Patents by Inventor Ehud Ben-Hur

Ehud Ben-Hur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of use of phthalocyanines to inactivate blood borne parasites
    Patent number: 5912241
    Abstract: This invention relates to a method for inactivating parasites in blood cell-containing compositions by incubating a mixture of the blood cell-containing composition, a phthalocyanine dye and a quencher and optionally irradiating this mixture with red light. This invention further relates to a method of sterilizing blood cell-containing compositions which contain lipid enveloped viruses and blood borne parasites.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: June 15, 1999
    Assignee: New York Blood Center, Inc.
    Inventors: Paul Gottlieb, Ehud Ben-Hur, Sara Lustigman
  • Method for treating viral infections
    Patent number: 5895786
    Abstract: The present invention provides a method for treating a viral infection in a subject. The method comprises administering to the subject an amount of 5-aminolevulinic acid and an iron-chelating agent to cause virus-infected cells to accumulate protoporphyrin in amounts such that upon application of a sufficient dose of red light, the virus-infected, protoporphyrin-accumulated cells will be destroyed; and applying a sufficient dose of red light to the virus-infected, protoporphyrin-accumulated cells to destroy the virus-infected, protoporphyrin-accumulated cells.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: April 20, 1999
    Assignee: New York Blood Center, Inc.
    Inventors: Ehud Ben-Hur, Zvi Malik
  • Red blood cell composition containing vitamin E or derivatives thereof which exhibits reduced potassium ion leakage after a photoinactivation process
    Patent number: 5858643
    Abstract: A red blood cell containing composition is presented which has reduced potassium ion leakage after irradiation in a virus photoinactivation process. The irradiated red blood cell containing composition comprises red blood cells, a photosensitizer, and sufficient vitamin E or derivatives thereof to prevent potassium leakage. Preferred photosensitizers are aluminum phthalocyanines, AlPcS.sub.4 or Pc5. A preferred vitamin E derivative is Trolox.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: January 12, 1999
    Assignee: New York Blood Center, Inc.
    Inventors: Ehud Ben-Hur, Shanti Rywkin, Bernard Horowitz
  • Process for the sterilization of biological compositions using UVA1 irradiation
    Patent number: 5789150
    Abstract: An improvement in a process for inactivating extracellular and intracellular viruses in a platelet containing composition is presented. The improvement in the process comprises adding a sensitizer to the platelet containing composition and irradiating the composition containing the sensitizer with UVA1 in the absence of UVA2 for a period of time sufficient to inactivate the viruses while retaining the functionality of the platelet containing composition. A quencher or mixture of quenchers of type I and type II photodynamic reactions may be advantageously added to the composition prior to irradiation.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: August 4, 1998
    Assignee: New York Blood Center, Inc.
    Inventors: Henrietta Margolis-Nunno, Ehud Ben-Hur, Bernard Horowitz
  • Process for the sterilization of biological compositions using UVA1 irradiation
    Patent number: 5658722
    Abstract: An improvement in a process for inactivating extracellular and intracellular viruses in a platelet containing composition is presented. The improvement in the process comprises adding a sensitizer to the platelet containing composition and irradiating the composition containing the sensitizer with UVA1 in the absence of UVA2 for a period of time sufficient to inactivate the viruses while retaining the functionality of the platelet containing composition. A quencher or mixture of quenchers of type I and type II photodynamic reactions may be advantageously added to the composition prior to irradiation.
    Type: Grant
    Filed: November 25, 1994
    Date of Patent: August 19, 1997
    Assignee: New York Blood Center, Inc.
    Inventors: Henrietta Margolis-Nunno, Ehud Ben-Hur, Bernard Horowitz
  • Photodynamic treatment of red blood cells with phthalocyanines and red light at higher light fluence rates is protective of red blood cells
    Patent number: 5637451
    Abstract: An improved process for inactivating an extracellular lipid enveloped virus or an intracellular lipid enveloped virus which may be present in an extracorporeal composition containing red blood cells by subjecting the composition to a virucidally effective amount of a phthalocyanine compound and red light of a fluence rate of at least above about 5 mW/cm.sup.2. Quite contrary to what would have been expected, it has been found that higher light fluence rates are, in fact, more protective of red blood cells than are lower light fluence rates.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: June 10, 1997
    Assignee: New York Blood Center, Inc.
    Inventors: Ehud Ben-Hur, Bernard Horowitz