Patents by Inventor Egbert Müller
Egbert Müller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200181287Abstract: The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies.Type: ApplicationFiled: October 14, 2019Publication date: June 11, 2020Inventors: Nicolas FOUQUE, Jean-Francois DEPOISIER, Keith WILSON, Judith VAJDA, Egbert MUELLER, Romain DABRE
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Patent number: 10457749Abstract: The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies.Type: GrantFiled: March 14, 2016Date of Patent: October 29, 2019Assignee: NovImmune SAInventors: Nicolas Fouque, Jean François Depoisier, Keith Wilson, Judith Vajda, Egbert Müller, Romain Dabre
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Publication number: 20160264685Abstract: The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies.Type: ApplicationFiled: March 14, 2016Publication date: September 15, 2016Inventors: Nicolas Fouque, Jean François Depoisier, Keith Wilson, Judith Vajda, Egbert Müller, Romain Dabre
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Publication number: 20120160771Abstract: A separating material formed by a solid substrate having a substrate surface, primary or secondary amines coupled to the substrate surface, and a graft polymer formed on the substrate by covalently coupling the primary or secondary amines with a thermally labile radical initiator and subsequently contacting the substrate surface with a solution of one or more polymerizable monomers. Methods for the extracorporeal treatment of blood, blood plasma or blood serum employing the separating material, for affinity adsorption, ion-exchange adsorption, hydrophobic adsorption, or hydrophilic adsorption employing the separating material, and a separating column employing the separating material are also disclosed.Type: ApplicationFiled: February 16, 2012Publication date: June 28, 2012Applicant: GAMBRO LUNDIA ABInventors: Markus Storr, Egbert Müller, Wolfgang Freudemann
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Patent number: 8142844Abstract: The present invention provides a separating material producable by a) providing a solid substrate, having amino-functional groups coupled to the substrate surface, b) covalently coupling of the amino-functional groups with a thermally labile radical initiator, c) contacting the substrate surface with a solution of polymerizable monomers under conditions, where thermally initiated graft copolymerization of the monomers takes place, to form a structure of adjacent functional polymer chains on the surface of the substrate.Type: GrantFiled: August 30, 2004Date of Patent: March 27, 2012Assignee: Gambro Lundia ABInventors: Markus Storr, Egbert Müller, Wolfgang Freudemann
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Patent number: 7235199Abstract: The invention relates to a process for the production of chromatography columns or capillaries containing sorbents of monolithic mouldings which can remain directly in their gelation mould after production. This is achieved by the process according to the invention, in which the gelation mould is repeatedly filled with the monomer sol.Type: GrantFiled: May 16, 2001Date of Patent: June 26, 2007Assignee: Merck Patent GmbHInventors: Dieter Lubda, Egbert Mueller
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Patent number: 6478967Abstract: The invention relates to methods for separating biological contaminants (viruses, nucleic acids and/or endotoxins) from biological products, or for reducing the content of such biological contaminants in said biological products. The sample (biological product) to be purified is treated with an anion exchanger membrane. Said anion exchanger membrane is obtained by reacting a polyamide with an aminoreactive compound which is capable of polymerisation. This is followed by polymerisation with monomers which contain cationic groups or into which cationic groups can be introduced in a reaction analogous to polymerisation.Type: GrantFiled: December 20, 2000Date of Patent: November 12, 2002Assignee: Merck Patent Gesellschaft MITInventor: Egbert Müller
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Patent number: 6465600Abstract: The present invention relates to a process for removing an initiator of cerium (IV) salt from a graft product. The process may include washing the graft product with a mineral acid solution comprising ascorbic acid.Type: GrantFiled: February 5, 2001Date of Patent: October 15, 2002Assignee: Merck Patent Geselleschaft mit beschranhkter HaftungInventors: Lothar Britsch, Egbert Müller, Josef-Stefan Stöhr
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Patent number: 6383584Abstract: The present invention relates to an azlactone-derivatized polyamide shaped article made by reacting at least one polyamide with a solution comprising an aza-bicyclo compound and a vinylazlactone derivative of the formula I wherein R1, R2, R3, R4, and R5 are defined herein.Type: GrantFiled: January 6, 1999Date of Patent: May 7, 2002Assignee: Merck Patent Geselleschaft mit beschrankterInventors: Egbert Müller, Anja Seiler
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Patent number: 6149994Abstract: The invention relates to polyamides which are derivatized with polymerizable double bonds and are obtainable by reaction of the amino groups of the polyamide with an amino-reactive compound which contains a polymerizable double bond, or by reaction of the carboxyl groups of the polyamide with a carboxyl group-reactive compound which contains a polymerizable double bond. Examples of amino-reactive compounds which contain a polymerizable double bond are the anhydrides of ethylenically unsaturated carboxylic acids, such as acrylic acid chloride or anhydride, methacrylic acid chloride or anhydride, or vinylazlactone derivatives. An example of a carboxyl group-reactive compound is allylamine.These derivatized polyamides can be converted into polymer-modified base polymers (typically block polymers) with improved properties. These polymer-modified base polymers are suitable as adsorbents for chromatography and as carriers for enzymes.Type: GrantFiled: November 23, 1998Date of Patent: November 21, 2000Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Egbert Mueller, Hans-Dieter Harders, Dieter Lubda