Abstract: There are provided compounds of formula (I), ##STR1## wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro or cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents N(X) or CH(--(CH.sub.2).sub.m --NXY); U represents NH, O or CH.sub.2 ; V represents (CH.sub.2).sub.a ; W represents (CH.sub.2).sub.b ; a, b, m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy.

Abstract: The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include stroke, schizophrenia, anxiety, and pain.

Abstract: A security door assembly or locking mechanism for securing a single door in locking engagement with an adjacent door jamb structure comprises a first elongate metal blade to be received by a matching elongate groove in a vertical edge of a door. A second elongate metal blade is received by a matching groove in an upper horizontal edge of the door. Mechanical devices are provided for moving said blades partially from the grooves in the door into engagement with receiving grooves in the adjacent door jamb structure to lock the door. The vertical and horizontal blades are coupled together by a linkage mechanism which enables both blades to be operated simultaneously upon actuation of a single lever or knob. The blades and the linkage mechanism are mounted in an L-shaped housing inserted into grooves formed in adjacent edges of the door. Elongate metal strips are provided to be mounted over the grooves in the door jamb.

Abstract: Amidine derivative compounds of formula I as defined in the Specification having nitric oxide synthetase inhibitory activity as well as processes for the preparation of and compositions containing said compounds are described.

Abstract: Compounds of the formula (I) ##STR1## wherein D represents a 5-membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro, cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents (N(X) or CH(--(CH.sub.2).sub.m --NXY); U represents NH, O or CH.sub.2 ; V represents (CH.sub.2).sub.b ; a, b,m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy.

Abstract: There are provided novel compounds of formula I ##STR1## wherein D, R.sup.1, R.sup.2, R.sup.3, X and p are as defined in the specification together with processes for their preparation, compositions containing them and their use in therapy.Compounds of formula I are expected to be useful inter alia in the treatment of neurodegenerative disorders.

Abstract: A security door assembly or locking mechanism for securing a single door in locking engagement with an adjacent door jamb structure comprises a first elongate metal blade to be received by a matching elongate groove in a vertical edge of a door. A second elongate metal blade is received by a matching groove in an upper horizontal edge of the door. Mechanical devices are provided for moving said blades partially from the grooves in the door into engagement with receiving grooves in the adjacent door jamb structure to lock the door. The vertical and horizontal blades are coupled together by a linkage mechanism which enables both blades to be operated simultaneously upon actuation of a single lever or knob. The blades and the linkage mechanism are mounted in an L-shaped housing inserted into grooves formed in adjacent edges of the door. Elongate metal strips are provided to be mounted over the grooves in the door jamb.