Patents by Inventor EDWIN LOZANO

EDWIN LOZANO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mixed mode cation exchange chromatography ligands based on 1,3-dioxoisoindolin-2-yl structures
    Patent number: 12263467
    Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
    Type: Grant
    Filed: July 28, 2023
    Date of Patent: April 1, 2025
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Christopher Belisle, Jiali Liao, Edwin Lozano
  • MIXED MODE CATION EXCHANGE CHROMATOGRAPHY LIGANDS BASED ON 1,3-DIOXOISOINDOLIN-2-YL STRUCTURES
    Publication number: 20240001338
    Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
    Type: Application
    Filed: July 28, 2023
    Publication date: January 4, 2024
    Inventors: CHRISTOPHER BELISLE, JIALI LIAO, EDWIN LOZANO
  • Mixed mode cation exchange chromatography ligands based on 1,3-dioxoisoindolin-2-yl structures
    Patent number: 11731108
    Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
    Type: Grant
    Filed: March 17, 2022
    Date of Patent: August 22, 2023
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Christopher Belisle, Jiali Liao, Edwin Lozano
  • MIXED MODE CATIONIC EXCHANGE CHROMATOGRAPHY LIGANDS BASED ON SUBSTITUTED 2-BENZAMIDO ACETIC ACID STRUCTURES
    Publication number: 20230127357
    Abstract: The subject invention pertains to mixed mode chromatography ligands and chromatography matrices suitable for the purification of proteins from biological sources or biological samples. Methods of making chromatography matrices comprising the disclosed ligands and using the disclosed chromatography matrices are also provided.
    Type: Application
    Filed: October 17, 2022
    Publication date: April 27, 2023
    Inventors: CHRISTOPHER BELISLE, JIALI LIAO, CALLISTA KATRINA ASUNCION, EDWIN LOZANO
  • MIXED MODE CATION EXCHANGE CHROMATOGRAPHY LIGANDS BASED ON 1,3-DIOXOISOINDOLIN-2-YL STRUCTURES
    Publication number: 20220305460
    Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-droxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 29, 2022
    Inventors: CHRISTOPHER BELISLE, JIALI LIAO, EDWIN LOZANO