Patents by Inventor Edward Touma

Edward Touma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7229779
    Abstract: A variant human ?7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human ?7 nAChR. Nucleic acid molecules encoding the variant human ?7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 12, 2007
    Assignee: Abbott Laboratories
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. Mc Kenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Publication number: 20040203033
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Application
    Filed: December 30, 2003
    Publication date: October 14, 2004
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. Mc Kenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Patent number: 6683157
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: January 27, 2004
    Assignee: Abbott Laboratories
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. Mc Kenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Publication number: 20030073161
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Application
    Filed: September 18, 2001
    Publication date: April 17, 2003
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. McKenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Patent number: 6323000
    Abstract: A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: November 27, 2001
    Inventors: Clark A. Briggs, Murali Gopalakrishnan, David G. McKenna, Lisa M. Monteggia, Jean-Marc Roch, James P. Sullivan, Edward Touma
  • Publication number: 20010006796
    Abstract: A variant human U7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.
    Type: Application
    Filed: December 20, 1996
    Publication date: July 5, 2001
    Inventors: CLARK A. BRIGGS, MURALI GOPALAKRISHNAN, DAVID G. MC KENNA, LISA M. MONTEGGIA, JEAN-MARC ROCH, JAMES P. SULLIVAN, EDWARD TOUMA