Patents by Inventor Edwin Lowe

Edwin Lowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10994646
    Abstract: A trailer assembly has a frame, wheels attached to and bearing the frame and a hopper mounted on the frame. A front conveyor belt is mounted in a front part of the hopper and is operable to rearwardly convey contents of the hopper overlying the belt. A rear conveyor belt is mounted in a rear part of the hopper and is operable in a first mode to rearwardly convey contents of the hopper overlying the rear belt and is operable in a second mode to forwardly convey contents of the hopper overlying the second conveyor belt. Depending on the direction of conveyance of the rear conveyor belt, the two conveyor belts can be operated either to convey contents for dumping through a rear gate or to convey contents for dumping through a bottom gate.
    Type: Grant
    Filed: June 13, 2020
    Date of Patent: May 4, 2021
    Inventor: James Edwin Lowe
  • Publication number: 20200391646
    Abstract: A trailer assembly has a frame, wheels attached to and bearing the frame and a hopper mounted on the frame. A front conveyor belt is mounted in a front part of the hopper and is operable to rearwardly convey contents of the hopper overlying the belt. A rear conveyor belt is mounted in a rear part of the hopper and is operable in a first mode to rearwardly convey contents of the hopper overlying the rear belt and is operable in a second mode to forwardly convey contents of the hopper overlying the second conveyor belt. Depending on the direction of conveyance of the rear conveyor belt, the two conveyor belts can be operated either to convey contents for dumping through a rear gate or to convey contents for dumping through a bottom gate.
    Type: Application
    Filed: June 13, 2020
    Publication date: December 17, 2020
    Inventor: James Edwin Lowe
  • Publication number: 20190202905
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 4, 2019
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Patent number: 10280219
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: May 7, 2019
    Assignees: AMGEN FREMONT INC., WARNER-LAMBERT COMPANY LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Publication number: 20170275354
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: June 5, 2017
    Publication date: September 28, 2017
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Patent number: 9718883
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: August 1, 2017
    Assignees: Amgen Fremont Inc., Warner-Lambert Company LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Publication number: 20160244519
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: October 27, 2015
    Publication date: August 25, 2016
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Publication number: 20120244167
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: April 27, 2012
    Publication date: September 27, 2012
    Applicants: WARNER-LAMBERT COMPANY LLC, AMGEN FREMONT INC.
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimée Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Patent number: 8188249
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: May 29, 2012
    Assignees: Amgen Fremont Inc., Warner-Lambert Company LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Patent number: 8067704
    Abstract: A system and method for weighing varying throughput of conveyed particulate material. The system has a weighing unit for measuring weight of material conveyed on a span of the conveyor and a speed monitoring unit to monitor the speed of the conveyor. A control module is programmed to calculate the instant value of material conveyed per unit length of the conveyor. An output from the control module reduces conveyor speed in response to a reduction in measured weight of material conveyed and increases conveyor speed in response to an increase in measured weight of material conveyed. High accuracy of measurement of the weight of particulate material being conveyed even when the conveyor is lightly loaded.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: November 29, 2011
    Assignee: Equipfix
    Inventors: James Edwin Lowe, Andrew James Lowe, Kevin Dalton Lowe
  • Publication number: 20100247545
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Applicants: AMGEN FREMONT INC., WARNER-LAMBERT COMPANY LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimée Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Patent number: 7728113
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: June 1, 2010
    Assignees: Amgen Fremont Inc., Warner-Lambert Company LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimée Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Publication number: 20100059291
    Abstract: A system and method for weighing varying throughput of conveyed particulate material. The system has a weighing unit for measuring weight of material conveyed on a span of the conveyor and a speed monitoring unit to monitor the speed of the conveyor. A control module is programmed to calculate the instant value of material conveyed per unit length of the conveyor. An output from the control module reduces conveyor speed in response to a reduction in measured weight of material conveyed and increases conveyor speed in response to an increase in measured weight of material conveyed. High accuracy of measurement of the weight of particulate material being conveyed even when the conveyor is lightly loaded.
    Type: Application
    Filed: February 11, 2009
    Publication date: March 11, 2010
    Applicant: Equipfix
    Inventors: James Edwin Lowe, Andrew James Lowe, Kevin Dalton Lowe
  • Patent number: 7592430
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: September 22, 2009
    Assignees: Amgen Fremont, Warner-Lambert Company, LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimée Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Publication number: 20080254032
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: August 20, 2007
    Publication date: October 16, 2008
    Applicants: Abgenix, Inc., Warner-Lambert Company LLC
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Patent number: 7326414
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: February 5, 2008
    Assignees: Warner-Lambert Company LLC, Abgenix, Inc.
    Inventors: Vahe Bedian, Madhav Narasimha Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimée Kellermann, Joseph Edwin Low, James Leslie Mobley
  • Publication number: 20070128324
    Abstract: The invention is a process for preparing a yoghurt with a desired gel strength. It is based on the unexpected observation that gel strength can be varied by varying the pH to an optimum at a given weight ratio of casein to whey protein. Whey protein is added to a milk and the casein:whey protein weight ratio is calculated. The optimum pH for that ratio is determined. The milk solution is then adjusted to that pH, heated to denature the whey protein and formed into yoghurt by known methods. The gel strength of the resulting yoghurt is determined by the optimum pH used in the heating step.
    Type: Application
    Filed: August 19, 2004
    Publication date: June 7, 2007
    Inventor: Edwin Lowe
  • Patent number: 6972298
    Abstract: The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: December 6, 2005
    Assignee: Warner-Lambert Company
    Inventors: Vijaykumar M. Baragi, Madhav Narasimha Devalaraja, Joseph Edwin Low, Vaishalee A. Padgaonkar
  • Patent number: 6548499
    Abstract: Quinoxaline compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in the treatment of a chemokine-mediated disease wherein the chemokine binds to an IL-8a (CXCR1) or b (CXCR2) receptor such as a chemokine-mediated disease selected from psoriasis, or atopic distress syndrome, arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, gastric ulcer, septic shock, endotoxic shock, gram-negative sepsis, toxic shock syndrome, stroke, cardiac and renal reperfusion injury, glomerulo-nephritis, or thrombosis, Alzheimer's disease, graft versus host reaction, allograft rejections, or allergic diseases.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: April 15, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth G. Carson, David Thomas Connor, Jie Jack Li, Joseph Edwin Low, Jay R. Luly, Steven Robert Miller, Bruce David Roth, Bharat Kalidas Trivedi
  • Publication number: 20030055095
    Abstract: The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor.
    Type: Application
    Filed: May 9, 2002
    Publication date: March 20, 2003
    Inventors: Vijaykumar M. Baragi, Madhav Narasimha Devalaraja, Joseph Edwin Low, Vaishalee A. Padgaonkar