Patents by Inventor Edward W. Petrillo, Jr.

Edward W. Petrillo, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted carbonyl phosphinyl-alkanoyl compounds
    Patent number: 4416833
    Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: November 26, 1982
    Date of Patent: November 22, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
  • Phosphinylalkanoyl amino acids
    Patent number: 4396772
    Abstract: Angiotensin converting enzyme activity is inhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkyl(alkyl);R.sub.2 and R.sub.4 each is independently hydrogen, alkyl, arylalkyl or ##STR2## wherein X is hydrogen, alkyl, or phenyl and Y is hydrogen, alkyl, phenyl or alkoxy, or together X and Y are --(CH.sub.2).sub.2 --, --(CH.sub.2).sub.3 --, --CH.dbd.CH--or ##STR3## R.sub.3 is hydrogen or alkyl; ##STR4## is a residue of an amino acid selected from the group consisting of glycine, alanine, valine, norvaline, leucine, N-methylleucine, norleucine, isoleucine, phenylalanine, tyrosine, serine, threonine, cysteine, methionine, aspartic acid, glutamic acid, arginine, lysine, asparagine, glutamine, histidine, or tryptophane; andn is 0 or 1.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: August 2, 1983
    Assignee: F. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • Phosphinylalkanoyl substituted prolines
    Patent number: 4384123
    Abstract: Esters of phosphinylalkanoyl prolines and phosphinylalkanoyl substituted prolines are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.
    Type: Grant
    Filed: November 30, 1981
    Date of Patent: May 17, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • Substituted carbonyl phosphinyl-alkanoyl compounds
    Patent number: 4381297
    Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester are disclosed as useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: May 4, 1981
    Date of Patent: April 26, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
  • Amino and substituted amino phosphinyl-alkanoyl compounds
    Patent number: 4374131
    Abstract: Compounds of the formula ##STR1## wherein X is an imino acid or ester and R.sub.1 is hydrogen, ##STR2## are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: February 15, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • Phosphinylalkanoyl substituted prolines
    Patent number: 4337201
    Abstract: Esters of phosphinylalkanoyl prolines and phosphinylalkanoyl substituted prolines are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.
    Type: Grant
    Filed: December 4, 1980
    Date of Patent: June 29, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • 4-Azido-1-mercaptoacyl pipecolic acid
    Patent number: 4308388
    Abstract: 1-Mercaptoacyl proline or pipecolic acid having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: December 29, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Frank L. Weisenborn
  • Hydroxamic acid derivatives of mercaptoacyl amino acids
    Patent number: 4308392
    Abstract: Hydroxamic acid derivatives of certain mercaptoacyl amino acids inhibit the conversion of angiotensin I to angiotensin II in mammals and are useful for the treatment of hypertension.
    Type: Grant
    Filed: November 20, 1980
    Date of Patent: December 29, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Miguel A. Ondetti
  • 4-Azido-1-mercaptoacyl proline
    Patent number: 4296033
    Abstract: 1-Mercaptoacyl proline having an azido group in the 4-position inhibits the conversion of angiotensin I to angiotensin II in mammals and is useful for the treatment of hypertension.
    Type: Grant
    Filed: July 23, 1980
    Date of Patent: October 20, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Frank L. Weisenborn
  • Hydroxamic acid derivatives of mercaptoacyl amino acids
    Patent number: 4284561
    Abstract: Hydroxamic acid derivatives of certain mercaptoacyl amino acids inhibit the conversion of angiotensin I to angiotensin II in mammals and are useful for the treatment of hypertension.
    Type: Grant
    Filed: December 3, 1979
    Date of Patent: August 18, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Edward W. Petrillo, Jr., Miguel A. Ondetti
  • Mercaptoacylpyrrolidine phosphonic acids and related compounds
    Patent number: 4186268
    Abstract: New mercaptoacylpyrrolidine- and mercaptoacylpiperidine phosphonic acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: January 29, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.
  • Phosphinylalkanoyl prolines
    Patent number: 4168267
    Abstract: New phosphinylalkanoyl prolines which have the general formula ##STR1## wherein R.sub.1 is lower alkyl, phenyl or phenyl-lower alkyl;R.sub.2 is hydrogen, phenyl-lower alkyl or a metal ion;R.sub.3 is hydrogen or lower alkyl;R.sub.4 is hydrogen, lower alkyl, phenyl-lower alkyl or a metal ion; andN is 0 or 1,Are useful as hypotensive agents.
    Type: Grant
    Filed: October 23, 1978
    Date of Patent: September 18, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Edward W. Petrillo, Jr.