Patents by Inventor Egbert Wehinger

Egbert Wehinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5955482
    Abstract: The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: September 21, 1999
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Otto Behner, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Egbert Wehinger, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
  • Patent number: 5665741
    Abstract: The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: September 9, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Urbahns, Otto Behner, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Egbert Wehinger, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
  • Patent number: 4988717
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: January 29, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bosseret, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislav Kazda
  • Patent number: 4849433
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: July 18, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bossert, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislav Kazda
  • Patent number: 4798840
    Abstract: Hypotensive long-acting 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclic,R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the usual definitions in such compounds,R.sup.6 represents hydrogen or a lower alkyl radical or the trifluoromethyl group,R.sup.7 and R.sup.8 each denote a hydrogen atom or a fluorine atom,n.gtoreq.1 andm.gtoreq.0, and the sum of n and m must be a least 4, andX represents a single bond, an oxygen atom or the group --N(alkyl)--O.sub.2 S--,or pharmacologically acceptable acid addition salts thereof.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: January 17, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Andreas Knorr, Stanislav Kazda
  • Patent number: 4705794
    Abstract: Pyridinecarboxylic acid esters of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,R.sup.1 and R.sup.2 are hydrogen, alkyl, aryl, aralkyl, acyloxyalkyl or hydroxyalkyl, or R.sup.1 with X forms a carbonyl-containing heterocyclic ring,X is --CN, --CO--R.sup.4, --COOR.sup.5 or --SO.sub.2 R.sup.6,R.sup.4, R.sup.5 and R.sup.6 are various optionally substituted radicals, andR.sup.3 is different from R.sup.5 and is a substituted or interrupted hydrocarbon radical,or pharmaceutically acceptable salts thereof control the otherwise negative effects of ischaemia and/or hypoxia.
    Type: Grant
    Filed: February 28, 1983
    Date of Patent: November 10, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Ulrich Benz
  • Patent number: 4703119
    Type: Grant
    Filed: June 4, 1985
    Date of Patent: October 27, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer
  • Patent number: 4680305
    Abstract: A method of treating a patient suffering from asthma which comprises administering to such patient an asthma-relieving amount of a 5-sulphonyl-1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 is aryl having 6 or 10 C atoms, optionally substituted by 1 to 3 identical or different substituents from the group: halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, alkoxycarbonyl (up to 4 C atoms), carboxyl, alkoxy (up to 4 C atoms) or straight-chain or branched alkyl having up to 4 C atoms,or is heteroaryl,R.sup.
    Type: Grant
    Filed: January 8, 1986
    Date of Patent: July 14, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Robertson Towart
  • Patent number: 4675329
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: June 23, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Andreas Knorr, Kurt Stoepel, Arend Heise
  • Patent number: 4622332
    Abstract: Compounds of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,R.sup.1 is a hydrocarbon radical which is optionally interrupted by 1 oxygen atom in the chain, and/or which is optionally substituted,R.sup.4 is an aliphatic hydrocarbon radical having 7 to 14 carbon atoms, which is optionally interrupted by one oxygen atom and/or which is optionally substituted,R.sup.2 and R.sup.3 each independently is hydrogen, an alkyl radical, an aryl radical or an aralkyl radical, or, for the case where one of the substituents R.sup.2 or R.sup.3 has the above-mentioned meaning, the other is hydroxymethyl, acetoxymethyl or amino, andX is N-R.sup.5, wherein R.sup.5 is hydrogen, an alkyl radical which is optionally interrupted by an oxygen atom, a morpholinoalkyl radical, an aryl radical or an aralkyl radical orX is an oxygen atom, when one of the radicals R.sup.2 or R.sup.3 denotes an amino group,or pharmaceutically acceptable acid addition salts thereof, exhibit hypotensive activity.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: November 11, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Andreas Knorr
  • Patent number: 4621082
    Abstract: Pyridopyrimidines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,exhibit circulation active properties, especially renal vasodilating and diuretic action.
    Type: Grant
    Filed: January 7, 1986
    Date of Patent: November 4, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Egbert Wehinger, Bernward Garthoff, Stanislav Kazda
  • Patent number: 4568681
    Abstract: 1,2,3,4-Tetrahydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,R.sup.2 is an organic radical,X is a nitrile or ester,R.sup.3 and R.sup.5 are identical or different and each represent hydrogen, a straight-chain or branched or salts thereof with physiologically tolerated acids are antihypertensives.
