Abstract: An autoinjector device and a method of use thereof for perispinal administration, comprising: a housing with an interspinous stop; a syringe assembly slidably mounted on the housing, the syringe assembly including a needle and a fluid container, an autoinjector actuator for urging the syringe assembly with respect to the housing from a storage position to a launch position wherein the needle travels through the interspinous stop; and a cap releasably engaged to the housing.

Abstract: An autoinjector device and a method of use thereof for perispinal administration, comprising: a housing with an interspinous stop; a syringe assembly slidably mounted on the housing, the syringe assembly including a needle and a fluid container; an autoinjector actuator for urging the syringe assembly with respect to the housing from a storage position to a launch position wherein the needle travels through the interspinous stop; and a cap releasably engaged to the housing.

Abstract: A method for delivering a biologic to a human with Alzheimer's-related dementia, comprising administering the biologic parenterally into the perispinal space of the human without direct intrathecal injection, and thereafter positioning the human's head below the horizontal. The method further includes delivering a TNF antagonist to the brain of a human for treating mild cognitive impairment, Alzheimer's related dementia, or vascular dementia, comprising administering the TNF antagonist golimumab parenterally into the perispinal space of the human without direct intrathecal injection, and thereafter positioning the human in a Trendelenburg position, for delivery of the golimumab to the brain via the human's vertebral venous system.

Abstract: Methods for treating neurological or neuropsychiatric diseases or disorders in humans by administering to the human a therapeutically effective dose of specific biologics are presented. The biologics of consideration include antagonists of tumor necrosis factor or of interleukin-1. The administration of these biologics is performed by specific methods, most, but not all of which fall into the category of anatomically localized administration designed for perispinal use. Anatomically localized administration involving perispinal use includes, but is not limited to the subcutaneous, intramuscular, interspinous, epidural, peridural, parenteral or intrathecal routes. Additonally, intranasal administration is discussed as a method to provide therapeutic benefit.

Abstract: Methods for treating bone metastases in humans by administering a therapeutically effective dose of specific biologics are presented. The biologics of consideration include antagonists of tumor necrosis factor or of interleukin-1; or biologic inhibitors of osteoclastogenesis, including OPG. The administration of these biologics is performed by specific methods, most of which fall into the category of anatomically localized injection designed for perilesional or intralesional use in proximity to the site of tumor metastasis to bone. Anatomically localized administration involving perilesional or intralesional use includes, but is not limited to, subcutaneous, intramuscular, interspinous, epidural, peridural, parenteral or perispinal administration.