Abstract: A pleural manometry catheter comprises two tubes and a pressure transducer. The first tube provides a first flow path from the pleural cavity to the pressure transducer. The second tube provides a second flow path from the pleural cavity such that fluid can be drained from the pleural cavity. The pressure transducer comprises a processor for processing, continuously, the real-time fluctuations in the pressure of the second flow path and therefore the pleural cavity as fluid is aspirated from it via the first tube.

Abstract: Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4).

Abstract: Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4).

Abstract: Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4).

Abstract: Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4).

Abstract: A pleural manometry catheter comprises two tubes and a pressure transducer. The first tube provides a first flow path from the pleural cavity to the pressure transducer. The second tube provides a second flow path from the pleural cavity such that fluid can be drained from the pleural cavity. The pressure transducer comprises a processor for processing, continuously, the real-time fluctuations in the pressure of the second flow path and therefore the pleural cavity as fluid is aspirated from it via the first tube.

Abstract: A turbocharger assembly has a housing (1) in which is formed a turbine volute inlet duct (4) having a butterfly valve (8) disposed therein and a bypass duct (6) which contains a swing valve (15), the valves being operable to control the flow of exhaust gas through each duct. A link member (30) is mounted for rotation about the pivot axis (21) of the swing valve (15) and has an opening in which an actuating pin (20) engages with a tolerance fit so as to non-rotatably connect the swing valve (15) to the link plate (30). The link plate also has an elongated channel (34) along which an actuating pin (13) of the butterfly valve travels upon rotation of the link plate (30) about the pivot axis (21). The elongated channel has a first portion (34a) which extends along an arc centred on the axis of rotation (21) and a second portion (34b) which extends along an arc whose centre is offset from said axis (21).

Abstract: A turbocharger assembly has a housing (1) in which is formed a turbine volute inlet duct (4) having a butterfly valve (8) disposed therein and a bypass duct (6) which contains a swing valve (15), the valves being operable to control the flow of exhaust gas through each duct. A link member (30) is mounted for rotation about the pivot axis (21) of the swing valve (15) and has an opening in which an actuating pin (20) engages with a tolerance fit so as to non-rotatably connect the swing valve (15) to the link plate (30). The link plate also has an elongated channel (34) along which an actuating pin (13) of the butterfly valve travels upon rotation of the link plate (30) about the pivot axis (21). The elongated channel has a first portion (34a) which extends along an arc centered on the axis of rotation (21) and a second portion (34b) which extends along an arc whose center is offset from said axis (21).

Abstract: A first member, such as a primer cartridge (33), is inserted in an aperture in a second member, such as a chamber (8) in a gun breech block (4,5), by means of an apparatus such as a primer loader (52), comprising a tubular member whose bore (16) serves as a guide for positioning the first member and which is aligned with the aperture in the second member. A fourth member, such as a ramming rod (19), may be provided to move the first member into the guide and thence into the aperture as the fourth member advances from a first to a second position. In the case where the primer cartridge passes across a gap (18) in order to enter the aperture, the fourth member may be arranged to advance an additional distance to a third position wherein the additional distance is not less than the width of the gap, the additional distance being the permitted movement of a fifth member, such as a slidable bush (38), between two positions.

Abstract: This invention is concerned with methods and materials for producing unitary silicon nitride structures by means of joining together at least two silicon based bodies with an intervening mixture of silicon powder and a heat removable liquid binder therefor between the joining faces, mantaining said faces in juxtaposition and slowly heating the assembly in a nitriding atmosphere to remove the liquid binder and to convert the material of said bodies and the intervening silicon powder into a unitary structure.