Abstract: Disclosed are techniques for two-way synchronization of infrastructure-as-code templates and instances, including a method comprising detecting changes to a run-time state of a system and, in response to detecting a change, triggering an update of a current run-time state model. The method may further comprise, in response to updating the run-time state model, comparing the updated model to a current model using a template in a local repository instantiated as the current model. The method may further comprise, in response to the comparison determining a structural difference between the updated model and the current model, merging the updated model and the current model into a new model; and updating a local clone of a repository of the template with the new model. The method may further comprise, in response to the comparison determining no structural difference between the updated model and the current model, pushing changes to a remote repository.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The present disclosure relates to multifunctional verification molecules, including molecules according to formula (I): G-L-(B)K-Q-U, wherein G, L, B, K, Q, and U are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional verification molecules to remove defective multifunctional molecules and to quantify synthetic yield.

Abstract: Described herein are systems and methods for baggage or parcel handling. The system includes an automated bag unloading cell, a container roller deck positioned in the automated unloading cell. The container roller deck includes a roller deck base and a deck frame. The deck frame can selectively support and transfer a container housing a bag or parcel. The deck frame can selectively rotate about a deck frame axis of rotation relative to the roller deck base. The deck frame is operable to selectively release the bag or parcel from the container. The container roller deck can also include an index table in communication with the deck frame. The index table can be operable to receive the bag or parcel released from the container. The index table can include at least one index table conveyor operable to selectively advance the bag or parcel from the index table to a first transfer device.

Abstract: A bag handling system for a mass transit environment is disclosed. The bag handling system includes a first set of autonomous automated guided vehicles and a second set of autonomous automated guided vehicles. The first and second sets of autonomous automated guided vehicles are configured to transport bags through one or more bag processing areas.

Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y—H1)O-G-(H2-[L2-E-(B2)K]W)P, ??(I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

Abstract: The present disclosure provides methods and systems for determining a target-activity of at least one resolved oligonucleotide encoded molecule. In an embodiment, a method includes providing a separation medium, wherein the separation medium contains at least one target molecule; and various methods of separating a mixture of at least two oligonucleotide encoded molecules by electrophoresis based on different target-activities of the oligonucleotide encoded molecules for a target molecule. Benefits of the methods disclosed herein can include, without limitation, collecting and calculating qualitative and quantitative data for the target-activity of an encoded portion of the oligonucleotide encoded molecule for a target molecule.

Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y-H1)O-G-(H2-[L2-E-(B2)K]W)P, ??(I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

Abstract: Described herein are systems and methods for baggage or parcel handling. The system includes an automated bag unloading cell, a container roller deck positioned in the automated unloading cell. The container roller deck includes a roller deck base and a deck frame. The deck frame can selectively support and transfer a container housing a bag or parcel. The deck frame can selectively rotate about a deck frame axis of rotation relative to the roller deck base. The deck frame is operable to selectively release the bag or parcel from the container. The container roller deck can also include an index table in communication with the deck frame. The index table can be operable to receive the bag or parcel released from the container. The index table can include at least one index table conveyor operable to selectively advance the bag or parcel from the index table to a first transfer device.

Abstract: A bag handling system for a mass transit environment is disclosed. The bag handling system includes a first set of autonomous automated guided vehicles and a second set of autonomous automated guided vehicles. The first and second sets of autonomous automated guided vehicles are configured to transport bags through one or more bag processing areas.

Abstract: The present disclosure relates to multifunctional verification molecules, including molecules according to formula (I): G-L-(B)K-Q-U, wherein G, L, B, K, Q, and U are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional verification molecules to remove defective multifunctional molecules and to quantify synthetic yield.

Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I-A) [(B1)M-L1]O-G, and (I) [(B1)M-L1]O-G-[(L2-(B2)K]P wherein B1, M, L1, O, G, L2, B2, K, and P are defined herein, wherein each positional building block B1 is identified by from 1 to 5 coding regions in G, and from about 10% to 100% of the positional building blocks B1 at position M and/or B2 at position K, based on a total number of positional building blocks, are identified by a combination of from 2 to 5 independent coding regions. Methods of making such multifunctional molecules, and methods of serially enriching an oligonucleotide encoded library, are also disclosed. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

Abstract: The present disclosure relates to multifunctional molecules, including molecules according to formula (I): ([(B1)M-D-L1]Y-H1)O-G-(H2-[L2-E-(B2)K]W)P, ??(I) wherein G, H1, H2, D, E, B1, B2, M, K, L1, L2, O, P, Y, and W are defined herein. The present disclosure also relates to methods of preparing and using such multifunctional molecules to identify encoded molecules capable of binding target molecules.

Abstract: Disclosed herein are methods and compositions for purifying proteins from crude solutions.

Abstract: Disclosed herein are methods and compositions for purifying proteins from crude solutions.

Abstract: Disclosed herein are methods and compositions for purifying proteins from crude solutions.

Abstract: This disclosure provides materials and methods for synthesis and use of pH switchable ligands.

Abstract: Provided herein are methods of synthesis of a compound which includes a functional moiety operatively linked to a tagging oligonucleotide, libraries thereof and methods of using the compound and libraries thereof to identify compounds which bind to a target.

Abstract: Disclosed herein are methods and compositions for purifying proteins from crude solutions.

Abstract: Transglutaminase inhibitors and methods of use thereof are provided.