Patents by Inventor Edwin Oosterbroek

Edwin Oosterbroek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220137079
    Abstract: A method for operating a laboratory system comprising laboratory instruments and a laboratory information system is presented. The method comprises grouping laboratory instruments into instrument cluster(s) and providing a cluster manager thereto. The plurality of laboratory instruments publishes their instrument resource descriptions. Each cluster manager maintains an inventory of cluster resources and publishes a list of processing capabilities of the instrument cluster. The laboratory information system assigns processing of test order(s) to instrument clusters. Each cluster manager assigns resources of the laboratory instruments corresponding to test orders from the laboratory information system in view of the inventory of cluster resources. Each laboratory instrument carries out the processing step(s) on the biological sample as instructed by the cluster manager.
    Type: Application
    Filed: January 13, 2022
    Publication date: May 5, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Edwin Oosterbroek, Urs Suter, Vaclav Cechticky
  • Patent number: 11278883
    Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: March 22, 2022
    Assignees: Roche Diagnostics Hematology, Inc., Roche Diagnostics Operations, Inc.
    Inventors: Ertan Ergezen, Stephen Conroy, Rijk Edwin Oosterbroek, Claudio Cherubini
  • Patent number: 11262370
    Abstract: A method for operating a laboratory system comprising laboratory instruments and a laboratory information system is presented. The method comprises grouping laboratory instruments into instrument cluster(s) and providing a cluster manager thereto. The plurality of laboratory instruments publishes their instrument resource descriptions. Each cluster manager maintains an inventory of cluster resources and publishes a list of processing capabilities of the instrument cluster. The laboratory information system assigns processing of test order(s) to instrument clusters. Each cluster manager assigns resources of the laboratory instruments corresponding to test orders from the laboratory information system in view of the inventory of cluster resources. Each laboratory instrument carries out the processing step(s) on the biological sample as instructed by the cluster manager.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: March 1, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Edwin Oosterbroek, Urs Suter, Vaclav Cechticky
  • Patent number: 11067565
    Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: July 20, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
  • Publication number: 20190344260
    Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.
    Type: Application
    Filed: December 29, 2017
    Publication date: November 14, 2019
    Inventors: Ertan Ergezen, Stephen Conroy, Rijk Edwin Oosterbroek, Claudio Cherubini
  • Publication number: 20190072575
    Abstract: A method for operating a laboratory system comprising laboratory instruments and a laboratory information system is presented. The method comprises grouping laboratory instruments into instrument cluster(s) and providing a cluster manager thereto. The plurality of laboratory instruments publishes their instrument resource descriptions. Each cluster manager maintains an inventory of cluster resources and publishes a list of processing capabilities of the instrument cluster. The laboratory information system assigns processing of test order(s) to instrument clusters. Each cluster manager assigns resources of the laboratory instruments corresponding to test orders from the laboratory information system in view of the inventory of cluster resources. Each laboratory instrument carries out the processing step(s) on the biological sample as instructed by the cluster manager.
    Type: Application
    Filed: August 20, 2018
    Publication date: March 7, 2019
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Edwin Oosterbroek, Urs Suter, Vaclav Cechticky
  • Publication number: 20180209964
    Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 26, 2018
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
  • Patent number: 9939429
    Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: April 10, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
  • Patent number: 9638612
    Abstract: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: May 2, 2017
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Judith Brand-Meier, Claudio Cherubini, Andreas Drechsler, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
  • Patent number: 9612192
    Abstract: A cuvette comprising a body having an upper part comprising an upper open top portion and upper walls forming four upper inner edges and an upper open bottom portion with a first substantially rectangular cross-section in a plane A-A; and a lower measurement chamber comprising a lower closed bottom portion and lower walls forming four lower inner edges and a lower open top portion with a second substantially rectangular cross-section in a plane B-B smaller than the first cross-section in the plane A-A. An abrupt transition zone is positioned between the plane A-A and the plane B-B comprising four transition inner edges connecting the four lower inner edges to the upper open bottom portion. At least in the plane B-B the lower inner edges comprise fillets having a first radius (R1). At least in the plane A-A the upper inner edges comprise fillets having a second radius (R2) being larger than (R1).
