Abstract: The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: The present invention includes methods of preparing a composite structure comprising: placing a first ply of a fibrous material with a curable material on a layup tool; adding one or more additional plies on the first ply, wherein each of the one or more additional plies has a perimeter that is different in size around the perimeter than a previous ply to form a taper; and curing the composite structure, wherein the curable material is selected to minimize, limit, control, or eliminate the outflow of the curable material along the perimeter of the composite structure during the curing step.

Abstract: The present invention includes methods of preparing a composite structure comprising: placing a first ply of a fibrous material with a curable material on a layup tool; adding one or more additional plies on the first ply, wherein each of the one or more additional plies has a perimeter that is different in size around the perimeter than a previous ply to form a taper; and curing the composite structure, wherein the curable material is selected to minimize, limit, control, or eliminate the outflow of the curable material along the perimeter of the composite structure during the curing step.

Abstract: A dynamic video communications system provides real time provisioning of a video communication session in a domain video network between a set of user devices. The real time provisioning is implemented by receiving an identifier of a video communication session from a user device, where the identifier includes a domain and a name, determining an authentication principle associated with the user device, where the authentication principle includes a domain of the user, checking whether the domain of the user matches a domain of the video communication session, and joining the user device with the video communication session.

Abstract: A method and apparatus are provided that are implemented at a conference apparatus to provide an optimization of video conferencing resource utilization. The method receives a plurality of resource constraints where each resource constraint is from a conference device in a plurality of conference devices, wherein at least a first resource constraint of a first conference device contains an indication of a video processing capability of the first conference device. The method further computes a conference solution matrix for the plurality of conference devices based on the plurality of resource constraints, wherein the conference solution matrix contains a solution entry for each of the plurality of conference devices, and wherein for the first conference device, a corresponding first solution entry indicates a video processing solution selection for the first conference device. Solution entries are then sent to corresponding conference devices of the plurality of conference devices.

Abstract: A dynamic video communications system provides real time provisioning of a video communication session in a domain video network between a set of user devices. The real time provisioning is implemented by receiving an identifier of a video communication session from a user device, where the identifier includes a domain and a name, determining an authentication principle associated with the user device, where the authentication principle includes a domain of the user, checking whether the domain of the user matches a domain of the video communication session, and joining the user device with the video communication session.

Abstract: A method of proximity-based conference session transfer is disclosed. The method is implemented at a conference device and it starts with the conference device generating a conference session code based on an encrypted conference session message received from a conference server. The conference device communicates the conference session code to an area in proximity to the conference device, where a user device in the area in proximity to the conference device receives the conference session code and requests the conference server to coordinate the conference device to assume a conference session of the user device. The conference device then receives a message from the conference server requesting the conference device to assume the conference session of the user device, and it assumes the conference session of the user device by performing conference functions according to input from the user device.

Abstract: N-(Substituted-aryl-hydroxyalkylidene)-cycloalkyl carboxamide compositions are disclosed that target molecular elements on sensory nerves. These compounds, preferably administered topically, inhibit the perception of itch and pain and have prolonged duration of action.

Abstract: This invention provides members of the corticiotropin-releasing hormone superfamily and peptide analogs thereof wherein the 38th amino acid from the N-terminus is D-Nle, i.e. [D-Nle38]-CRH peptide. The peptide analogs can be used to treat proliferative disorders of the skin such as melanoma.

Abstract: N-(Substituted-aryl-hydroxyalkylidene)-cycloalkyl carboxamide compositions are disclosed that target molecular elements on sensory nerves. These compounds, preferably administered topically, inhibit the perception of itch and pain and have prolonged duration of action.

Abstract: One embodiment of the invention is a composition that comprises a radioactive [18F], [76Br]-, [77Br]-, [211At]-, [123I], [125I], or [131I]-N-radioistope-labeled-aryl-alkyl-alkylcarboxamide molecule. The composition binds to the transient receptor potential-M8 (TRP-M8) receptor of cells. The TRP-M8 receptor is selectively expressed in sensory neurons and in malignant tissues such as prostate cancer cells. The [18F], [76Br]-, [77Br]-, [211At]-, [123I], [125I], or [131I]-N-radioistope-labeled-aryl-alkyl-alkylcarboxamide ligand may be used for radioreceptor binding studies, for diagnostic studies, and for radiotherapy of cancerous tissues. Affinity of the N-radioistope-labeled-aryl-alkyl-alkylcarboxamide ligand for the TRP-M8 receptor confers selectivity and specificity in delivering lethal radiation to the diseased cells.

