Patents by Inventor Edwin M. Westbrook

Edwin M. Westbrook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals, molecular complexes, and methods of developing lead compounds for inhibitors of bacterial IMPDH
    Patent number: 6826488
    Abstract: The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of bacterial IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes that comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: November 30, 2004
    Assignee: The University of Chicago
    Inventors: Frank R. Collart, Eliezer Huberman, Andrezej Joachimiak, Rongguang Zhang, Edwin M. Westbrook
  • High intensity x-ray source using liquid gallium target
    Patent number: 4953191
    Abstract: A high intensity x-ray source that uses a flowing stream of liquid gallium as a target with the electron beam impinging directly on the liquid metal.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: August 28, 1990
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Robert K. Smither, Gordon S. Knapp, Edwin M. Westbrook, George A. Forster