Abstract: An exercise system includes a user input arrangement; a rotatable member that rotates in response to an input force applied by a user on the user input arrangement; a power sensing arrangement that senses power applied to the rotatable member due to the input force applied by the user; and a variable resistance arrangement interconnected with the power sensing arrangement and with the user input arrangement. The resistance arrangement applies resistance to rotation of the rotatable member, and is variable in response to the power sensing arrangement to vary the resistance applied to the rotatable member. The variable resistance arrangement may be a brake that interacts with the rotatable member to resist rotation of the rotatable member, and to thereby resist the input force applied by the user. The variable resistance arrangement includes a controller for controlling the brake in response to the power sensing arrangement.

Abstract: Described herein is a GPS pet containment system is that generally self contained within a collar. However, the collar includes a battery power source, a microcontroller powered by the battery power source, a global positioning system (GPS) interfaced to the microcontroller and an accelerometer interfaced to the microcontroller. The GPS operates to provide collar location information on a periodic basis while the accelerometer provides collar dead reckoning location information on a substantially continuous basis. The dead reckoning location information is acquired by integrating the acceleration value provided by the accelerometer over sub-second time intervals.

Abstract: A performance data storage device is provided that enables an individual performing an exercise session to record and transmit data concerning the exercise session in a real time manner using a mechanical interface or in a wireless manner. The device is capable of storing performance data for a number of exercise sessions and downloading the data to a separate computing device to analyze the data. Additionally, the device stores this data in conjunction with additional user information, such as a user identification code and exercise machine set-up parameters, in order to enable the device to set up an exercise machine for use by an individual prior to beginning any subsequent exercise session. The device can communicate with a computer using a USB standard protocol yet be able to communicate with a USB peripheral device, i.e., an exercise machine console, without the need for a USB host device.

Abstract: An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an affinity ligand other than the dye attached to a fraction of the polymeric support for the capture of a molecule. Also provided is a method for the isolation of a biomolecule from an aqueous solution. The method comprises combining the aqueous solution with an affinity matrix comprising a polymeric support and separating the affinity matrix from the aqueous solution. A dye is attached to a fraction of the polymeric support which enables optical detection and monitoring of the affinity matrix and, accordingly, reduces the likelihood of the loss of affinity matrix during the separation step. In addition, an affinity ligand other than the dye is also attached to a fraction of the polymeric support for the capture of the biomolecule.

Abstract: Processes for the detection and purification of peptides and proteins comprising a metal ion-affinity peptide having a high affinity for coordinated metals and also being highly antigenic are described. Antibodies for use in the processes are also described.

Abstract: An exercise system includes a user input arrangement; a rotatable member that rotates in response to an input force applied by a user on the user input arrangement; a power sensing arrangement that senses power applied to the rotatable member due to the input force applied by the user; and a variable resistance arrangement interconnected with the power sensing arrangement and with the user input arrangement. The resistance arrangement applies resistance to rotation of the rotatable member, and is variable in response to the power sensing arrangement to vary the resistance applied to the rotatable member. The variable resistance arrangement may be a brake that interacts with the rotatable member to resist rotation of the rotatable member, and to thereby resist the input force applied by the user. The variable resistance arrangement includes a controller for controlling the brake in response to the power sensing arrangement.

Abstract: An apparatus includes a frame having first and second spaced apart areas. A movable member is mounted adjacent the first area, and a sensor senses an operating characteristic of the movable member. A data receiving device is located in the vicinity of the second area of the frame. A first data signal transmission component is interconnected with the sensor, and receives data signals from the sensor and inputs the data signals to the frame. A second data signal transmission component is interconnected with the data receiving device, and receives data signals from the frame and transmits the data signals to the data receiving device. The data signals are transmitted though the frame from the first data signal transmission component to the second data signal transmission component. The apparatus may be a bicycle, and the movable member may be a bicycle wheel or pedal assembly.

Abstract: A wireless, passive wheel-speed and detection system is provided for measuring the rate of rotation of a rotating component of a bicycle. The detection system includes a sensor arrangement having a first portion mounted on the bicycle and a second portion mounted on the rotating component. The sensor arrangement generates an input signal representative of a revolution of the rotating component. A transmitter circuit is operatively connected to the sensor arrangement for converting the input signal to a radio frequency signal and for transmitting the radio frequency signal. A controller receives the radio frequency signal and translates the radio frequency signal to a value indicative of a rate of rotation of the rotating component.

Abstract: An enclosed operating characteristic sensing system for a bicycle includes a sensing arrangement for sensing one or more operating characteristics of the bicycle, and an emitter responsive to the sensing arrangement for emitting a signal from a first location on the bicycle to a receiver located in a second location on the bicycle. The emitter is contained within an interior defined by a component of the bicycle at the first location on the bicycle, and the bicycle component is constructed so as to enable the emitted signal to pass through the component for transmission to the receiver. The sensing arrangement may be configured to sense power applied by an operator of the bicycle to impart movement to the bicycle.

Abstract: An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an affinity ligand other than the dye attached to a fraction of the polymeric support for the capture of a molecule. Also provided is a method for the isolation of a biomolecule from an aqueous solution. The method comprises combining the aqueous solution with an affinity matrix comprising a polymeric support and separating the affinity matrix from the aqueous solution. A dye is attached to a fraction of the polymeric support which enables optical detection and monitoring of the affinity matrix and, accordingly, reduces the likelihood of the loss of affinity matrix during the separation step. In addition, an affinity ligand other than the dye is also attached to a fraction of the polymeric support for the capture of the biomolecule.