Patents by Inventor Efren G. Delos Santos

Efren G. Delos Santos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
    Patent number: 6071903
    Abstract: Compounds are provided having the following formula: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are defined in the specification, which have matrix metalloproteinase inhibiting activity.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: June 6, 2000
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos, Xuemei Du
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5849735
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: December 15, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Aranapakam M. Venkatesan, Efren G. Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5719278
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: February 17, 1998
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos, Xuemei Du, Marvin F. Reich
  • Fused heterocyclic azepines as vasopressin antagonists
    Patent number: 5696112
    Abstract: This invention relates to bicyclic non-peptide vasopressin antagonists useful in treating conditions where decreased vasopressin levels are desired, in conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction, the compounds of this invention having the core structure of ##STR1## wherein: E--Y is selected from the moieties --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, and ##STR2## the moiety ##STR3## includes an optionally substituted, fused 6-membered heterocyclic aromatic ring containing two nitrogen atoms, a fused 5-membered heterocyclic aromatic ring containing either a) one heteroatom selected from O, S or N; b) two N atoms; or one N atom and one O or S atom;and R.sup.1, R.sup.2, R.sup.3 and R.sub.b are as defined herein.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: December 9, 1997
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos
  • Tricyclic thieno-azepine vasopressin antagonists
    Patent number: 5654297
    Abstract: This invention relates to new bicyclic non-peptide vasopressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 5, 1997
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5624923
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 29, 1997
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Marvin F. Reich, Fuk-Wah Sum, Efren G. Delos Santos
  • Tricyclic benzazepine vasopressin antagonists
    Patent number: 5532235
    Abstract: Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: July 2, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Efren G. Delos Santos, Xuemei Du, Marvin E. Reich, Aranapakam M. Venkatesan
  • Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
    Patent number: 5516774
    Abstract: Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: May 14, 1996
    Assignee: American Cyanamid Company
    Inventors: Jay D. Albright, Marvin F. Reich, Fuk-Wah Sum, Efren G. Delos Santos