Abstract: Disclosed are compounds which may be utilized to inhibit transcription by RNA Polymerase II (Pol II), and in particular to disrupt the Super Elongation Complex (SEC). The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with the biological activity of SEC, and in particular, diseases and disorders that are associated with high levels of expression of genes whose expression is SEC-dependent and that promote, support, or otherwise are required for the disease or disorder such as cancers.

Abstract: Disclosed are compounds which may be utilized to inhibit transcription by RNA Polymerase II (Pol II), and in particular to disrupt the Super Elongation Complex (SEC). The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with the biological activity of SEC, and in particular, diseases and disorders that are associated with high levels of expression of genes whose expression is SEC-dependent and that promote, support, or otherwise are required for the disease or disorder such as cancers.

Abstract: Biaxially stretched, heat shrinkable monolayer and multilayer films comprising very low density polyethylene terpolymers of monomers (a), (b) and (c), where (a) comprises ethylene, (b) comprises a C.sub.6 -C.sub.8 alpha-olefin and (c) comprises 1-butene or 1-hexene, have a very good combination of physical properties and processability including high shrinkage values and puncture resistance.

Abstract: A golf practice apparatus provides recording and instant playback of video images of a golfer's swing. A plurality of color video cameras are preferably employed to obtain video images of a swing from different angles. A video processing and storage unit digitally stores the images in memory for instant replay. Image processing and recording is automatically initiated when a golf ball is placed on a designated hitting area through the use of an infrared camera and image processing software that detects a golf ball in the IR camera's image. The IR camera is also used in conjunction with an IR flash unit to obtain snapshot images of a club head and ball just before and just after the golf club hits the ball. An optical sensor array is positioned adjacent the hitting area to detect the passage of a golf club toward the ball. The signals generated by the optical sensor array are employed by the image processing and storage unit to both calculate the club speed and control triggering of the flash unit.

Abstract: Biaxially stretched monolayer and multilayer films comprising blends of a 1-butene very low density polyethylene with a 1-hexene very low density polyethylene have improved combinations of properties including good puncture resistance and shrinkage values and unexpectedly good machine direction shrink force.

Abstract: There is disclosed a universal electrical conductor pattern for both multilayer and single layer test substrates for tape bonded hybrids which is adapted to accept semiconductor chips of various sizes and numbers of leads. The pattern consists of four sets of equally spaced parallel rectangularly shaped outer lead bonding pads which are orthogonally arranged in a repetitive sequence around a chip bonding pad. Each set of outer lead bonding pads consists of a first subset of six like pads arranged adjacently in registration along one edge of the chip bonding pad, and second and third subsets of two outer lead bonding pads each arranged on either side of said first subset in parallel relationship therewith but set back from the corners of the chip bonding pad. The rectangularly shaped outer lead bonding pads extend away from the respective edges of the chip bonding pad a predetermined distance so as to accommodate either twenty four, thirty two or forty pin lead frames having a standard twenty mil lead spacing.