Patents by Inventor Edwin W. Rubel

Edwin W. Rubel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for preventing or treating sensory hair cell death
    Patent number: 10399994
    Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: September 3, 2019
    Assignees: University of Washington, Oricula Therapeutics LLC, Fred Hutchinson Cancer Research Center
    Inventors: Julian Simon, Graham Johnson, Edwin W. Rubel, David W. Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
  • COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH
    Publication number: 20180022756
    Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
    Type: Application
    Filed: February 5, 2016
    Publication date: January 25, 2018
    Inventors: Julian Simon, Graham Johnson, Edwin W. Rubel, David W. Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
  • Compounds that protect against sensory hair cell death
    Patent number: 8232314
    Abstract: The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: July 31, 2012
    Assignees: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Henry C. Ou, Felipe Santos, Edwin W. Rubel, David W. Raible, Julian A. Simon
  • COMPOSITIONS AND METHODS FOR PROTECTING SENSORY HAIR CELLS
    Publication number: 20110135756
    Abstract: The invention provides compounds, compositions and methods that can be used for the attenuation of damage to sensory hair cells and symptoms thereof. More particularly, the invention identifies drugs that can be used to protect sensory hair cells from ototoxic medications, noise-induced damage and age-related loss.
    Type: Application
    Filed: December 8, 2010
    Publication date: June 9, 2011
    Applicants: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Kelly N. Owens, Anna L. Corke, Henry C. Ou, Edwin W. Rubel, David W. Raible, Julian A. Simon
  • COMPOUNDS THAT PROTECT AGAINST SENSORY HAIR CELL DEATH
    Publication number: 20090023751
    Abstract: The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.
    Type: Application
    Filed: January 15, 2008
    Publication date: January 22, 2009
    Applicants: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Henry C. Ou, Felipe Santos, Edwin W. Rubel, David W. Raible, Julian A. Simon