Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A system for outputting an action signal to a controlled system is provided. The system includes a memory storing individuals to be deployed to a production environment as an actor, wherein each of the individuals has a rule associated therewith for asserting an action, and the actor includes one or more individuals, is associated with the controlled system and is configured to transmit an intermediate action signal for asserting the action. The system includes a management server configured to receive the intermediate action signal, select, from a set of available operations, a selected operation to perform with respect to the intermediate action signal, and the set of available operations including allowance and a blocking of the intermediate action signal. Further, in response to the selected operation being the allowance, transmitting the intermediate action signal, and in response to the selected operation being the blocking, blocking the intermediate action signal.

Abstract: A system for outputting an action signal to a controlled system is provided. The system includes a memory storing individuals to be deployed to a production environment as an actor, wherein each of the individuals has a rule associated therewith for asserting an action, and the actor includes one or more individuals, is associated with the controlled system and is configured to transmit an intermediate action signal for asserting the action. The system includes a management server configured to receive the intermediate action signal, select, from a set of available operations, a selected operation to perform with respect to the intermediate action signal, and the set of available operations including allowance and a blocking of the intermediate action signal. Further, in response to the selected operation being the allowance, transmitting the intermediate action signal, and in response to the selected operation being the blocking, blocking the intermediate action signal.

Abstract: A device, system, and method are directed towards facilitating monetization of mobile devices. A click action server determines click actions that are to be sent to a client device based on one or more factors. The click actions are sent to the client device as links. An action handler receives requests indicating a selected action, and facilitates the performance of the action.

Abstract: A system for outputting an action signal to a controlled system is provided. The system includes a memory storing individuals to be deployed to a production environment as an actor, wherein each of the individuals has a rule associated therewith for asserting an action, and the actor includes one or more individuals, is associated with the controlled system and is configured to transmit an intermediate action signal for asserting the action. The system includes a management server configured to receive the intermediate action signal, select, from a set of available operations, a selected operation to perform with respect to the intermediate action signal, and the set of available operations including allowance and a blocking of the intermediate action signal. Further, in response to the selected operation being the allowance, transmitting the intermediate action signal, and in response to the selected operation being the blocking, blocking the intermediate action signal.

Abstract: A device, system, and method are directed towards facilitating monetization of mobile devices. A click action server determines click actions that are to be sent to a client device based on one or more factors. The click actions are sent to the client device as links. An action handler receives requests indicating a selected action, and facilitates the performance of the action.

Abstract: A device, system, and method are directed towards facilitating monetization of mobile devices. A click action server determines click actions that are to be sent to a client device based on one or more factors. The click actions are sent to the client device as links. An action handler receives requests indicating a selected action, and facilitates the performance of the action.

Abstract: A speech recognition system provides a subword decoder and a dictionary lookup to process a spoken input. In a first stage of processing, the subword decoder decodes the speech input based on subword units or particles and identifies hypothesized subword sequences using a particle dictionary and particle language model, but independently of a word dictionary or word vocabulary. Further stages of processing involve a particle to word graph expander and a word decoder. The particle to word graph expander expands the subword representation produced by the subword decoder into a word graph of word candidates using a word dictionary. The word decoder uses the word dictionary and a word language model to determine a best sequence of word candidates from the word graph that is most likely to match the words of the spoken input.

Abstract: A method and apparatus is provided which employs phase or amplitude modulated electromagnetic probing waves (in optical or microwave frequency ranges or both) emitted toward a vibrating object. The optical and/or microwave probing signals remotely irradiate an object of interest. The object reflects and/or scatters the probing wave toward to a receiver. The reflected/scattered modulated signal is received with a remote sensor (receiver). Vibration causes additional phase modulation to the probing wave. At the receiving end, the signal is demodulated to extract and analyze the vibration waveform. The present invention can be utilized for nondestructive testing, monitoring of technological processes, structural integrity, noise and vibration control, mine detection, etc.

Abstract: A collector boost circuit is disclosed for providing a first voltage in a first mode of operation to a power amplifier, and a second voltage in a second mode of operation to the power amplifier. The collector boost circuit uses a switch and an indicator signal for triggering the switch between the first and the second mode of operation. The second voltage is a boosted voltage greater than the first voltage and is provided during peak excursions through a boost capacitor.

Abstract: A dual output voltage regulator circuit is disclosed. The output voltage regulator has a first FET and a second FET. A current source responsive to the regulated output voltage provides a current drive to the gate of the first FET in a first mode of operation and to the gate of the second FET in a second mode of operation. Further, the circuit employs switches for switchably selecting between the first mode of operation and the second mode of operation.