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: April 4, 2017
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Andreas Drechsler, Rijk Edwin Oosterbroek
  • Patent number: 9606140
    Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: March 28, 2017
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Geza Burghardt, Michael Glauser, Oliver Gutmann, Daniel Mueller, Edwin Oosterbroek, Roger Sandoz, Emad Sarofim, Goran Savatic
  • Patent number: 9442109
    Abstract: Centrifugal force based microfluidic systems for the automated analysis of fluids involving the use of magnetically responsive particles and methods thereof are disclosed. A magnet is fixed to a supporting device of the system in correspondence to a retention zone of the system so as to rotate therewith and to generate a magnetic field which magnetically manipulates the magnetically responsive particles contained in a reaction chamber of the system.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: September 13, 2016
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rijk Edwin Oosterbroek, Mario Curcio, Stephan Korner, Brigitte Niederberger
  • Patent number: 9151750
    Abstract: Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: October 6, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Christoph Boehm, Brigitte Niederberger, Rijk Edwin Oosterbroek, Susanne Wuerl
  • Patent number: 8940249
    Abstract: A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: January 27, 2015
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rainer D. Jaeggi, Oliver Gutmann, Michael Glauser, Heinz-Michael Hein, Edwin Oosterbroek, Michael Andreas Heinrich
  • Publication number: 20150017681
    Abstract: A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
    Type: Application
    Filed: July 8, 2014
    Publication date: January 15, 2015
    Inventors: Andreas Drechsler, Edwin Oosterbroek, Emad Sarofim, Heiko Schwertner
  • Patent number: 8911684
    Abstract: A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: December 16, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Manfred Augstein, Christoph Boehm, Carlo Effenhauser, Rijk Edwin Oosterbroek, Susanne Wuerl
  • Publication number: 20140360269
    Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.
    Type: Application
    Filed: May 23, 2014
    Publication date: December 11, 2014
    Applicant: Roche Diagnostics Operations, In.c
    Inventors: Geza Burghardt, Michael Glauser, Oliver Gutmann, Daniel Mueller, Edwin Oosterbroek, Roger Sandoz, Emad Sarofim, Goran Savatic
  • Publication number: 20140329249
    Abstract: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
    Type: Application
    Filed: April 25, 2014
    Publication date: November 6, 2014
    Applicant: Roche Molecular Systems, Inc.
    Inventors: Judith Brand-Meier, Claudio Cherubini, Andreas Drechsler, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
  • Patent number: 8808647
    Abstract: Systems, methods and multi-well plates comprising an array of wells for thermal treatment of chemical or biological samples are disclosed. Each of the wells comprises a bottom opening, an upper opening, inner side walls extending from the bottom opening to the upper opening, a protrusion extending from the inner side walls into the well with a first cross-sectional area and located at a height from the bottom opening which is smaller than the height from the upper opening. A sample chamber with a second cross-sectional area is formed between the bottom opening and the protrusion. An upper chamber with a third cross-sectional area is formed between the protrusion and the upper opening, and in which the first cross-sectional area is smaller than the third cross-sectional area and smaller than or equal to the second cross-sectional area.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: August 19, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Nicole Gwerder, Martin Kopp, Edwin Oosterbroek, Emad Sarofim
  • Patent number: 8778696
    Abstract: A microfluidic processing unit for the automated processing of liquid samples and method thereof are disclosed. In one embodiment, the unit comprises first and second main channels connected to a pump for generating a negative or positive pressure therein; a sample channel which supplies a liquid sample is connectable to a sample vessel containing the liquid sample, the sample channel communicates with the first main channel and is equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid samples, each of the reagent channels communicating with the first or second main channel and being equipped with an on/off valve; and a reaction chamber for reacting a sample and reagent, the reaction chamber being connected to the first and second main channels via at least one on/off valve.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: July 15, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Oliver Gutmann, Edwin Oosterbroek, Michael Glauser, Michael Andreas Heinrich, Jean-Pierre Bolliger, Emad Sarofim, Rainer D. Jaeggi