Patents by Inventor Egon Kárpáti
Egon Kárpáti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4769373Abstract: The invention relates to new anti-arrythmic azabicyclo[3.3.1]nonanes of the general formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are C.sub.1-4 alkyl groups which are the same or different, or one of them is a benzyl group and the others are C.sub.1-4 alkyl groups, andR.sup.4 is a hydroxy group, or an etherified hydroxy group of the formula --OR.sup.5, or an esterified hydroxy group of the formula --OOCR.sup.6, in which the esterifying groupR.sup.5 is a phenyl or benzyl group which optionally each can have a trihalomethyl substituent or one or more halogen or C.sub.1-4 substituents, or is a diphenyl or benzhydryl group, and the esterifying groupR.sup.6 is a C.sub.1-8 alkyl or a C.sub.3-6 cycloalkyl group, or a phenyl or benzyl group which optionally each can have a halo-substituent or one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro or phenyl substituents, or is an optionally halogenated or hydrogenated naphthyl group, or a cinnamyl group optionally substituted by a halogen atom or C.sub.Type: GrantFiled: November 26, 1984Date of Patent: September 6, 1988Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Karoly Nador, Gabor Kraiss, Margit Paroczay, Egon Karpati, Laszlo Szporny
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Patent number: 4753949Abstract: The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), ##STR1## wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts.The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), ##STR2## wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt.The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong .alpha.-adrenerg blocking and calcium-antagonistic action.Type: GrantFiled: June 23, 1986Date of Patent: June 28, 1988Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Gabor Megyeri, Tibor Keve, Bala Stefko, Erik Bogsch, Janos Galambos, Anna Kassi nee Zieger, Ferenc Trischler, Eva Palosi, Dora Groo, Egon Karpati, Zsolt Szombathelyi, Laszlo Szporny, Bela Kiss, Istvan Laszlovszky, Erzsebet Lapis
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Patent number: 4725617Abstract: The present invention relates to a compound of the formula (I) ##STR1## wherein R.sup.1 stands for methyl or a group of the formula R.sup.3 --NH--(CH.sub.2).sub.4 --wherein R.sup.3 is hydrogen or a protective group being compatible with the peptide bond,R.sup.2 represents hydrogen, a protective group being compatible with the peptide bond or a cation derived from an organic or inorganic basethe pharmaceutically acceptable salts and diastereomers thereof.The compounds of the invention are useful for inhibiting the effect of the angiotensin converting ensime and they can be used in the therapy as blood pressure reducing agents and for the treatment of cardiac failure and glaucoma.Type: GrantFiled: February 10, 1986Date of Patent: February 16, 1988Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Tamas Fodor, Laszlo Dobay, Janos Fischer, Bela Stefko, Bela Kiss, Zsolt Szombathelyi, Egon Karpati, Istvan Laszlovszky, Laszlo Szporny
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Patent number: 4681887Abstract: The invention relates to pharmaceutical compositions with a neuroleptic action as well as to a process for preparing these compositions.The active ingredients of the compositions of the invention are 2-halo-6-methyl-9-ergolene derivatives of the formula (I), ##STR1## wherein X represents a chlorine, bromine or iodine atom as well as their acid addition salts.The compositions of the invention contain an effective dose of compound of the general formula (I) or an acid addition salt thereof.Type: GrantFiled: June 23, 1986Date of Patent: July 21, 1987Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Gabor Megyeri, Tibor Keve, Bela Stefko, Erik Bogsch, Janos Galambos, Anna Kassainee Zieger, Ferenc Trischler, Eva Palosi, Dora Groo, Egon Karpati, Zsolt Szombathelyi, Laszlo Szporny, Bela Kiss, Istvan Laszlovszky, Erzsebet Lapis
