Patents by Inventor Edward W. Martin

Edward W. Martin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11350965
    Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: June 7, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Alper Yilmaz, Edward W. Martin, Stephen P. Povoski, Charles L. Hitchcock, Enver Ozer, Ronald Xu
  • Patent number: 10919979
    Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: February 16, 2021
    Assignee: Ohio State Innovation Foundation
    Inventors: Thomas J. Magliery, Brandon J. Sullivan, Heather C. Allen, Edward W. Martin, Charles L. Hitchcock, E. David Alten, Nicholas E. Long
  • Publication number: 20190321065
    Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 24, 2019
    Inventors: Alper Yilmaz, Edward W. Martin, Stephen P. Povoski, Charles L. Hitchcock, Enver Ozer, Ronald Xu
  • Patent number: 10383654
    Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: August 20, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Alper Yilmaz, Edward W. Martin, Stephen P. Povoski, Charles L. Hitchcock, Enver Ozer, Ronald Xu
  • Publication number: 20190110687
    Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate normal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g.
    Type: Application
    Filed: March 16, 2017
    Publication date: April 18, 2019
    Applicant: Ohio State Innovation Foundation
    Inventors: James COE, Heather ALLEN, Charles HITCHCOCK, Edward W. MARTIN
  • Publication number: 20180037663
    Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
    Type: Application
    Filed: July 31, 2017
    Publication date: February 8, 2018
    Inventors: Thomas J. Magliery, Brandon J. Sullivan, Heather C. Allen, Edward W. Martin, Charles L. Hitchcock, E. David Alten, Nicholas E. Long
  • Patent number: 9718888
    Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
    Type: Grant
    Filed: July 23, 2014
    Date of Patent: August 1, 2017
    Assignee: Ohio State Innovation Foundation
    Inventors: Thomas J. Magliery, Brandon J. Sullivan, Heather C. Allen, Edward W. Martin, Charles L. Hitchcock, E. David Alten, Nicholas E. Long
  • Publication number: 20160176979
    Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
    Type: Application
    Filed: July 23, 2014
    Publication date: June 23, 2016
    Inventors: Thomas J. Magliery, Brandon J. Sullivan, Heather C. Allen, Edward W. Martin, Charles L. Hitchcock, E. David Alten, Nicholas E. Long
  • Publication number: 20160143693
    Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.
    Type: Application
    Filed: November 20, 2014
    Publication date: May 26, 2016
    Inventors: Alper Yilmaz, Edward W. Martin, Stephen P. Povoski, Charles L. Hitchcock, Enver Ozer, Ronald Xu
  • Publication number: 20090234225
    Abstract: Exemplary embodiments include systems, methods, and compositions for the intra-operative detection of target tissue. At least one embodiment includes a fluorescence detection instrument that may be used for intra-operative detection of a fluorescent targeting agent, its binding site, and its interaction within cancer tissues. An exemplary embodiment is highly sensitive to the local deposition of fluorescence agents even at a low concentration. In at least one embodiment, the system includes a handheld navigation instrument that is usable to excite, detect, and report the fluorescent deposition of the targeting agent in real-time. In alternative embodiments, the system includes a wearable unit to excite, detect, and visually report the fluorescent deposition of the targeting agent to the user. The wearable unit includes eyewear that allow the user to perform image-guided surgery based on the near real-time fluorescence detection of the fluorescent targeting agent.
    Type: Application
    Filed: January 12, 2009
    Publication date: September 17, 2009
    Applicant: The Ohio State University Research Foundation
    Inventors: Edward W. Martin, Ronald X. Xu, Duxin Sun, Stephen P. Povoski, Joseph Pierre Heremans, Robert Lee, Vish V. Subramaniam, Claudia Turro
  • Patent number: 6418338
    Abstract: A method is provided for immune corrective surgical removal of lymphoid tissues containing shed tumor antigen in an individual. A detector molecule, with binding specificity for shed tumor antigen, is administered to an individual, and detected in the individual is the presence of lymphoid tissue which contains shed tumor antigen, as detected by the signal emitted by the detector molecule bound to shed tumor antigen. The lymphoid tissue, detected as containing shed tumor antigen, may then be surgically removed, thereby removing B cells, shed tumor antigen, and follicular dendritic cells involved in a pro-tumor immune response that are contained in the removed lymphoid tissue.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: July 9, 2002
    Assignee: Phylatron Ltd.
    Inventors: Emilio Barbera-Guillem, Edward W. Martin, Jr.
