Patents by Inventor Edwin B. George

Edwin B. George has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC PLASMODIUM ANTIGENS, COMPOSITIONS, AND USES THEREOF
    Publication number: 20240083956
    Abstract: Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.
    Type: Application
    Filed: September 19, 2023
    Publication date: March 14, 2024
    Inventors: John H. Adams, Christopher L. King, Niraj H. Tolia, Edwin Chen, Nichole Diane Salinas, Miriam Thankam George, Francis B. Ntumngia, Samantha Jones Barnes
  • Stimulating nerve growth with immunophilins
    Patent number: 6080753
    Abstract: Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: June 27, 2000
    Assignee: Johns Hopkins University School of Medicine
    Inventors: W. Ernest Lyons, Edwin B. George, Ted M. Dawson, Joseph P. Steiner, Solomon H. Snyder
  • Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
    Patent number: 5898029
    Abstract: Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
    Type: Grant
    Filed: April 12, 1994
    Date of Patent: April 27, 1999
    Assignee: The John Hopkins University
    Inventors: W. Ernest Lyons, Edwin B. George, Ted M. Dawson, Joseph P. Steiner, Solomon H. Snyder
  • Alignment, code and power test of airborne laser designators
    Patent number: 5734466
    Abstract: This invention relates to laser guided weapon systems and in particular to boresighting a designator laser to a forward looking infrared (FLIR) sighting system that is at a wavelength other than that of the laser with sufficient accuracy, confirming adequate power level available for designation and that the proper pulse rate code has been selected and is being transmitted. Due to the nature of the designation laser being at a different bandwidth than the FLIR, the positioning of the laser spot is not visible to the targeting system and the initial system alignment is depended on for accuracy and precision. This invention presents a way of addressing three aspects of laser designation prior to weapon use. This is achieved through the use of a beamsplitter and thermal resistor that appear to be at the same point of space to the targeting system. The offsets are measured and then used to correct the misalignment.
    Type: Grant
    Filed: September 27, 1995
    Date of Patent: March 31, 1998
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Edwin B. George, Steven A. Marlow