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Patent number: 4672054Abstract: The invention relates to octapeptides of the formulaX-Arg-Val-Tyr-Y-His-Pro-W (I)whereinX is a sarcosyl, lactoyl or hydroxyacetyl radical,Y is cyclopentylglycyl or cyclohexylglycyl, andW is an alanine radical or lactic acid radicalhaving angiotensine-II antagonistic activity.Type: GrantFiled: August 1, 1985Date of Patent: June 9, 1987Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Olga Nyeki nee Kuprina, Lajos Kisfaludy, Katalin Szeberenyi nee Szalay, Gabor Makara, Bertalan Varga, Egon Karpati, Laszlo Szporny
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Patent number: 4614824Abstract: The invention relates to new racemic and optically active apovincaminic acid derivatives of the general formula (I) ##STR1## wherein A is hydroxyl, halogen or a group --O--(CH.sub.2).sub.n --OR.sup.1 or --OMe, in whichR.sup.1 is alkyl having from one to 6 carbon atoms,n is an integer between 2 and 6,Me is an alkali metal,R.sup.2 stands for an alkyl group having from one to 6 carbon atoms, which may be identical with or different from R.sup.1,and the hydrogen in the 3-position and the R.sup.2 group have an .alpha.,.alpha.- and/or .beta.,.beta.- or .alpha.,.beta.- and/or .beta.,.alpha.-configuration, and pharmaceutically acceptable acid addition salts thereof, which are pharmaceutically active, e.g. show antihypoxial activity or are potent peripheral vasodilators. Their preparation and pharmaceutical composition containing them are also within the scope of the invention.Type: GrantFiled: July 11, 1985Date of Patent: September 30, 1986Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Janos Kreidl, Laszlo Czibula, Gyorgy Visky, Maria Farkas nee Kirjak, Judit Meszaros nee Brill, Dora Groo, Eva Palosi, Egon Karpati, Laszlo Szporny
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Patent number: 4549020Abstract: The invention relates to optically active or racemic eburnane-oxime ethers of the formulae (Ia) and/or ##STR1## wherein R represents an alkyl group having 1 or 2 carbon atoms,R.sup.2 represents an alkyl group having 1 to 6 carbon atoms,and the configuration of the hydrogen in the 3-position and the R.sup.2 group is .alpha.,.alpha. and/or .beta.,.beta. or .alpha.,.beta. and/or .beta.,.alpha. and acid addition salts thereof.The new compounds show valuable pharmaceutical activities, thus are potent CNS-tranquillants, smooth muscle relaxants, sedatives and hypnotic agents, and can therefore be employed as active ingredients of pharmaceutical compositions, which are also within the scope of the present invention.Type: GrantFiled: June 27, 1983Date of Patent: October 22, 1985Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Janos Sapi, Maria Zajer nee Balazs, Bela Kiss, Elemer Ezer, Egon Karpati, Laszlo Szporny
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Patent number: 4530964Abstract: The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation.Type: GrantFiled: March 24, 1983Date of Patent: July 23, 1985Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Raymund Machovich, Miklos Nagy, Judit Gyorgyi nee Edelenyi, Istvan Horvath, Miklos Low, Katalin Csomor, Egon Karpati, Laszlo Szporny, Lajos Kisfaludy
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Patent number: 4481204Abstract: The invention relates to racemic or optically active E-homo-eburnane derivatives of the formula /I/, ##STR1## wherein R.sup.1 and R.sup.2 independently represent an alkyl group having 1 to 6 carbon atoms,and acid addition salts thereof.The new compounds are pharmaceutically active, for example their certain representatives, in particular from the cis-series, show antidepressive activity, while others, especially the compounds of the trans-series, are potent anthypoxial agents. The compounds of the formula /I/ and pharmaceutically acceptable acid addition salts thereof can therefore be employed as active ingredients of pharmaceutical compositions.Type: GrantFiled: June 29, 1983Date of Patent: November 6, 1984Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Janos Sapi, Eva Palosi, Egon Karpati, Laszlo Szporny