  • Patent number: 5814295
    Abstract: The present invention is directed to a method for reliably determining lymph nodes enriched in tumor reactive cells, e.g., CD4+tumor-specific lymphocytes. This method includes the steps of administering to a patient an effective amount of a radiolabeled locator which specifically binds a marker produced by or associated with neoplastic tissue. Time is permitted to elapse following the administration for the radiolabeled locator to preferentially concentrate in any neoplastic tissue and for unbound radiolabeled locator to be cleared, so as to increase the ratio of photon emissions from neoplastic tissue to background photon emissions in the patient. After the time has elapsed, the patient is accessed with a radiation detection probe for determining lymph node sites exhibiting accretion of the radiolabeled locator by detecting with the probe elevated levels of radiation at the lymph node sites.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: September 29, 1998
    Assignee: The Ohio State University Research Foundation
    Inventors: Edward W. Martin, Jr., Brian J. Czerniecki, Pierre L. Triozzi, Julian A. Kim
  • Patent number: 5590656
    Abstract: Broadly, the present invention is directed to a method for the detection and differentiation of neoplastic tissue in a patient suspected of having neoplastic tissue. The method includes the administration of a radiolabeled somatostatin congener to the patient and accessing the patient with a radiation detection probe for determining tissue exhibiting elevated levels of radiation, viz., neoplastic tissue. However, before subjecting the patient to such administration, an initial determination preferably is made as to whether the radiolabeled somatostatin congener will bind to the tumor site, i.e., whether somatostatin receptors are associated with the neoplastic tissue. This is conveniently done with a wide variety of endocrine tumors, which release peptides or hormones, referred to as "biochemical markers. " In order to make this determination, initially a biochemical marker-inhibiting dose of unlabeled somatostatin congener is administered to the patient.
    Type: Grant
    Filed: August 31, 1993
    Date of Patent: January 7, 1997
    Assignee: The Ohio State University Research Foundation
    Inventors: Thomas M. O'Dorisio, M. Sue O'Dorisio, Edward W. Martin, Jr., Eugene A. Woltering
  • Patent number: 5482040
    Abstract: Broadly, the present invention is directed to a method for reliably staging adenocarcinomas typified by colorectal cancer in patients who are undergoing surgery therefor. The method includes the administration of a radiolabeled tumor-associated glycoprotein (TAG) antibody (or other equivalent locator) to the cancer patient prior to surgical accession of the patient. Desirably, the present method includes surgical accession with a radiation detection probe for determining tissue exhibiting elevated levels of radiation. The preferred radiolabel is .sup.125 I, which is used to label an antibody specific to a high molecular weight glycoprotein called TAG-72. The preferred antibody is CC49, a murine monoclonal antibody of the IgG.sub.1 subclass. With radiolabeled monoclonal antibody CC49, it preferably is administered to the patient approximately 21 days (.+-.4 days) prior to surgery.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: January 9, 1996
    Assignee: The Ohio State University Research Foundation
    Inventor: Edward W. Martin, Jr.
  • Patent number: 4782840
    Abstract: The present invention is addressed to a method for the improved localization, differentiation, and removal of neoplastic tissue in animals. In particular, one aspect of the present invention involves a surgical procedure wherein an animal suspected of containing neoplastic tissue is surgically accessed and the tissue therein examined visually and by palpation for evidence of neoplastic tissue. The improved methodology commences with the administering to the animal of an effective amount of a labelled antibody specific for neoplastic tissue and labelled with a radioactive isotope exhibiting specific photon emissions of energy levels. Next, and importantly, the surgial procedure is delayed for a time interval following said administering for permitting the labelled antibody to preferentially concentrate in any neoplastic tissue present in the animal so as to increase the ratio of photon emissions from neoplastic tissue to background photon emissions in said animal.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: November 8, 1988
    Assignee: Neoprobe Corporation
    Inventors: Edward W. Martin, Jr., Marlin O. Thurston
  • Patent number: 4355570
    Abstract: A barbecue oven is provided for cooking and smoking food. The oven includes a grease control system for the door of the oven comprising an inset portion and a door grease deflector cooperating to direct grease and moisture deposited on the inner door surface during cooking to the bottom interior surface of the oven. The oven also includes an electrical heating element support and wood tray assembly. An electrical heating element is supported within the assembly and protected from contact with grease or moisture within the oven. The heating element support confines heat generated by the heating element to create an area beneath the top surface of the heating element support having a relatively elevated temperature. This elevated temperature enhances the natural convection within the oven to uniformly heat the cooking area and also causes the wood within the wood tray assembly to smoulder. Multiple apertures in the assembly aid the convection flow for efficient heat transfer to the oven.
    Type: Grant
    Filed: August 5, 1980
    Date of Patent: October 26, 1982
    Assignee: Fred B. Bearden, Jr.
    Inventors: Edward W. Martin, Kenneth R. Meyers, Fred E. Tucker, III
  • Patent number: 4307659
    Abstract: A barbecue oven is provided for cooking and smoking food. The oven includes a grease control system for controlling and containing grease and moisture produced by the food during cooking operations. An air control system is provided which includes passive features for insuring that there is adequate air circulation within the oven during cooking operations. The oven includes an inner oven liner defining a cooking area. An ash pan, an electrical heating element and a wood tray are assembled within the cooking area for cooking and smoking food within the oven. The temperature range within the oven is controlled by a thermostat that includes a temperature sensor mounted on the exterior surface of the oven liner. The oven includes an oven door and at least one wear-resistant latch for securing the door in a closed position.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: December 29, 1981
    Assignee: MTM Corporation
    Inventors: Edward W. Martin, Kenneth R. Meyers, Fred E. Tucker, III