Abstract: A wireless supernetwork (WiSNET), or a superintegrated network, allows multiple network technologies to plug and play into one open wired and wireless network, particularly serving dense user environments. WiSNET allows the redirection of independently deployed technologies and provides improved network efficiency, affordability, and user convenience. In embodiments, WiSNET integrates input data from two or more disparate service providers. The WiSNET includes a service delivery system, a data aggregation system that provides aggregated input data, and a local delivery system that transmit the aggregated input data to multiple categories of user via a superintegrated access platform. A superintegrated management system enables assignment of a network slice and/or a service slice to each of a plurality of user profiles.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media that utilize context-aware sensors and multi-dimensional gesture inputs across a digital image to generate enhanced digital images. In particular, the disclosed systems can provide a dynamic sensor over a digital image within a digital enhancement user interface (e.g., a user interface without visual elements for modifying parameter values). In response to selection of a sensor location, the disclosed systems can determine one or more digital image features at the sensor location. Based on these features, the disclosed systems can select and map parameters to movement directions. Moreover, the disclosed systems can identify a user input gesture comprising movements in one or more directions across the digital image. Based on the movements and the one or more features at the sensor location, the disclosed systems can modify parameter values and generate an enhanced digital image.

Abstract: A wearable device for monitoring physical activity of a user, the wearable device being reversibly attachable to a chest strap and an arm strap. The wearable device comprises an ECG sensor arranged to collect ECG measurements of the user only when the wearable device is attached to the user's chest by the chest strap, and a PPG sensor arranged to collect PPG measurements of the user when the wearable device is attached to the user's arm or wrist by the arm strap. The wearable device also comprises control circuitry arranged to switch the wearable device between an ECG only mode and a PPG only mode. In the ECG only mode, the control circuitry is configured to control the ECG sensor to collect ECG measurements but prevent the PPG sensor from initiating PPG measurements. In the PPG only mode, the control circuitry is configured to control the PPG sensor to initiate PPG measurements but prevent the ECG sensor from collecting ECG measurements.

Abstract: A method, system and computer program for predicting a VO2max measurement for a subject, the method comprising: collecting a heart rate recovery value, measured over a first period starting at the end of a fitness test exercise completed by the subject, wherein the fitness test exercise comprises a plurality of phases, each phase having a predetermined duration and each phase being associated with a respective heart rate band, and during each phase, the subject adjusts their effort to maintain their heart rate in the respective heart rate band, and calculating a predicted VO2max measurement using the heart rate recovery value.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with or pharmaceutically acceptable salts thereof wherein R, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof.

Abstract: Methods for identifying optimized antigenic pathogen polypeptides capable of inducing a broadly neutralizing immune response, and associated T-cell responses, to a pathogen are described, as well as nucleic acid sequences encoding such polypeptides. Methods for determining whether a broadly neutralizing immune response is induced in a subject following immunization with an optimized antigenic pathogen polypeptide, or a nucleic acid encoding the optimized pathogen polypeptide, are also described. Nucleic acid molecules, polypeptides, vectors, cells, fusion proteins, pharmaceutical compositions, and their use as vaccines against pathogens, especially against emerging or re-emerging pathogens (particularly RNA viruses), are also described.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media that utilize context-aware sensors and multi-dimensional gesture inputs across a digital image to generate enhanced digital images. In particular, the disclosed systems can provide a dynamic sensor over a digital image within a digital enhancement user interface (e.g., a user interface without visual elements for modifying parameter values). In response to selection of a sensor location, the disclosed systems can determine one or more digital image features at the sensor location. Based on these features, the disclosed systems can select and map parameters to movement directions. Moreover, the disclosed systems can identify a user input gesture comprising movements in one or more directions across the digital image. Based on the movements and the one or more features at the sensor location, the disclosed systems can modify parameter values and generate an enhanced digital image.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media that utilize context-aware sensors and multi-dimensional gesture inputs across a digital image to generate enhanced digital images. In particular, the disclosed systems can provide a dynamic sensor over a digital image within a digital enhancement user interface (e.g., a user interface without visual elements for modifying parameter values). In response to selection of a sensor location, the disclosed systems can determine one or more digital image features at the sensor location. Based on these features, the disclosed systems can select and map parameters to movement directions. Moreover, the disclosed systems can identify a user input gesture comprising movements in one or more directions across the digital image. Based on the movements and the one or more features at the sensor location, the disclosed systems can modify parameter values and generate an enhanced digital image.

