Patents by Inventor Edward W. Kraegen

Edward W. Kraegen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110152208
    Abstract: The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4(GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
    Type: Application
    Filed: January 14, 2009
    Publication date: June 23, 2011
    Applicants: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, The Garvan Institute of Medical Research, Australia
    Inventors: Yang Ye, David E. James, Minjia Tan, Gregory J. Cooney, Changqiang Ke, Edward W. Kraegen, Tong Chen, Jiming Ye, Xiqiang Li
  • Publication number: 20100113494
    Abstract: The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.
    Type: Application
    Filed: September 30, 2007
    Publication date: May 6, 2010
    Inventors: Lihong Hu, Jia Li, Jingya Li, Hankun Zhang, Zhe Cheng, Jiming Ye, David E. James, Edward W. Kraegen
  • Publication number: 20030212014
    Abstract: The long-term usage of AICR (5-aminio, 4-imidazole carboxamide riboside) to produce sustained metabolic and biological changes in mammals that overcome insulin resistance, i.e., increase insulin sensitivity, and result in benefits in diseases and conditions such as diabetes, hypertension, atherosclerosis, polycystic ovary syndrome and gallstones is described long-term usage of AICAR, particularly intermittent administration, e.g., three days per week, appears to have some of the positive effects of exercise, having an impact on the amount Of food consumed by a subject and resulting in reduced fat build-up and increase in muscle mass. Therefore, AICAR administration has a positive impact in reducing obesity. AICAR can also Prove useful in preventing or treating vascular diseases associated with hyperglycemia, high plasma levels of free fatty acids (FFA) and triglyceride, and insulin resistance by virtue of the fact that this agent activates fatty acid oxidation.
    Type: Application
    Filed: March 12, 2003
    Publication date: November 13, 2003
    Inventors: Neil Ruderman, Edward W Kraegen, Yasuo Ido
  • Patent number: 4475901
    Abstract: There is provided an apparatus to improve control of blood sugars in diabetics. The apparatus comprises an infusion means and a control means which controls the infusion rate of one or more diabetics control liquids. The control means comprises a basal rate means to control infusion of the liquid according to an assessed basal metabolic requirement and a non-basal rate means to control infusion of the liquid at one or more levels of metabolic activity. The control means is preferably adapted to receive patient data to vary the infusion of the liquid accordingly.
    Type: Grant
    Filed: November 6, 1981
    Date of Patent: October 9, 1984
    Assignees: The Garvan Research Development Ltd., The Commonwealth of Australia
    Inventors: Edward W. Kraegen, Leslie Lazarus, David J. Bell, Donald J. Chisholm