Patents by Inventor Eggert Brekkan

Eggert Brekkan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chelator and use thereof
    Patent number: 10662261
    Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 26, 2020
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Mattias Algotsson, Lars C. Andersson, Eggert Brekkan, Lee Hedemyr, Jean-Luc Maloisel, Ronnie Palmgren
  • Novel Chelator and Use Thereof
    Publication number: 20180223003
    Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.
    Type: Application
    Filed: March 27, 2018
    Publication date: August 9, 2018
    Inventors: Mattias Algotsson, Lars C. Andersson, Eggert Brekkan, Lee Hedemyr, Jean-Luc Maloisel, Ronnie Palmgren
  • Chelator and use thereof
    Patent number: 9944722
    Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.
    Type: Grant
    Filed: May 30, 2011
    Date of Patent: April 17, 2018
    Assignee: GE Healthcare Bioprocess R&D AB
    Inventors: Mattias Algotsson, Lars C. Andersson, Eggert Brekkan, Lee Hedemyr, Jean-Luc Maloisel, Ronnie Palmgren
  • Method for purification of cleaved pro-insulin
    Patent number: 9409967
    Abstract: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: August 9, 2016
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Eggert Brekkan, Kjell Eriksson, Bo-Lennart Johansson, Jamil Shanagar
  • METHOD FOR PURIFICATION OF CLEAVED PRO-INSULIN
    Publication number: 20140243498
    Abstract: The present invention is within the field of biomolecule purification. More closely the invention relates to chromatographic purification of insulin using a specific kind of shell beads having an inner core and an outer functionalized layer. The method enables purification at high flow rates and high purity, over 90%.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 28, 2014
    Inventors: Eggert Brekkan, Kjell Eriksson, Bo-Lennart Johansson, Jamil Shanagar
  • NOVEL CHELATOR AND USE THEREOF
    Publication number: 20130072638
    Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.
    Type: Application
    Filed: May 30, 2011
    Publication date: March 21, 2013
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Mattias Algotsson, Lars C. Andersson, Eggert Brekkan, Lee Hedemyr, Jean-Luc Maloisel, Ronnie Palmgren
  • SEPARATION MATRICES
    Publication number: 20120202976
    Abstract: The present invention relates to separation matrices comprising base matrices with first ligands comprising hydrophobic functions covalently bound to said base matrices and with extenders covalently bound to said base matrices, said extenders comprising second ion exchange ligands.
    Type: Application
    Filed: October 8, 2010
    Publication date: August 9, 2012
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Andreas Axen, Eggert Brekkan, Gunilla Edgren, Gunnar Malmquist