Patents by Inventor Edwin M. Stone

Edwin M. Stone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE NUCLEOTIDE POLYMORPHISMS AND GENES ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION
    Publication number: 20110104154
    Abstract: The invention provides genes and polymorphisms associated with AMD, and methods for diagnosing an increased risk of AMD in a patient who has at least one of the AMD-associated polymorphisms as provided.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 5, 2011
    Applicants: ALCON RESEARCH, LTD., IOWA RESEARCH FOUNDATION, UNIVERSITY OF
    Inventors: Abbot F. Clark, Edwin M. Stone, Val C. Sheffield, John Fingert, Thomas L. Casavant, Todd Scheetz, Terry Braun, A. Jason Grundstad
  • Diagnostics and therapeutics for glaucoma
    Patent number: 7807355
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: October 5, 2010
    Assignees: Alcon, Inc., University of Iowa Research Foundation
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • Diagnostics and Therapeutics For Glaucoma
    Publication number: 20090226425
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Application
    Filed: April 9, 2009
    Publication date: September 10, 2009
    Applicants: ALCON, INC., UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • Bardet-biedl susceptibility gene and uses thereof
    Patent number: 7045317
    Abstract: The present invention relates to the identification of a gene, now designated BBS4, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. The human BBS4 protein disclosed herein is 519 amino acids in length and is coded for by a gene spanning 16 exons. Homologs have been identified in mouse, rat, zebrafish. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: May 16, 2006
    Assignee: University of Iowa Research Foundation
    Inventors: Val C. Sheffield, Kirk Mykytyn, Edwin M. Stone
  • Diagnostics and therapeutics for glaucoma
    Patent number: 7033755
    Abstract: Methods and compositions for diagnosing and treating glaucoma are disclosed.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: April 25, 2006
    Assignees: Alcon, Inc., University of Iowa Research Foundation
    Inventors: Abbot F. Clark, John Fingert, Loretta McNatt, Edwin M. Stone, Wan-Heng Wang
  • Identification of a gene causing the most common form of bardet-biedl syndrome and uses thereof
    Patent number: 6962788
    Abstract: The present invention relates to the identification of a gene, mutated at the most common locus now designated BBS1, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypogonadism, mental retardation, renal cancer and other renal abnormalities, retinopathy and polydactyly or limb deformities. The human BBS1 protein disclosed herein is composed of 17 exons and spans approximately 23 kb. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: November 8, 2005
    Assignee: University of Iowa Research Foundation
    Inventors: Val C. Sheffield, Kirk Mykytyn, Darryl Y. Nishimura, Edwin M. Stone, Charles C. Searby
  • Glaucoma therapeutics and diagnostics
    Patent number: 6956103
    Abstract: Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: October 18, 2005
    Assignee: The University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield, Wallace L. M. Alward, John Fingert
  • Methods to identify modulators of FKHL7 DNA-binding activity
    Patent number: 6833239
    Abstract: Methods and compositions for treating a congenital heart disease and methods and compositions for prognosing or diagnosing a congenital heart disease in a subject are disclosed.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: December 21, 2004
    Assignee: The University of Iowa Research Foundation
    Inventors: Val C. Sheffield, Wallace L. M. Alward, Edwin M. Stone, Darryl Nishimura, Shiva Patil
  • Identification of a gene causing the most common form of Bardet-Biedl Syndrome and uses thereof
    Publication number: 20030232375
    Abstract: The present invention relates to the identification of a gene, mutated at the most common locus now designated BBS1, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypogonadism, mental retardation, renal cancer and other renal abnormalities, retinopathy and polydactyly or limb deformities. The human BBS1 protein disclosed herein is composed of 17 exons and spans approximately 23 kb. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
    Type: Application
    Filed: May 28, 2003
    Publication date: December 18, 2003
    Applicant: The University of Iowa Research Foundation
    Inventors: Val C. Sheffield, Kirk Mykytyn, Darryl Y. Nishimura, Edwin M. Stone, Charles C. Searby
  • Bardet-biedl susceptibility gene and uses thereof
    Publication number: 20030170645
    Abstract: The present invention relates to the identification of a gene, now designated BBS4, that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation, renal cancer and other abnormalities, retinopathy and hypogonadism. The human BBS4 protein disclosed herein is 519 amino acids in length and is coded for by a gene spanning 16 exons. Homologs have been identified in mouse, rat, zebrafish. Methods of use for the gene, for example in diagnosis and therapy of BBS and in drug screening, also are described.