Abstract: A method and apparatus (10) is provided which employs phase or amplitude modulated electromagnetic probing waves (20) (in optical or microwave frequency ranges or both) emitted toward a vibrating object (8). The optical and/or microwave probing signals (20) remotely irradiate an object (8) of interest. The object (8) reflects and/or scatters the probing wave (20) toward a receiver (22). The reflected/scattered modulated signal (24) is received with a remote sensor (receiver) (22). Vibration causes additional phase modulation to the probing wave (20). At the receiving end, the signal is demodulated to extract and analyze the vibration waveform (26,28). The present invention can be utilized for nondestructive testing, monitoring of technological processes, structural integrity, noise and vibration control, mine detection, etc.

Abstract: A low dropout (LDO) PFET regulator circuit is disclosed for operating in two modes of operation. For higher supply voltage potentials the LDO PFET regulator circuit operates normally, as supply voltage potential drops, the LDO PFET regulator operates in a second mode of operation where a decision circuit determines whether to supply a first boost current thereto in order to compensate for the reduced transimpedance of the first PFET.

Abstract: A novel low voltage wide ratio current mirror circuit is disclosed. The circuit comprises an n times current mirror having an input port for receiving an input current and an m times current mirror coupled in series to the n times current mirror for resulting in an output current of (n times m the input current) being provided to a load. The novel circuit provides significant improvements in precision in output current for used with a low voltage PA without incurring an overhead of quiescent current. A novel low voltage wide ratio current mirror circuit in accordance with a second embodiment of the invention includes a voltage swing reduction circuit in order to provide increased stability thereto. In additional embodiments of the invention, the load is a differential amplification stage for providing differential amplification to differential RF input signals received at first and second RF input ports thereof.

Abstract: A power amplifier circuit is disclosed having a first amplification stage and a second amplification stage. The first amplification stage is biased using a controllable current source that provides a variable bias current thereto. A control circuit is provided for controlling the variable bias current in dependence upon the supply voltage and temperature of the power amplifier circuit. The control signal varies the variable bias current in dependence upon the supply voltage varying between first and second potential, where each potential supplies sufficient potential for operation of the power amplifier circuit.

Abstract: Power supply noise affects the performance of many amplifier circuits. Power supply noise rejection circuits are typically used in conjunction with amplifier circuits to reduce the effects of the noise. Unfortunately, the main issue with a transimpedance amplifier (TIA) is that it has a single input port and a single output port, and the output ports are often required to be of a differential type in order to interface with a differential input post amplifier circuit. As a result, the conversion from single input port operation to a dual input port configuration for differential operation is often the cause of poor power supply noise rejection. A circuit is thus provided that overcomes the limitations in the prior art by providing a differential TIA for use with a filter circuit and differential amplifier that overcomes the limitations of the prior art.

Abstract: An optical receiver arrangement comprises a phase locked loop incorporating a voltage controlled oscillator whereby the loop can be matched in frequency to a received signal frequency. A frequency detector associated with the loop produces an output comprising first or second pulses indicative of whether the loop frequency is above or below the received signal frequency. A control circuit determines a time averaged measure of difference between the loop frequency and the received signal frequency, and issues a loss of lock alarm if this averaged difference exceeds a predetermined value.

Abstract: A speech recognition system provides a subword decoder and a dictionary lookup to process a spoken input. In a first stage of processing, the subword decoder decodes the speech input based on subword units or particles and identifies hypothesized subword sequences using a particle dictionary and particle language model, but independently of a word dictionary or word vocabulary. Further stages of processing involve a particle to word graph expander and a word decoder. The particle to word graph expander expands the subword representation produced by the subword decoder into a word graph of word candidates using a word dictionary. The word decoder uses the word dictionary and a word language model to determine a best sequence of word candidates from the word graph that is most likely to match the words of the spoken input.

Abstract: A method and apparatus for conducting laser absorption spectroscopy uses a frequency tunable laser aligned to pass a laser beam through a sample volume and to an optical detector. A two-step modulation is used to generate frequency components that may be used to both lock the tunable laser to the absorbance signal, and generate an output signal proportional to the absorbance signal. The method includes frequency modulating the tunable laser at a first frequency while further modulating the tunable laser with a triangular waveform having a second frequency, and generating a feedback control signal based upon an antisymmetrical signal demodulated from the optical detector using a first predetermined harmonic of the second frequency. The tunable laser is locked to the absorbance signal with the feedback control signal. An output signal proportional to the absorbance signal is generated using a symmetrical signal demodulated using a second predetermined harmonic of the second or triangular waveform frequency.

Abstract: A method and apparatus using a frequency tunable laser to generate a beam which passes through a sample cell and onto an optical detector wherein the tunable laser is modulated at a predetermined frequency which has the undesired effect of producing a periodic interference fringe near an absorption induced signal. An additional level of modulation is applied to the laser beam by a triangular waveform having a predetermined peak-to-peak amplitude and frequency. The triangular waveform peak-to-peak amplitude produces a frequency swing of the laser beam so as to generate from the periodic interference fringe, a signal having reduced components near the absorption induced signal. The signal at the optical detector is demodulated by a lock-in amplifier tuned to a predetermined harmonic of the frequency of the triangular waveform.