Patents by Inventor Efraim Lavie

Efraim Lavie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method And System For Production Of Radioisotopes, And Radioisotopes Produced Thereby
    Publication number: 20070297554
    Abstract: A system and method for the production of radioisotopes by the transmutation of target isotopic material bombarded by a continuous wave particle beam. An ion source generates a continuous wave ion beam, irradiating an isotope target, which is cooled by transferring heat away from the target at heat fluxes of at least about 1 kW/cm2.
    Type: Application
    Filed: September 20, 2005
    Publication date: December 27, 2007
    Inventors: Efraim Lavie, Ido Silverman, Alexander Arenshtam, Daniel Kijel, Lea Broshi, Eliahu Sayag
  • In-situ-generated solid radiation source based on Tungsten 188 /Rhenium 188 and use thereof
    Patent number: 6409943
    Abstract: A radiotheraputical source of Rhenium188 comprises metallic Tungsten188 or a metal oxide of Tungsten188. Therapeutic device using Rhenium188 comprise a radioactive source for the in situ generation of Rhenium188 from Tungsten188.
    Type: Grant
    Filed: April 25, 2000
    Date of Patent: June 25, 2002
    Assignee: The State of Israel, Atomic Energy Commission
    Inventors: Efraim Lavie, Daniel Kijel, Eliahu Sayag, Yehoshua Michael Bettan
  • Immunoconjugates and methods for their use in tumor therapy
    Patent number: 5084560
    Abstract: Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
    Type: Grant
    Filed: August 7, 1990
    Date of Patent: January 28, 1992
    Assignee: Oncogen
    Inventors: Karl E. Hellstrom, Ingegerd E. Hellestrom, Efraim Lavie
  • pH-sensitive immunoconjugates and methods for their use in tumor therapy
    Patent number: 4997913
    Abstract: Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: March 5, 1991
    Assignee: Oncogen
    Inventors: Karl E. Hellstrom, Ingegerd E. Hellstrom, Efraim Lavie