    Type: Grant
    Filed: October 3, 1983
    Date of Patent: February 4, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Stanislav Kazda, Andreas Knorr
  • Patent number: 4565824
    Abstract: Dihydropyridines of the formula ##STR1## in which R is aryl or heterocyclic,R.sup.1, R.sup.2 and R.sup.3 each is hydrogen or various organic radicals,Y is oxygen, or optionally substituted --NH--,Z is --O--NO.sub.2 or --O--NO,X is --COR.sup.4, --COOR.sup.5 or --CO--Y--A--Z,R.sup.4 is alkyl, phenyl, benzyl or an amino radical, andR.sup.5 is an organic radical,or pharmaceutically acceptable acid addition salts thereof, exhibit circulation active properties, e.g. they can be used as antihypertensives, as peripheral and cerebral vasodilators and as coronary therapeutics.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: January 21, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Stanislav Kazda, Andreas Knorr
  • Patent number: 4559350
    Abstract: 1,2,3,4-Tetrahydropyridines of the formula ##STR1## in which R.sup.1 is optionally substituted aryl or heterocyclic,R.sup.2 is an organic radical, X is a nitrile or an esterR.sup.3 and R.sup.5 are identical or different and each represent hydrogen, a straight-chain or branched or salts thereof with physiologically tolerated acids are antihypertensives.
    Type: Grant
    Filed: August 24, 1984
    Date of Patent: December 17, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Stanislav Kazda, Andreas Knorr
  • Patent number: 4551467
    Abstract: The invention relates to 1,4-dihydropyridines as well as methods for the preparation of said 1,4-dihydropyridines and compositions contained therein. The invention also includes the use of said compounds and compositions for influencing circulation.
    Type: Grant
    Filed: October 11, 1979
    Date of Patent: November 5, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert, Wulf Vater, Kurt Stoepel
  • Patent number: 4532248
    Abstract: 1,4-Dihydropyridines of the formula ##STR1## in which n is 0,1 or 2, andR.sup.1 to R.sup.7 can have a wide variety of meanings, which possess inotropic action, and many of which are new, are useful in increasing the influx of Ca.sup.++ into cells, particularly in combatting coronary and vascular diseases, hypertension swelling in the mucous membranes and diseases involving increased blood sugar or an incorrect salt and fluid balance.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: July 30, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Franckowiak, Horst Boshagen, Friedrich Bossert, Siegfried Goldmann, Horst Meyer, Egbert Wehinger, Jurgen Stoltefuss, Matthias Schramm, Gunter Thomas, Robertson Towart
  • Patent number: 4510310
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: April 9, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bossert, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislay Kazda
  • Patent number: 4497821
    Abstract: A method of controlling damage to the central nervous system of a patient which comprises administering to such patient a central nervous system-controlling effective amount of a pyridine derivative of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,R.sup.1 and R.sup.2 are hydrogen or various organic radicals,X and Y are CN, --CO--R.sup.3, --COOR.sup.4 or --SO.sub.2 R.sup.5, or form with R.sup.1 or R.sup.2 a carbonyl-containing ring,R.sup.3 is an alkyl, aryl or aralkyl radical,R.sup.4 is hydrogen or an organic radical, andR.sup.5 is an optionally substituted alkyl or phenyl radical,or a salt thereof.
    Type: Grant
    Filed: February 28, 1983
    Date of Patent: February 5, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Ulrich Benz
  • Patent number: 4483985
    Abstract: The invention relates to a process for the production of 1,4-dihydropyridinecarboxylic acid compounds which involves hydrolysis, under alkaline conditions and in a temperature range from 10.degree. to 100.degree. C., of an ester group which contains an electron-attracting group. The invention also includes novel compounds made according to the invention as well as compositions containing said novel compounds. Also included in the invention are methods for the use of said compounds and compositions. The compounds obtained according to the process of the invention are useful because of their circulation-influencing action and are also useful as intermediates for the preparation of compounds having circulation-influencing action.
    Type: Grant
    Filed: January 19, 1981
    Date of Patent: November 20, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Friedrich Bossert
  • Patent number: 4360520
    Abstract: The invention includes new 1,4-dihydropyridazine compounds, compositions containing said 1,4-dihydropyridazine compounds and methods for the use of said compounds and compositions. Also included in the invention are methods for preparing the new 1,4-dihydropyridazine compounds.
    Type: Grant
    Filed: September 11, 1978
    Date of Patent: November 23, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Meyer, Gerhard Franckowiak, Friedrich Bossert, Arend Heise, Stanislav Kazda, Kurt Stoepel, Robertson Towart, Egbert Wehinger