from the server, and (vi) presenting the itinerary search result in the user interface on the device. Related devices, systems and computer program products are disclosed. Further methods, devices, systems, servers and computer program products which relate to travel arrangements are disclosed.

Abstract: A vacuum coating and plasma treatment system includes a magnetron cathode with a long edge and a short edge. The magnetic pole of the magnetron results in an electromagnetic barrier. At least one remote arc discharge is generated separate from the magnetron cathode and in close proximity to the cathode so that it is confined within a volume adjacent to the magnetron target. The remote arc discharge extends parallel to the long edge of the magnetron target and is defined by the surface of the target on one side and the electromagnetic barrier on all other sides. There is a remote arc discharge cathode hood and anode hood extending over the arc discharge and across the short edge of the magnetron cathode. Outside of the plasma assembly is a magnetic system creating magnetic field lines which extend into and confine the plasma in front of the substrate.

Abstract: A coating system includes a vacuum chamber and a coating assembly. The coating assembly has a coating assembly which includes a vapor source, a substrate holder to hold substrates to be coated such that the substrates are positioned in front of the vapor source, a primary cathodic vacuum-arc assembly, a remote anode electrically coupled to the cathode target, a primary power supply connected between the cathode target and the primary anode, and a secondary power supply connected between the cathode target and the remote anode. The primary cathodic vacuum-arc assembly includes a cathode chamber assembly, a cathode target, an optional primary anode and a shield which isolates the cathode target from the vacuum chamber. The shield defines openings for transmitting either electron emission current or metal vapor plasma from the cathode target into the vacuum chamber. The vapor source is positioned between the cathode chamber assembly and the remote anode.

Abstract: A vacuum coating and plasma treatment system includes a magnetron cathode with a long edge and a short edge. The magnetic pole of the magnetron results in an electromagnetic barrier. At least one remote arc discharge is generated separate from the magnetron cathode and in close proximity to the cathode so that it is confined within a volume adjacent to the magnetron target. The remote arc discharge extends parallel to the long edge of the magnetron target and is defined by the surface of the target on one side and the electromagnetic barrier on all other sides. There is a remote arc discharge cathode hood and anode hood extending over the arc discharge and across the short edge of the magnetron cathode. Outside of the plasma assembly is a magnetic system creating magnetic field lines which extend into and confine the plasma in front of the substrate.

Abstract: A coating system includes a vacuum chamber and a coating assembly. The coating assembly includes a vapor source, a substrate holder, a remote anode electrically coupled to the cathode target, and a cathode chamber assembly. The cathode chamber assembly includes a cathode target, an optional primary anode and a shield which isolates the cathode target from the vacuum chamber. The shield defines an opening for transmitting an electron emission current of a remote arc discharge from the cathode target to the remote anode that streams along the target face long dimension. A primary power supply is connected between the cathode target and the primary anode while a secondary power supply is connected between the cathode target and the remote anode. Characteristically, a linear remote anode dimension and a vapor source short dimension are parallel to a dimension in which an arc spot is steered along the cathode target.

Abstract: An RF feed-through connector has a single pin or multi-pins supported and hermetically sealed between a first portion of the connector facing the hermetically sealed interior portion of an electronics-containing housing and a second portion of the connector exposed to ambient conditions in which the electronics-containing housing is placed. The invention is particularly directed to a new hermetically sealed RF feed-through connector architecture in which the connector's outer shell contains a relatively low coefficient of thermal expansion (CTE) portion that enables it to be soldered to a low CTE insert that supports one or more hermetically sealed longitudinal signal pins. The connector's outer shell also includes a relatively high CTE portion that allows the shell to be readily joined as by welding to an adjacent support structure, such as a relatively high CTE aluminum housing and the like.

Abstract: An RF feed-through connector has a single pin or multi-pins supported and hermetically sealed between a first portion of the connector facing the hermetically sealed interior portion of an electronics-containing housing and a second portion of the connector exposed to ambient conditions in which the electronics-containing housing is placed. The invention is particularly directed to a new hermetically sealed RF feed-through connector architecture in which the connector's outer shell contains a relatively low coefficient of thermal expansion (CTE) portion that enables it to be soldered to a low CTE insert that supports one or more hermetically sealed longitudinal signal pins. The connector's outer shell also includes a relatively high CTE portion that allows the shell to be readily joined as by welding to an adjacent support structure, such as a relatively high CTE aluminum housing and the like.