Abstract: A device and method for targeting multiple sites of nervous tissue includes an outer elongated element (22), and inner elongated element (12), and multiple micro-wire electrodes (30) partially attached to the inner elongated element. The outer elongated element and inner elongated element are movable with respect to one another, wherein in one configuration the multiple micro-wire electrodes are positioned within the outer elongated element and in a another configuration the multiple micro-wire electrodes are positioned partially outside of the outer elongated element. Multiple micro-wire electrodes may maintain various configurations.

Abstract: A neuronal phase-locked loop (NPLL) that can decode temporally-encoded information and convert it to a rate code is based on an algorithm similar to that of the electronic PLL, but is a stochastic device, implemented by neural networks (real or simulated). The simplest embodiment of the NPLL includes a phase detector (that is, a neuronal-plausible version of an ideal coincidence detector) and a controllable local oscillator that are connected in a negative feedback loop. The phase detector compares the firing times of the local oscillator and the input and provides an output whose firing rate is monotonically related to the time difference. The output rate is fed back to the local oscillator and forces it to phase-lock to the input. Every temporal interval at the input is associated with a specific pair of output rate and time difference values; the higher the output rate the further the local oscillator is driven from its intrinsic frequency.