Abstract: The present invention is directed to a method of increasing the brightness of non-wood fibers and nonwoven fabric fabrics produced by the method. In one aspect, the method includes forming a mixture of non-wood fibers and exposing the mixture to a brightening agent to produce brightened fibers. The brightening agent is oxygen gas, peracetic acid, a peroxide compound, or a combination thereof. The brightened fibers have a brightness greater than the fibers of the mixture before exposure as measured by MacBeth UV-C standard.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media that utilize context-aware sensors and multi-dimensional gesture inputs across a digital image to generate enhanced digital images. In particular, the disclosed systems can provide a dynamic sensor over a digital image within a digital enhancement user interface (e.g., a user interface without visual elements for modifying parameter values). In response to selection of a sensor location, the disclosed systems can determine one or more digital image features at the sensor location. Based on these features, the disclosed systems can select and map parameters to movement directions. Moreover, the disclosed systems can identify a user input gesture comprising movements in one or more directions across the digital image. Based on the movements and the one or more features at the sensor location, the disclosed systems can modify parameter values and generate an enhanced digital image.

Abstract: The presently disclosed subject matter relates to a multilayer nonwoven material. More particularly, the presently disclosed subject matter relates to multilayered structures including, but not limited to, two, three, or four layers to form the nonwoven material. The multilayered structure can include a first layer comprising continuous filaments and a second layer comprising bonded fibers. The continuous filaments can be synthetic filaments. The fibers can be cellulosic fibers, noncellulosic fibers, or combinations thereof. Certain layers can also contain a binder material.

Abstract: A composite part, such as a stiffener is formed in place. A composite charge is placed on a tool spanning a mold cavity, with the centerline of the charge offset from the centerline of the mold cavity. Opposite sides of the charge are held against the tool as the charge is formed into the mold cavity. One side of the charge is held against movement on the tool while the other side of the charge is allowed to slip over the tool toward the mold cavity.

Abstract: Nonwoven textile fabrics in accordance with the present invention are formed primarily of individualized bast fibers substantially free of pectin having a mean length less than 6 millimeters. The nonwoven fabric can include staple fibers and/or pulp fibers. Individualized bast fibers include fibers derived from the flax and hemp plants. The nonwoven textile fabric is formed into a web while in a dry state and subsequently bonded to produce a nonwoven fabric.

Abstract: Nonwoven textile fabrics in accordance with the present invention are formed primarily of individualized bast fibers substantially free of pectin. The nonwoven fabric can include staple fibers to a lesser extent than the individualized bast fibers. Individualized bast fibers include fibers derived from the flax and hemp plants. The nonwoven textile fabric is formed into a web while in a dry state and subsequently bonded to produce a nonwoven fabric.

Abstract: Methods, ovens, and associated apparatus. Ovens and methods are adapted for maintaining the quality of a pre-cooked food product. Rapid temperature and/or relative humidity restoration may be used. Ovens may include a partition movable to vary sizes of oven cavities. Ovens may include removable interior panels. Humidification mechanisms are adapted for generating water vapor which may be used to maintain the quality of a pre-cooked food product.

Abstract: An agricultural wrap includes a continuous planar main body formed of a flexible and permeable material, an amount of growing matter, and at least one irrigation tube. The body has first and second sides, first and second ends, an inner surface, an outer surface disposed against a base surface, and at least one aperture. With the growing matter disposed against the inner surface, the first and second sides are positioned around the growing matter to define a holding pocket. An irrigation tube being disposed against the main body and above the base surface leaks water that permeates through the main body and saturates the growing matter.