Abstract: In some embodiments, the present invention provides a method and an article for segregating solid support media or other solids, from liquid, while at the same time maintaining such solids and liquid in intimate contact as may be required for various processing or chemical operations. In an illustrative embodiment, the present article comprises a filter pocket plate consisting of a plate with a plurality holes. A foraminous material projects through each hole in the plate such that a “pocket” is formed within each hole. In use, the aforedescribed filter pocket plate engages a vessel having one or more wells suitable for retaining liquid and for receiving the filter pockets. The filter pockets contain a solid material that is to be exposed to the liquid in the well. After exposure is complete, the solid material is readily removed from the liquid by simply disengaging the filter pocket plate, which retains the solid support media, from the vessel, which retains the liquid.