Patents by Inventor Edwin Johannes Adrianus Veldhuizen
Edwin Johannes Adrianus Veldhuizen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240050526Abstract: The invention relates to methods for activating, inducing or promoting innate immune memory in a subject in need thereof comprising administering to the subject CATH2 or a derivative thereof. The invention further relates to methods of improving antimicrobial treatment in a subject in need thereof comprising administering to the subject CATH2 or a derivative thereof and to a use of CATH2 or a derivative thereof as an adjuvant for a pathogen-specific vaccine.Type: ApplicationFiled: December 17, 2021Publication date: February 15, 2024Inventors: Hendrik Peter HAAGSMAN, Albert VAN DIJK, Edwin Johannes Adrianus VELDHUIZEN
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Publication number: 20230382961Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: ApplicationFiled: February 8, 2023Publication date: November 30, 2023Applicant: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Patent number: 11603391Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: GrantFiled: October 13, 2020Date of Patent: March 14, 2023Assignee: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Patent number: 11186619Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: April 10, 2019Date of Patent: November 30, 2021Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20210246177Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: ApplicationFiled: October 13, 2020Publication date: August 12, 2021Applicant: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Patent number: 10829524Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: GrantFiled: May 8, 2015Date of Patent: November 10, 2020Assignee: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Publication number: 20190233483Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Applicant: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Patent number: 10301363Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: March 26, 2015Date of Patent: May 28, 2019Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20170145065Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retro-inverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: ApplicationFiled: May 8, 2015Publication date: May 25, 2017Applicant: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Publication number: 20150197547Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: March 26, 2015Publication date: July 16, 2015Inventors: Floris Jacob Bikker, Albert van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree van der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Patent number: 9006174Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: GrantFiled: February 12, 2010Date of Patent: April 14, 2015Assignee: Universiteit Utrecht Holding B.V.Inventors: Floris Jacob Bikker, Albert Van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree Van Der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek
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Publication number: 20120093844Abstract: The invention concerns derivatives of CMAP27, which have a good antimicrobial activity and a low haemolytic activity as compared to the wild-type CMAP27 peptide. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. Further comprised in the invention is the use of CMAP27 and/or its derivatives as adjuvant.Type: ApplicationFiled: February 12, 2010Publication date: April 19, 2012Inventors: Floris Jacob Bikker, Albert Van Dijk, Rosalia Mars-Groenendijk, Edwin Johannes Adrianus Veldhuizen, Desiree Van Der Kleij, Hendrik Haagsman, Elisabeth Margaretha Molhoek