Patents by Inventor EFTHYMIOS KOUTRIS

EFTHYMIOS KOUTRIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190209465
    Abstract: The present invention relates to the field of drug delivery and, particularly, to alternative processes for preparing ophthalmic compositions of Brinzolamide or pharmaceutical acceptable salts thereof.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 11, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, AMALIA DIAKIDOU, ANDREAS KAKOURIS, RUMIT SHAH
  • Publication number: 20190151293
    Abstract: The present invention relates to a stable pharmaceutical formulation of solid dosage forms for oral administration comprising a therapeutically effective amount of a non-purine selective inhibitor of xanthine oxidase, in particular Febuxostat and an effective amount of an alkalizing agent. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 26, 2017
    Publication date: May 23, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, CHRISTINA KIZIRIDI, MORFIS ABATZIS, KATERINA TSILIOUKA
  • Publication number: 20190117562
    Abstract: The present invention relates to a preservative-free ophthalmic composition for the reduction of elevated intraocular pressure containing Latanoprost or a combination of Latanoprost and Timolol and to a process for preparing such compositions.
    Type: Application
    Filed: April 11, 2017
    Publication date: April 25, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: Evangelos KARAVAS, Efthymios KOUTRIS, Vasiliki SAMARA, Ioanna KOUTRI, Anastasia KALASKANI, Andreas KAKOURIS, Manolis FOUSTERIS
  • Publication number: 20180214381
    Abstract: The present invention relates to controlled release pharmaceutical formulations comprising an atypical antipsychotic agent such as Paliperidone or pharmaceutical acceptable salt thereof in the form of a multi-layer tablet that provides zero order drug release. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: July 7, 2016
    Publication date: August 2, 2018
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, MORFIS ABATZIS, CHRISTINA KIZIRIDI
  • Patent number: 9943484
    Abstract: The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: April 17, 2018
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthymios Koutris, Sotiria Haitidou, Theofanis Mantourlias, Georgia Papanikolaou
  • Patent number: 9943483
    Abstract: A novel process for the preparation of a long acting injectable composition based on biodegradable poly(D,L-lactide-co-glycolide) microspheres comprising peptide active pharmaceutical ingredients.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: April 17, 2018
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthymios Koutris, Katerina Minioti, Sotiria Chaitidou, Georgia Papanikolaou, Theofanis Mantourlias
  • Publication number: 20170281547
    Abstract: A novel process for the preparation of a long acting injectable composition based on biodegradable poly(D,L-lactide-co-glycolide) microspheres comprising peptide active pharmaceutical ingredients.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 5, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, KATERINA MINIOTI, SOTIRIA CHAITIDOU, GEORGIA PAPANIKOLAOU, THEOFANIS MANTOURLIAS
  • Publication number: 20170202844
    Abstract: The present invention relates to a pediatric chewable tablet comprising a therapeutically effective amount of an anti-viral agent or pharmaceutical acceptable salt or derivative thereof, in particular Valaciclovir in complex with an ion exchange resin in a specific ratio in order to obtain a palatable and child-friendly product. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 20, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, MANOLIS FOUSTERIS
  • Publication number: 20170202843
    Abstract: The present invention relates to a pediatric powder for reconstitution as suspension for oral administration comprising a therapeutically effective amount of an antiviral agent or pharmaceutical acceptable salt or derivative thereof, in particular Valaciclovir in complex with an ion exchange resin in a specific ratio in order to obtain a palatable and child-friendly product. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 20, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, MANOLIS FOUSTERIS
  • Publication number: 20170202804
    Abstract: The present invention relates to water dispersible mini-tablets of Enalapril or a pharmaceutically acceptable salt thereof for use in the treatment of hypertension in a pediatric formulation. The pediatric formulation is defined as 0 to 18 years of age. The present invention also provides a method of manufacturing of such dosage form.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 20, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, LOUIZA KONSTANTI
  • Publication number: 20170165315
    Abstract: The present invention relates to an oral applicable therapeutic dosage form, in particular an orodispersible film comprising Enalapril or pharmaceutically acceptable salts thereof for use in the treatment of hypertension in a pediatric population. The pediatric population is defined from 1 to 18 years of age. The present invention also provides a method of manufacturing of such a dosage form.
    Type: Application
    Filed: June 19, 2015
    Publication date: June 15, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, LOUIZA KONSTANTI
  • Publication number: 20160143851
    Abstract: The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 26, 2016
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, SOTIRIA HAITIDOU, THEOFANIS MANTOURLIAS, GEORGIA PAPANIKOLAOU