Patents by Inventor Efstathios Karathanasis
Efstathios Karathanasis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230016609Abstract: A system for delivering a therapeutic agent to cell or tissue of a subject includes a mesoporous silica iron oxide nanoparticle with one or more therapeutic agents that are contained in a mesoporous silica layer of the nanoparticle and a remote radiofrequency (RF) energy source for applying RF energy to the nanoparticle effective to release the one or more therapeutic agents from the nanoparticle by mechanical tumbling and/or vibration of the nanoparticle, wherein release of the one or more therapeutic agents not caused by a hyperthermic response of the nanoparticle to the RF energy.Type: ApplicationFiled: March 1, 2022Publication date: January 19, 2023Inventors: Efstathios Karathanasis, Watuthentrige Pubudu M. Peiris, Vindya Perera, Lisa Bauer
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Patent number: 11260127Abstract: A system for delivering a therapeutic agent to cell or tissue of a subject includes a mesoporous silica iron oxide nanoparticle with one or more therapeutic agents that are contained in a mesoporous silica layer of the nanoparticle and a remote radiofrequency (RF) energy source for applying RF energy to the nanoparticle effective to release the one or more therapeutic agents from the nanoparticle by mechanical tumbling and/or vibration of the nanoparticle, wherein release of the one or more therapeutic agents not caused by a hyperthermic response of the nanoparticle to the RF energy.Type: GrantFiled: October 17, 2018Date of Patent: March 1, 2022Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Efstathios Karathanasis, Watuthentrige Pubudu M. Peiris, Vindya Perera, Lisa Bauer
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Patent number: 11065202Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: GrantFiled: December 4, 2018Date of Patent: July 20, 2021Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Efstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Publication number: 20210186875Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: ApplicationFiled: December 4, 2018Publication date: June 24, 2021Inventors: Efstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Publication number: 20210038633Abstract: An immuno-nanoparticle construct for use in therapeutic applications includes a nanocarrier, a stimulator of interferon (IFN) genes (STING) pathway agonist, and a toll-like receptor 4 (TLR4) agonist, wherein the STING pathway agonist and the TLR4 agonist are co-loaded in the nanoparticle carrier.Type: ApplicationFiled: August 10, 2020Publication date: February 11, 2021Inventor: Efstathios Karathanasis
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Patent number: 10729652Abstract: A multi-component nanoconstruct for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: GrantFiled: March 15, 2018Date of Patent: August 4, 2020Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Efstathios Karathanasis, Watuthentrige Pubudu M. Peiris, Elizabeth Doolittle
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Publication number: 20190307687Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: ApplicationFiled: December 4, 2018Publication date: October 10, 2019Inventors: Efstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Publication number: 20190111133Abstract: A system for delivering a therapeutic agent to cell or tissue of a subject includes a mesoporous silica iron oxide nanoparticle with one or more therapeutic agents that are contained in a mesoporous silica layer of the nanoparticle and a remote radiofrequency (RF) energy source for applying RF energy to the nanoparticle effective to release the one or more therapeutic agents from the nanoparticle by mechanical tumbling and/or vibration of the nanoparticle, wherein release of the one or more therapeutic agents not caused by a hyperthermic response of the nanoparticle to the RF energy.Type: ApplicationFiled: October 17, 2018Publication date: April 18, 2019Inventors: Efstathios Karathanasis, Prabhani Atukorale, Wyatt Becicka, Pete Bielecki
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Patent number: 10143653Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: GrantFiled: September 12, 2016Date of Patent: December 4, 2018Assignee: Case Western Reserve UniversityInventors: Efstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Publication number: 20180263910Abstract: A multi-component nanoconstruct for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: ApplicationFiled: March 15, 2018Publication date: September 20, 2018Inventors: Efstathios Karathanasis, Pubudu M. Peiris Watuthentrige, Vindya Perera, Prabhani Atukorale
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Publication number: 20170216206Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: ApplicationFiled: September 12, 2016Publication date: August 3, 2017Inventors: Efstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Patent number: 9439966Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: GrantFiled: October 12, 2012Date of Patent: September 13, 2016Assignee: Case Western Reserve UniversityInventors: Efstathios Karathanasis, Watuthantrige Pubudu M. Peiris, Mark Griswold
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Patent number: 8911708Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: GrantFiled: December 17, 2012Date of Patent: December 16, 2014Assignee: Marval Pharma, Inc.Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Efstathios Karathanasis, Russell M. Lebovitz
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Publication number: 20140248339Abstract: A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.Type: ApplicationFiled: October 12, 2012Publication date: September 4, 2014Applicant: Case Western Reserve UniversityInventors: Efstathios Karathanasis, Pubudu M. Peiris, Mark Griswold
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Patent number: 8642013Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: GrantFiled: December 5, 2008Date of Patent: February 4, 2014Inventors: Ananth Annapragada, Ravi Bellamkonda, Efstathios Karathanasis, Russell M. Lebovitz
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Publication number: 20130189187Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: ApplicationFiled: December 17, 2012Publication date: July 25, 2013Inventors: Ananth Annapragada, Ravi V. Bellamkonda, Efstathios Karathanasis, Russell M. Lebovitz
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Patent number: 8357351Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: GrantFiled: January 22, 2009Date of Patent: January 22, 2013Inventors: Ananth Annapragada, Efstathios Karathanasis, Ravi V. Bellamkonda, Russell M. Lebovitz
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Publication number: 20100202974Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: ApplicationFiled: December 5, 2008Publication date: August 12, 2010Inventors: Ananth Annapragada, Ravi Bellamkonda, Efstathios Karathanasis, Russell M. Lobovitz
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Publication number: 20090263326Abstract: Compositions and methods are disclosed for evaluating a subject's vasculature integrity, for differentiating between a malignant lesion and a benign lesion, for evaluating the accessibility of a tumor to nano-sized therapeutics, for treating tumors, and for live or real time monitoring of a nano-probe's biodistribution.Type: ApplicationFiled: January 22, 2009Publication date: October 22, 2009Applicant: Marval BioSciences, Inc.Inventors: Efstathios Karathanasis, Russell M. Lebovitz, Ananth Annapragada, Ravi V. Bellamkonda