Abstract: An apparatus, system and method of concurrent high-performance transport of variable-length messages are provided. The invention overcomes the problem of transporting a message comprising more bits than the maximum allowable group transmission on a network, by fragmenting the message into a plurality of data packets and transmitting the data packets concurrently. In addition, the present invention overcomes the problem of inefficient storage space allocation for reconstruction of the message from the data packets by sending the size of the message with each data packet.

Abstract: N-(Substituted-aryl-alkyl)-cycloalkyl carboxamide compositions are disclosed that target molecular elements on sensory nerves and on secretory epithelia. Modulation of ion fluxes in neurons and epithelia inhibits the perception of itch, pain, discomfort from the skin. By acting on these targets, preferred embodiment compositions are useful for skin and sensory disorders, and, in the case of secretory epithelia, to retard cellular proliferation. These compounds are formulated as a topical or oral preparation with prolonged duration of action.

Abstract: Novel peripheral antinociceptive compounds are disclosed having a pharmacophore unit that target small-diameter nerve fibers that transmit signals of pain and discomfort from the soma and viscera. By acting on this target, the pharmacophore unit obtunds pain and diminishes hyper-reflexia from organs such as the skin, the respiratory tract, the corpus, the lower urinary tract, and the bowel. The pharmacophore unit is coupled to substituents that facilitate delivery of the pharmacophore to its target.

Abstract: This invention relates to peptide analogs of corticotropin-releasing hormone. Particularly, the invention provides methods for treating proliferative disorders by administering peptide analogs wherein the 38th amino acid from the N-terminus is D-Nle, i.e. [D-Nle38]-CRH peptide.

Abstract: One embodiment of the invention is a composition that comprises a radioactive [18F], [123I], [125I], or [131I]—N-radiohaloaryl-alkylcarboxamide molecule. The composition binds to the transient receptor potential-M8 (TRP-M8) receptor of cells. The TRP-M8 receptor is selectively expressed in sensory neurons and in malignant tissues such as prostate cancer cells. The [18F], [123I], [125I], or [131I]—N-radiohaloaryl-alkylcarboxamide ligand may be used for radioreceptor binding studies, for diagnostic studies, and for radiotherapy of cancerous tissues. Affinity of the [125I] or [131I]—N-radiohaloaryl-alkylcarboxamide ligand for the TRP-M8 receptor confers selectivity and specificity in delivering lethal radiation to the diseased cells.

Abstract: Eye discomfort is reduced by administering drops of an inventive composition containing a trialkyl phosphine oxide in an ophthalmic solution. The preferred method of administration is to drip the solution onto the medial canthus of the closed eye and to keep the eye closed until at least one minute after instillation. The preferred trialkyl phosphine oxide is selected for potency, long duration of action, and the absence of irritancy. A hydrocarbon polyol or a similar demulcent may be added to the composition in order to further reduce irritancy. The concentration of the trialkyl phosphine oxide in the ophthalmic solution is preferably in an amount of at least about 0.001 wt. % to about 0.5% (10 ?g/ml to 5 mg/ml) of the composition.

Abstract: An air purifier is constructed to include a conduit housing a high voltage circuit board and a high voltage generator in a rear section thereof and at least one high voltage electrode and a number of ground electrodes in a front section thereof, the high voltage electrode and ground electrodes functioning as an ionizer as well as an electrostatic precipitator, trapping and removing contaminants from the air when receiving a high voltage output from the high voltage generator, so that air flowing by the high voltage electrode gets ionized and, floating contaminant particles are then combined with air ions, which are drawn to the ground electrodes and get trapped and neutralized by the ground electrodes.

Abstract: The present invention discloses a dynamically-adaptive connector-bridge for receiving data frames from a source-network and transmitting the data frame to a destination-network including a plurality of host-computers for receiving the data frames. The connector-bridge includes a data-frame converter for converting the data frames into corresponding destination-network-data-frames suitable for transmission in the destination network. The bridge-connector further includes a dynamic-dispatching means for receiving the destination-network-data-frames for determining a frame-type, a byte-length, and a set of destination-host-computers on the destination-network, and the dynamic-dispatching means employing the frame type, the byte-length, the set of destination-host computers, and a current-data-transmission-state of the destination-network to dynamically prioritize the destination-network-data-frames for dispatching each of the destination-network-data-frames to the set of destination-host-computers.