Patents by Inventor Edwin Weeber

Edwin Weeber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220152223
    Abstract: One aspect described herein relates to a recombinant adeno-associated virus (rAAV) vector and a method for use thereof or treating Angelman Syndrome. Another aspect described herein is a UBE3A rAAV vector and method for use thereof for treating a UBE3A deficiency, e.g. Angelman syndrome, in humans.
    Type: Application
    Filed: March 20, 2020
    Publication date: May 19, 2022
    Inventors: Antonio ARULANANDAM, Kevin NASH, Edwin WEEBER, Liangxian CAO, Min Jung KIM
  • Patent number: 10729744
    Abstract: Disclosed are methods of influencing, and enhancing, cognitive function and memory by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: August 4, 2020
    Assignees: University of South Florida, Vanderbilt University
    Inventors: Edwin Weeber, Lisa Zhao, Melinda Peters
  • Publication number: 20180236028
    Abstract: Disclosed are methods of influencing, and enhancing, cognitive function and memory by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
    Type: Application
    Filed: April 2, 2018
    Publication date: August 23, 2018
    Applicants: University of South Florida, Vanderbilt University
    Inventors: Edwin Weeber, Lisa Zhao, Melinda Peters
  • Patent number: 9962426
    Abstract: Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: May 8, 2018
    Assignees: University of South Florida, Vanderbilt University
    Inventors: Edwin Weeber, Lisa Zhao, Melinda Peters
  • Publication number: 20160271213
    Abstract: Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
    Type: Application
    Filed: December 15, 2015
    Publication date: September 22, 2016
    Applicants: University of South Florida, Vanderbilt University
    Inventors: Edwin Weeber, Lisa Zhao, Melinda Peters
  • Patent number: 9241975
    Abstract: Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
    Type: Grant
    Filed: August 9, 2011
    Date of Patent: January 26, 2016
    Assignees: University of South Florida, Vanderbilt University
    Inventors: Edwin Weeber, Lisa Zhao, Melinda Peters
  • Patent number: 9211401
    Abstract: An implantable neuronal prosthetic and method of manufacture thereof includes at least one elongated electrode shank adapted for arrangement in the brain having at least one electrode contact disposed on its surface and arranged to electrically couple with said brain. The at least one elongated electrode shank is formed form a single crystal cubic silicon carbide. An insulation layer of amorphous, polycrystalline, or single crystal silicon carbide is disposed over the elongated electrode shank; the insulation layer of amorphous, polycrystalline, or single crystal silicon carbide is removed from the at least one electrode contact. Signal control electronics are attached to the at least one elongated electrode shank and are in electrical communication with the at least one electrode contact. In an embodiment, a plurality of the at least one elongated electrode shanks are arranged into a matrix.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: December 15, 2015
    Assignee: University of South Florida
    Inventors: Christopher Leroy Frewin, Stephen E. Saddow, Edwin Weeber
  • Publication number: 20140067023
    Abstract: The microfabricated prosthetic device uses local, direct, and wavelength-specific optical stimulation to achieve an action potential from a single or small group of neurons within the central nervous system (CNS). The device is biocompatible, mechanically flexible, and optically transparent. The device can also use integrated electrodes for additional input/output (IO) locations, signal verification, feedback, wireless communication, and characterization of the electrochemically-evoked potential received from the activated neuron. The purpose of the device is to act as a neural interface prosthetic. The prosthetic is designed as the central component of a brain machine interface (BMI).
    Type: Application
    Filed: July 29, 2013
    Publication date: March 6, 2014
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Joseph J. Register, Stephen E. Saddow, Christopher L. Frewin, Edwin Weeber
  • Publication number: 20120232631
    Abstract: An implantable neuronal prosthetic and method of manufacture thereof includes at least one elongated electrode shank adapted for arrangement in the brain having at least one electrode contact disposed on its surface and arranged to electrically couple with said brain. The at least one elongated electrode shank is formed form a single crystal cubic silicon carbide. An insulation layer of amorphous, polycrystalline, or single crystal silicon carbide is disposed over the elongated electrode shank; the insulation layer of amorphous, polycrystalline, or single crystal silicon carbide is removed from the at least one electrode contact. Signal control electronics are attached to the at least one elongated electrode shank and are in electrical communication with the at least one electrode contact. In an embodiment, a plurality of the at least one elongated electrode shanks are arranged into a matrix.
    Type: Application
    Filed: May 24, 2012
    Publication date: September 13, 2012
    Applicant: University of South Florida
    Inventors: Christopher Leroy Frewin, Stephen E. Saddow, Edwin Weeber
  • Publication number: 20120058109
    Abstract: Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin-specific modulator or an agonist of a lipoprotein receptor to the subject. The lipoprotein receptor can be selected from candidates such as ApoER2 and VLDLR. As disclosed herein, agonists of the lipoprotein receptor for use with the inventive method include APC, Sep and Fc-RAP. In addition to administering exogenous Reelin, a Reelin-specific modulator, such as a recombinant Reelin fragment, can be used to increase Reelin levels and/or signaling.
    Type: Application
    Filed: August 9, 2011
    Publication date: March 8, 2012
    Applicants: VANDERBILT UNIVERSITY, UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edwin Weeber, Lisa Zhao, Melinda Peters