    Type: Application
    Filed: April 2, 2002
    Publication date: September 11, 2003
    Inventors: Val C. Sheffield, Kirk Mykytyn, Edwin M. Stone
  • Macular degeneration diagnostics and therapeutics
    Publication number: 20030138798
    Abstract: Therapeutics and diagnostics based on the identification of genetic mutations, which cause Macular Degeneration (MD) is disclosed.
    Type: Application
    Filed: July 8, 2002
    Publication date: July 24, 2003
    Applicant: University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield
  • Macular degeneration diagnostics and therapeutics
    Patent number: 6593104
    Abstract: Therapeutics and diagnostics based on the identification of genetic mutations, which cause Macular Degeneration (MD) are disclosed.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: July 15, 2003
    Assignee: University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield
  • Glaucoma therapeutics and diagnostics
    Publication number: 20030077587
    Abstract: Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.
    Type: Application
    Filed: September 12, 2001
    Publication date: April 24, 2003
    Applicant: University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield, Wallace L.M. Alward, John Fingert
  • Macular degeneration diagnostics and therapeutics
    Patent number: 6417342
    Abstract: Therapeutics and diagnostics based on the identification of genetic mutations, which cause Macular Degeneration (MD) is disclosed.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 9, 2002
    Assignee: University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield
  • Glaucoma therapeutics and diagnostics
    Patent number: 6403307
    Abstract: Methods and compositions for preventing and treating glaucoma; and glaucoma diagnostics are disclosed.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: June 11, 2002
    Assignee: University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield, Wallace L. M. Alward, John Fingert
  • Glaucoma compositions
    Patent number: 6271026
    Abstract: Glaucoma compositions comprising the GLC1A gene are disclosed.
    Type: Grant
    Filed: March 21, 1997
    Date of Patent: August 7, 2001
    Assignee: The University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield, Wallace L. M. Alward
  • Glaucoma therapeutics and diagnostics based on a novel human transcription factor
    Patent number: 6207450
    Abstract: Methods and compositions for treating glaucoma and methods and compositions for prognosing or diagnosing glaucoma in a subject are disclosed.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: March 27, 2001
    Assignee: University of Iowa Research Foundation
    Inventors: Val C. Sheffield, Wallace L. M. Alward, Edwin M. Stone, Darryl Nishimura, Shiva Patil
  • Therapeutics and diagnostics for congenital heart disease based on a novel human transcription factor
    Patent number: 6087107
    Abstract: Methods and compositions for treating a congenital heart disease and methods and compositions for prognosing or diagnosing a congenital heart disease in a subject are disclosed.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: July 11, 2000
    Assignee: The University of Iowa Research Foundation
    Inventors: Val C. Sheffield, Wallace L. M. Alward, Edwin M. Stone, Darryl Nishimura, Shiva Patil
  • DNA diagnostics for glaucoma
    Patent number: 5925748
    Abstract: Methods and kits for diagnosing a subject with glaucoma or with a predisposition for developing glaucoma are disclosed.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: July 20, 1999
    Assignee: The University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield, Wallace L.M. Alward
  • Diagnostics based on a glaucoma causing gene
    Patent number: 5916778
    Abstract: Methods and compositions for glaucoma diagnostics are disclosed.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: June 29, 1999
    Assignee: University of Iowa Research Foundation
    Inventors: Edwin M. Stone, Val C. Sheffield, Wallace L. M. Alward