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Patent number: 4456607Abstract: New salts of the formula XIIIa and XIIIb are disclosed ##STR1## wherein R.sup.2, R.sup.3 and R.sup.5 are each C.sub.1 to C.sub.6 alkyl and A.sup.- is an anion of a pharmaceutically acceptable acid. Furthermore new compounds of the formula XIVa and XIVb are disclosed: ##STR2## wherein R.sup.2 and R.sup.3 are as defined above. The new salts and compounds are intermediates in the preparation of 10-bromo-vincaminic acid esters. In addition the new salts and compounds have the ability to increase blood circulation and to decrease blood flow resistance in an animal subject while at the same time maintaining a steady pulse rate and blood pressure.Type: GrantFiled: June 2, 1981Date of Patent: June 26, 1984Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Lajos Dancsi, Tibor Keve, Egon Karpati, Laszlo Szporny
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Patent number: 4451473Abstract: New bicyclic compounds of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.2 each represent a C.sub.1-6 alkyl group, andR.sup.3 is an etherified hydroxy group of the formula --CR.sup.4, wherein R.sup.4 is benzyl group, benzhydryl group or a phenyl group bearing optionally a phenyl or a trihalomethyl substituent or one or more halogen substituent(s), orR.sup.3 is an esterified hydroxy group of the formula --OCO--R.sup.5, which representsa phenyl-(C.sub.1-5 alkyl)-carbonyloxy group,a cinnamoyloxy group having optionally a halogen or one or more C.sub.1-4 alkoxy substituent(s),a benzoyloxy group having optionally a C.sub.1-4 alkyl, phenyl or trihalomethyl substituent or one or more C.sub.Type: GrantFiled: July 16, 1982Date of Patent: May 29, 1984Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Karoly Nador, Gabor Kraiss, Katalin Sinko, Margit Paroczai, Egon Karpati, Laszlo Szporny
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Patent number: 4432982Abstract: The invention relates to new polycyclic compounds substituted on the A-ring. More particularly, the invention concerns new polycyclic compounds of the formula (I) ##STR1## wherein R.sup.1 is methoxy or halogen andR.sup.2 is hydrogen; orR.sup.1 is hydrogen andR.sup.2 is halogen and acid addition salts thereof.Type: GrantFiled: February 4, 1982Date of Patent: February 21, 1984Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Mari Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy
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Patent number: 4428877Abstract: A novel process for preparing 10-bromo-vincaminic acid esters and homologous compounds of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each stand for a C.sub.1-6 alkyl group is disclosed.All the intermediate products are new and exhibit valuable therapeutical effect on the blood circulation.Type: GrantFiled: February 13, 1981Date of Patent: January 31, 1984Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Lajos Dancsi, Tibor Keve, Egon Karpati, Laszlo Szporny
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Patent number: 4424223Abstract: The invention relates to the new 17,18-dehydro-apovincaminol-3',4',5'-trimethoxy-benzoate of formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of these new compounds. Still another aspect of the invention is a pharmaceutical composition for treating psoriasis.Type: GrantFiled: February 4, 1982Date of Patent: January 3, 1984Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Tibor Keve, Bela Zsadon, Gyorgy Fekete, Csaba Lorincz, Janos Galambos, Maria Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy
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Patent number: 4424224Abstract: The invention relates to the new apovincaminol-3',4',5'-trimethoxy-benzoate and acid addition salts thereof.The new compound may be prepared by reacting apovincaminol or an acid addition salt thereof with 3,4,5-trimethoxy benzoic acid or a reactive derivative thereof capable of acylation and if desired converting the compound thus obtained into an acid addition salt.The new compound of the present invention can be used in therapy in the treatment of skin diseases attached to pathological cell proliferation and in the propylaxis of such diseases.Type: GrantFiled: February 4, 1982Date of Patent: January 3, 1984Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Zsuzsanna Gyulai, Maria Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy
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Patent number: 4419359Abstract: The present invention relates to the compounds of the Formulae 1a and 1b and pharmaceutically acceptable acid addition salts thereof.The new 9-nitro-apovincaminol-3',4',5'-trimethoxybenzoate of the Formula 1a ##STR1## and the 11-nitro-apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 1b ##STR2## and pharmaceutically acceptable acid addition salts thereof can be prepared by nitrating the apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 11, ##STR3## if desired separating the mixture of the compounds of the Formulae 1a and 1b thus obtained into its components, if desired converting a compound of the Formula 1a or 1b thus obtained into pharmaceutically acceptable acid addition salts thereof.The new compounds of the present invention can be used in therapy in the treatment of psoriasis.Type: GrantFiled: February 4, 1982Date of Patent: December 6, 1983Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Tibor Keve, Gyorgy Fekete, Csaba Lorincz, Janos Galambos, Bela Zsadon, Maria Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy
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Patent number: 4388304Abstract: New octapeptides of the general formula (I),X--Arg--Val--Tyr--Ile--His--Pro--Y--OA (I)whereinX stands for the acyl group of an N-methylamino acid or the acyl group of an aliphatic .alpha.-hydroxy- or .alpha.-aminooxycarboxylic acid,Y is the residue of an aliphatic amino acid, andA is a C.sub.1-5 alkyl group, are prepared so that the protecting groups of a protected octapeptide derivative of the general formula (II),B--X--Arg(C)--Val--Tyr(D)--Ile--His(E)--Pro--Y--OA (II)whereinB is a group removable by acidolysis or catalytic hydrogenation,C is a group for the temporary protection of the guanidino group on the Arg moiety,D is a group for the temporary protection of the aromatic hydroxy group on the Tyr moiety,E is a group for the temporary protection of the imidazole group on the His moiety, andA, X and Y are as defined above,are removed either stepwise or in a single step. If desired, a compound of the general formula (I) is converted into its acid addition salt or pharmaceutically acceptable complex.Type: GrantFiled: January 14, 1981Date of Patent: June 14, 1983Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Olga Nyeki, Lajos Kisfaludy, Egon Karpati, Laszlo Szporny
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Patent number: 4330532Abstract: New angiotensin-II analogues of the general formula (I),X-Arg-Val-Tyr-Ile-His-Pro-Y-OA (I)whereinX stands for the acyl group of an N-methylamino acid, or the acyl group of an aliphatic .alpha.-aminooxy- or .alpha.-hydroxycarboxylic acid,Y is the residue of an aliphatic .alpha.-hydroxycarboxylic acid, andA is hydrogen or a C.sub.Type: GrantFiled: January 6, 1981Date of Patent: May 18, 1982Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Olga Nyeki, Lajos Kisfaludy, Egon Karpati, Laszlo Szporny
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Patent number: 4329350Abstract: Compounds of the formula: ##STR1## wherein R is alkyl having 1 to 6 carbon atoms;A is substituted or unsubstituted alkyl having 1 to 6 carbon atoms, aralkyl having 7 to 16 carbon atoms wherein the alkyl or aralkyl groups are unbranched in the 1-position or an acyl group derived from an aliphatic or aromatic carboxylic acid;B is hydrogen; orA and B together form an optionally substituted alkylidene having 2 to 8 carbon atoms or an aralkylidene group having 7 to 18 carbon atoms where the alkylidene and aralkylidene groups are unbranched in the 1-position or pharmaceutically acceptable salts thereof are disclosed. The compounds have vasodilating properties.Type: GrantFiled: May 21, 1979Date of Patent: May 11, 1982Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Csaba Szantay, Lajos Szabo, Gyorgy Kalaus, Egon Karpati, Laszlo Szporny
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Patent number: 4328231Abstract: Skin diseases such as psoriasis in a human patient can be treated by topically or parenterally administering a dermatological composition containing a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen andR.sub.2 is the group --COOCH.sub.3, --CONH.sub.2 or --CONHNH.sub.2 ; orR.sub.1 is methoxy andR.sub.Type: GrantFiled: July 25, 1980Date of Patent: May 4, 1982Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Maria Zajer nee Balazs, Lilla Forgach, Egon Karpati, Arpad Kiraly, Gyongyver Kiraly nee Soos, Laszlo Szporny, Bela Rosdy