Abstract: The present disclosure is directed to methods and compositions for the prediction and treatment of immunotherapy-induced toxicities, as well as improved methods for the treatment of cancer with immunotherapies.

Abstract: Artificial ice skating rink assemblies that can used indoors or outdoors, in all seasons, that can be readily assembled with a reduced number of assembly parts and accessories being required, and it can be used with reduced maintenance demands. In one embodiment of this invention, there is an artificial ice skating rink consisting of a plurality of panel means for providing an ice skating surface, in which each panel means has an elongate channel disposed therein having longitudinal and transverse axes. Elongate spline means are provided for slideable insertion into a channel in a lateral direction along the transverse axis of that channel, and for slideable receipt of another channel of another panel means which is forced in a lateral direction into slideable engagement with the spline. In this way, separate panel means are retained together exclusively by the spline means against relative motion along the transverse axes of their respective channels.

Abstract: A low-friction composite structure according to the present invention comprises: (1) a core material with a uniform cross section and having dimensional stability, the core material having two substantially planar surfaces; and (2) at least one polymer layer adhesively attached to one of the substantially planar faces of the core material, the polymer layer having applied thereto a friction-reducing ingredient selected from the group consisting of silicone resins and silicone oils. Preferably, the low-friction composite structure is constructed in segments, with the segments being assembled by groove-and-spline assembly to form the structure, such as through splines. Various additives, such as anti-oxidants, titanium dioxide, thermic stabilizers, ultraviolet stabilizers, hydrophobic ingredients, release agents, and anti-static ingredients, can be added to the polymer layer. Preferably, the polymer is polyethylene.